7 research outputs found
Extraordinary and prolonged Erlotinib-induced clinical response in a patient with EGFR wild-type squamous lung cancer in third-line therapy: a case report
No full textSeveral small molecules, epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs), such as gefitinib, erlotinib and afatinib, have been demonstrated to significantly improve clinical outcomes in patients with advanced EGFR-mutated non-small cell lung cancer (NSCLC), but erlotinib activity in EGFR wild-type squamous carcinoma is still highly debated. Here, we describe a prolonged and unexpected clinical response to erlotinib in a male former heavy cigarette smoker with wild-type EGFR squamous-cell cancer
Extraordinary and prolonged Erlotinib-induced clinical response in a patient with EGFR wild-type squamous lung cancer in third-line therapy: a case report
No full textElisabetta Gambale,1 Consiglia Carella,1 Paolo Amerio,2 Fiamma Buttitta,3 Rosa Lucia Patea,4 Clara Natoli,1 Michele De Tursi1 1Medical Oncology Unit, Department of Medical, Oral and Biotechnological Sciences, 2Department of Dermatology and Venereology, University G. d’Annunzio, Chieti, 3Department of Medicine and Aging Sciences, University of Chieti-Pescara, Chieti, 4Department of Radiologic Sciences, University of Chieti-Pescara, Chieti, Italy Abstract: Several small molecules, epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs), such as gefitinib, erlotinib and afatinib, have been demonstrated to significantly improve clinical outcomes in patients with advanced EGFR-mutated non-small cell lung cancer (NSCLC), but erlotinib activity in EGFR wild-type squamous carcinoma is still highly debated. Here, we describe a prolonged and unexpected clinical response to erlotinib in a male former heavy cigarette smoker with wild-type EGFR squamous-cell cancer. Keywords: erlotinib, squamous NSCLC, EGFR wild typ
The boundaries of education: using mobile devices for connecting people to places
No full textThis discussion paper explores pedagogy beyond the boundaries of tertiary institutional classrooms through a sociocultural lens that examines the history of a small-town community.In doing so, this paper discusses the principles informing the study and exploratory stages, and is not intended as an empirical research paper. Rather it outlines the use of mobile technologies to enhance the documentation of the sociocultural story of a community and as such presents a potentially transferable framework for utilising mobile mixed reality (MMR) to create authentic informal learning environments.This paper utilises (mobile) mixed media to document the historical, industrial and community growth and demise of a small town called Patea in Taranaki, New Zealand. Using practice-led methodology through a heuristic inquiry approach, the aim of the study is to demonstrate how MMR technology can be used to document the historical events and workers’ narratives of the town and then be gifted back to the town as artistic educational material for future generations.As an example of a ‘new genre of public art’, this paper reflects on the collection of multiple forms of media capturing recorded interviews and the communication of the spoken word, mobile phone filming, drone footage, 360-degree photography/film, site recordings and the memories of what a place could be to create a new form of educational augmented reality/virtual reality (AR/VR) audio visual portraiture. The author argues that the use of MMR to form a collection of AR/VR short film poems creates powerful portraits of the people who worked in the now abandoned cool stores and freezing works at Patea
Structured reporting for fibrosing lung disease: a model shared by radiologist and pulmonologist
No full textTo apply the Delphi exercise with iterative involvement of radiologists and pulmonologists with the aim of defining a structured reporting template for high-resolution computed tomography (HRCT) of patients with fibrosing lung disease (FLD)
La ficción histórica de Alfredo Iriarte: una reacción frente a la mitificación de lo latinoamericano
No full textAlfredo Iriarte was a Bogotan writer that published most of his work on the late 20th century. Despite his fictional works cover three different genres (chronicles, short stories and novel) and he has been published by different publishing houses in and out Colombia, he is somewhat a public secret within the Colombian literary field. Due to this, the present research constitutes a first critical approach to his fictional work. This is developed from an aesthetic evaluation of the three genres mentioned, their procedures, resources and most relevant ideas within the works. At the same time, this research develops a socio-historical interpretation of the literary works, which puts in perspective the context faced by the author and the position he assumed and standed for in regard of the problems of his interest. This allows us to understand the "historical fiction" of Alfredo Iriarte as a reaction to the official historical discourse in Colombia and to the mythification of history in the broad context of Latin America.Alfredo Iriarte fue un escritor bogotano que publicó la mayoría de sus obras a finales del siglo XX. A pesar de que su obra ficcional cubre tres géneros distintos (crónica, relato breve y novela) y ha sido publicado por diferentes editoriales dentro y fuera de Colombia, es una especie de secreto a voces dentro del campo literario colombiano. Debido a ello, la presente investigación constituye una primera aproximación crítica a su obra ficcional. Esta se desarrolla a partir de una evaluación estética de los tres géneros mencionados, de sus procedimientos, recursos e ideas más relevantes dentro de las obras. A su vez, esta investigación propone una interpretación sociohistórica de las obras que pone en perspectiva la realidad a la que se enfrentó el autor y la posición que asumió y defendió frente a las problemáticas de su interés. Esto permite entender la ficción histórica de Alfredo Iriarte como una reacción frente al discurso histórico oficial en Colombia y frente a la mitificación de la historia en el amplio contexto de lo latinoamericano.Línea de Investigación: Escuela de Estéticas sociológicasMaestrí
