1 research outputs found
Jumlah Kelenjar Limfe sebagai Prediktor Kesintasan Penderita Kanker Serviks yang Dilakukan Histerektomi Radikal dan Limfadenektomi
No full textKanker serviks merupakan kanker keempat tersering pada perempuan di dunia.Di Indonesia pada tahun2013 terdapat 838 kasus kanker serviks dan pada tahun 2014 meningkat menjadi 1632 kasus. Berdasarkanprognosis dan terapi, kanker serviks dibagi dua kelompok yaitu stadium awal (IA-IIA) dan stadium lanjut (IIBIVB).Tatalaksana kanker serviks stadium awal adalah pembedahan atau radioterapi. Pembedahan berupahisterektomi radikal dan limfadenektomi. Pada penderita kanker serviks stadium awal yang berusia muda,umumnya dilakukan histerektomi radikal karena ovarium dan vagina ingin dipertahankan. Histerektomi radikaldan limfadenektomi lebih disukai dibandingkan radioterapi karena pada radioterapi dapat terjadi kerusakanpermanen jaringan normal di lokasi neoplasma. Keterlibatan kelenjar limfe merupakan salah satu faktoryang memengaruhi kesintasan penderita kanker serviks. Angka kesintasan 5 tahun penderita kanker serviksmenurun 25-60% apabila terdapat metastasis ke kelenjar limfe. Berdasarkan status nodul, angka 5 tahundisease-free survival 80,9-83,3% pada pasien dengan nodul positif dan 90,2-97,8% pada nodul negatif.Kesintasan kanker serviks masih rendah, sehingga diperlukan prediktor agar dapat dilakukan tindakan lebihlanjut untuk meningkatkan kesintasan. Jumlah pengangkatan nodul limfe dapat meningkatkan kesintasan,namun belum diketahui hubungan jumlah pengangkatan nodul limfe dengan kesintasan pasien kankerserviks stadium awal. Perlu dilakukan penelitian untuk mengetahui jumlah kelenjar limfe yang diekstraksisebagai prediktor kesintasan pasien kanker serviks yang dilakukan histerektomi radikal dan limfadenektomi. Kata kunci: prediktor kesintasan, kanker serviks, histerektomi, limfadenektomi, jumlah kelenjar limfe Number of Lymph Nodes Extraction as Predictor of Cervical CancerPatient’s Survival who did Radical Hysterectomy and Lymphadenectomy Abstract Cervical cancer is the fourth most common cancer in women in the world. In Indonesia, there were 838 cases of cervical cancer in 2013 and increased to 1632 cases in 2014. Based on the prognosis and treatment, cervicalcancer is divided into two groups: early stage (IA-IIA) and advanced stages (IIB-IVB). The treatment of earlystage cervical cancer is surgery or radiotherapy. Surgery means a radical hysterectomy and lymphadenectomy.In young patients with early stage, generally performed radical hysterectomy because ovaries and vagina need tobe maintained. Radical hysterectomy and lymphadenectomy is preferable to radiotherapy because radiotherapycan permanently damage normal tissue at the site of the neoplasm. Lymph node involvement is one of thefactors that affect the survival of cervical cancer. 5-year survival rate of cervical cancer decreased by 25-60% ifthere is metastasis to the lymph nodes. Based on the status of nodules, number 5-year disease-free survival of80.9-83.3% in patients with positive nodes and 90.2-97.8% in negative nodules. Cervical cancer survival rate is still low, therefore its necessary to have a predictor of survival in order to do further action to improve survival. The amount of removal of the lymph nodes may improve survival, but the relationship between the number oflymph nodes removal and survival for early stage of cervical cancer patients is unknown. Research is neededto determine the number of lymph nodes were extracted as a predictor of patient’s survival with cervical cancerwho performed a radical hysterectomy and lymphadenectomy. Keywords: survival predictor, cervical cancer, hysterectomy, lymphadenectomy, lymph nodes numbe
