6,544 research outputs found

    Out-of-control microglia cause cognitive deficits through excessive synaptic elimination in Alzheimer's disease

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    Doctoral dissertation submitted to obtain the degrees of:-Doctor of Biomedical Sciences | tUL-Doctor | Maastricht University Ben Rombaut Stichting transnationale Universiteit Limburg (tUL) is a cooperation between Hasselt University (Belgium) and Maastricht University (the Netherlands) and can be considered as one university with a home base in each country

    Out-of-control microglia cause cognitive deficits through excessive synaptic elimination in Alzheimer's disease

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    Doctoral dissertation submitted to obtain the degrees of:-Doctor of Biomedical Sciences | tUL-Doctor | Maastricht University Ben Rombaut Stichting transnationale Universiteit Limburg (tUL) is a cooperation between Hasselt University (Belgium) and Maastricht University (the Netherlands) and can be considered as one university with a home base in each country

    Weisheit von Sirach

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    "Ben Sira, wisdom of (also called Ecclesiasticus), a work of the Apocrypha, which, though usually known by this name, may have been called by its author, "The Words of Simeon b. Jeshua," the title found on the Hebrew fragments" (Encyc. Judaica, CD-Rom Ed., 1997)Erscheinungsjahr nach Vorlage: 279 [i.e. 1519]Ben Sira folgen noch eine Reihe anderer Abhandlungen cf. Steinschneider p. 203 No. 1363. Die wichtigsten NZ!Siehe auch Karl Heinz Burmeister, Sebastian Münster, in: Basler Beiträge zur Geschichtswissenschaft, Bd. 91, 1963, S. 8

    Autoworker and acclaimed author Ben Hamper speaks at the Michigan Writers Series

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    In an appearance at the Michigan State University Main Library, autoworker and acclaimed author Ben Hamper talks about his career at the General Motors Truck and Bus Plant in Flint, Michigan and reads from various works, including his forward to the book "Working words: punching the clock and kicking out the jams" by M. L. Liebler and from his most famous work, "Rivethead", a cynical and humorous view of life in an auto plant. A question and answer session follows. Hamper is introduced by Michigan State University Professor John P. Beck for the Michigan State University Libraries' Michigan Writers Series

    Martin Loughlin, Public Law and Political Theory

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    In this chapter, Ben Yong discusses Martin Loughlin’s Public Law and Political Theory. Drawing in part on conversation with the author, Yong explores the significance of a book that, despite interrogating the nature of public law as a discipline in a novel and methodologically important way, is often poorly understood

    Idan Ben-Barak: Cook Prize 2024, Silver Medal Acceptance Speech.

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    Author Idan Ben-Barak gives an acceptance speech for We Go Way Back (Roaring Brook Press)https://educate.bankstreet.edu/cook/1010/thumbnail.jp

    Book review: Contemporary Scottish plays, edited by Trish Reid

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    Book review: Contemporary Scottish plays, edited by Trish Reid. London: Bloomsbury, 2014; ISBN: 9781472574435 (£17.99)Publisher PD

    Exogenous Oxytocin Administration Restores Memory in Female APP/PS1 Mice

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    BACKGROUND: Current treatment options for Alzheimer's disease (AD) are limited, inefficient, and often have serious side effects. Oxytocin is a neuropeptide implicated in a variety of central processes, such as social and reproductive behaviors. Among others, it has garnered attention in various domains of psychiatric research, while its role in the development and course of neurodegenerative disorders like AD is rather unknown. OBJECTIVE: This study aimed to investigate the role of exogenous oxytocin administration on memory, specifically in view of AD, as a potential novel treatment option. METHODS: We describe a novel treatment approach by using a relatively low dose of long-term intranasal oxytocin treatment, to restore memory deficits in female APPswePS1dE9 mice. RESULTS: Female APPswePS1dE9 mice treated with oxytocin showed increased spatial memory performance in the object location task and improved working memory in the Y-Maze, while indicating decreased sociability. CONCLUSIONS: These results indicate that oxytocin is able to reverse acquired cognitive deficits in female APPswePS1dE9 mice

    Ben-Hur

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    Ben-Hur

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