1,721,033 research outputs found
Domino reaction sequences under rhodium catalyzed hydroformylation of 3-acetyl-1- allylpyrrole: a shortcut way to 5,6,7,8-tetrahydroindolizines
No full textA novel case of 1,3-asymmetric induction in rhodium-catalyzed hydroformylation of an allylic double bond using perbenzylated C-glucosides as chiral directors,
No full text1-(20,30,40,60-Tetra-O-benzyl-a-D-glucopyranosyl)-2-propene 1a and 1-(20,30,40,60-tetra-O-benzyl-b-D-glucopyranosyl)-2-
propene 1b were hydroformylated at different temperatures affording linear and branched aldehydes in either a 1:1 or 2:1 regioisomeric
ratio, depending on the stereochemistryof the starting substrate. The diastereoisomeric ratio of the branched isomer depended
on the reaction temperature as well as the alkene structure, the highest value (85:15) being obtained in the case of hydroformylation
of the a-isomer at 0 °C
Vascular smooth muscle cell activation: proteomics point of view
No full textVascular smooth-muscle cells (VSMCs) are the main component of the artery medial layer. Thanks to their great plasticity, when stimulated by external inputs, VSMCs react by changing morphology and functions and activating new signaling pathways while switching others off. In this way, they are able to increase the cell proliferation, migration, and synthetic capacity significantly in response to vascular injury assuming a more dedifferentiated state. In different states of differentiation, VSMCs are characterized by various repertories of activated pathways and differentially expressed proteins. In this context, great interest is addressed to proteomics technology, in particular to differential proteomics. In recent years, many authors have investigated proteomics in order to identify the molecular factors putatively involved in VSMC phenotypic modulation, focusing on metabolic networks linking the differentially expressed proteins. Some of the identified proteins may be markers of pathology and become useful tools of diagnosis. These proteins could also represent appropriately validated targets and be useful either for prevention, if related to early events of atherosclerosis, or for treatment, if specific of the acute, mid, and late phases of the pathology. RNA-dependent gene silencing, obtained against the putative targets with high selective and specific molecular tools, might be able to reverse a pathological drift and be suitable candidates for innovative therapeutic approaches
Substrate-directed asymmetric induction in the rhodium catalyzed hydroformylation of C-allyl-sugars: The influence of the glycoside-moiety on the selectivity of the reaction
No full textand C-allylgalactopyranosides 1c and 1d, -C-allylazaglucopyranoside 1e and -C-allylfruttofuranoside 1f were hydroformylated at low temperatures affording a mixture of linear and branched aldehydes in regioisomeric and diastereoisomeric ratios depending on the starting alkene. The results obtained have allowed us to study the influence of the different structural features of the sugar moiety on the regio- and diastereoselectivity of the hydroformylation reaction
Proteomica e medicina personalizzata
No full textWith the disclosure of the human genome a new
era for bio-medicine has arisen, characterized by the challenge
to investigate pathogenic mechanisms, studying simultaneously
metabolites, DNA, RNA, and proteins. As a result,
the “omics” revolution boomed, giving birth to a new
medicine named “omics-based medicine”. Among the other
“omics”, proteomics has been widely used in medicine,
since it can produce a more “holistic” overview of a disease
and provide a “constellation” of possible specific markers, a
molecular fingerprinting that defines the clinical condition
of an individual. Endpoint of this comprehensive and detailed
analysis is the diagnostic-“omics”, i.e. the achievement
of personalized diagnoses with obvious benefits for prevention
and therapy and this goal can be reached only with
a perfect integration between clinicians and proteomists.
To impact on the possible key factors involved in the pathological
processes, oligonucleotide-based knock-down
strategies can be helpful. They exploit omics-derived molecular
tools (antisense, siRNA, ribozymes, decoys, and aptamers)
that can be used to inhibit, at the transcriptional or
post-transcriptional levels, the events leading to protein
synthesis, thus decreasing its expression. The identification
of the pivotal mechanisms involved in diseases using global,
“scenic” approaches such as the “omics” ones, and the
subsequent validation and detailed description of the
processes by specific molecular tools, can result in a more
preventive, predictive and personalized medicine
Evidence for formation and different evolution of tertiary rhodium alkyl intermediates under rhodium-catalyzed deuterio-(hydro)formylation of 1-(n-pyridyl)-1-phenylethenes
No full textChiral N-Allylpyrroles as Versatile Substrates Under Rhodium-Catalyzed Hydroformylation: Good Regio- and Diastereo-Selectivity at Room Temperature and High Pressure
No full textThe chiral (S)-3-alkyl-3-(pyrrol-1-yl)prop-1-enes (1a-c) were hydroformylated at 20 °C and high pressure (100 atm) giving the branched aldehydes 2-methyl-3-(pyrrol-1-yl)alkanales (2+2’) with a good region-selectivity and a high diastereomeric excess (2/2’ up to 90:10). The absolute configuration of the diastereomers was assigned via NMR measurements, 2S,3S being the predominant one
From chiral and prochiral N-allylpyrroles to stereodefined pyrrole fused architectures: a specific application of the rhodium catalyzed hydroformylation
No full textComplete 1,3-asymmetric induction into 3-methyl-(3-acetylpyrrol-1-yl)butanal to 1-acetyl-6- methyl-8-hydroxy-5,6,7,8-tetrahydroindolizine cyclization
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