1,721,116 research outputs found
A comparison of fatigue strength sensitivity to defects for materials manufactured by AM or traditional processes
Full text linkThe fatigue behavior of metallic materials fabricated via additive manufacturing processes is currently not well understood and it has been the subject of many experimental investigations in recent years. In this paper we carried out a literature review about the fatigue strength of additively manufactured AlSi10Mg and Ti6Al4V, especially in terms of sensitivity to defects and inhomogeneities. The analysis shows that fatigue properties and key variables (heat treatment, defect size) are very similar to the ones of parts obtained with traditional manufacturing processes. These results confirm that defect tolerant design concepts can be adopted also for AM components
Fiscal policy in Europe: the importance of being predictable
No full textThis paper provides evidence in support of the hypothesis that fiscal policy is
largely anticipated and its effects depend on the extent to which policy is able to
affect expectations. Based on a set of 2-country Bayesian VAR models between
major European economies, we nd that a surprise stimulus triggers expectations
of deficit reversals that may crowd out private expenditure. An anticipated stimulus, on the contrary, is found to boost domestic activity in all samples. Moreover,
it has positive cross-border effects in 50 percent of the cases. Overall, our findings
suggest that fiscal policy is effective when it is not crowded out by expectations
of reversals. We document such crowding out effects in Italy and France. Finally,
we argue that predictability has important consequences for the design of discretionary policy
Prevalence of hypertension: importance of epidemiologic studies and the need to spot undiagnosed cases
Full text linkThe actual prevalence and incidence of hypertension could have been higher and even more impactful on public health. Nonetheless, the work by Cegłowska et al. remains an important epidemiologic study, carefully conducted on nation wide scale. It demonstrates how arterial hypertension is extremely widespread, and highlights the need to improve blood pressure monitoring within a collaborative framework involving patients, general practitioners, and hypertension specialists, aimed at reducing the number of undiagnosed cases and improving patient management and public health. Moreover, since hypertension is becoming more prevalent in the elderly, efforts should be made to tailor health care to particular age groups
Foresight and the macroeconomic impact of fiscal policy: evidence for France, Germany and Italy
No full text
Measuring longitudinal left ventricular function and strain using cardiovascular magnetic resonance imaging
No full textnon
From Cell Phenotype to Epigenetic Mechanisms: New Insights Into Regenerating Myocardium
No full textThe self-regenerating property of the adult myocardium is not a new discovery. Even though we could not confirm that the adult myocardium is a post-mitotic tissue, we should consider that its plasticity is extremely low. Studies are still in progress to decipher the mechanisms underlying the abovementioned potential fetal features of the adult heart. The modest results of several clinical trials based on the transplantation of millions of autologous stem cells into the dysfunctional heart have confirmed that the cross-talk of different signals, such as the microenvironment, promotes the regeneration of adult myocardium. Recent scientific evidence has revealed that cellular cross-talk does not depend on the action of a single cell phenotype. It is conceivable that the limited turnover of cardiomyocytes is ensured by the interplay of adult cardiac cells in response to environmental changes. The epigenetic state of a cell serves as a dynamic interface between the environment and phenotype. The epigenetic modulation of the adult cardiac cells by natural active compounds encourages further studies to improve myocardial plasticity. In this review, we will highlight the most relevant studies demonstrating the epigenetic modulation of myocardial regeneration without the use of stem cell transplantation
Reversal of right-ventricular dysfunction in pulmonary arterial hypertension following sildenafil therapy
No full textN/
- …
