1,720,976 research outputs found
Duodenal stenosis may not regress after eradication of Helicobacter pylori
No full textIt has been reported recently (1-3) that duodenal stenosis, a complication of ulcer disease, disappears after Helicobacter pylori eradication. However, in this report we describe a patient with recurrent duodenal ulcer in whom duodenal stenosis developed that did not disappear after eradication of H. pylori
Lansoprazole/amoxicillin versus omeprazole/amoxicillin in Helicobacter pylori eradication
No full textOmeprazole plus clarithromycin and either tinidazole or tetracycline for Helicobacter pylori treatment
No full text
The management of failed dual or triple therapy for Helicobacter pylori eradication
No full textAbstract: Background: After each treatment for Helicobacter pylori infection there is an eradication failure rate ranging from 5 to 50%, Thus, the best therapy schedule and treatment regimen sequence have still to be identified. Methods: Patients with H. pylori infection were randomized to receive either a 1-week triple therapy of omeprazole 20 mg b.d., clarithromycin 250 mg b.d. and tetracycline 500 mg b.d. (OCT; 78 patients) or a 2-week dual therapy of omeprazole 20 mg b.d. and amoxycillin 1 g b.d. (OA; 75 patients), H. pylori infection at entry and eradication 4-6 weeks after therapy had ended were assessed by rapid urease test and histology on biopsies from the antrum and the corpus, When eradication did not occur with either the OCT or OA regimens, patients were switched over to the OA or OCT therapy, respectively. Eradication in these patients was assessed 4-6 weeks after conclusion of treatment by a further endoscopy. Results: H. pylori eradication was achieved in 67.9% (95% CI = 57.6-78.3%) of patients treated with the OCT regimen and in 75.7% (95% CI = 65.9-85.5%) of patients treated with the OA therapy (chi(2) = 1.11; P = 0.29), Moreover, H. pylori eradication was achieved in 39.1% (95% CI = 19.2-59.1%) of patients re-treated with the OA regimen and in 88.9% (95% CI = 74.4-100%) of patients re-treated with the OCT therapy (chi(2) = 8.52; P = 0.003). Thus, the overall success rate 'per protocol' analysis in our study was 81.6% (95% CI = 72.9-90.3%) for the triple and dual therapy sequence and 97.3% (95% CI = 93.6-100%) for dual followed by triple therapy (chi(2) = 8.14; P = 0.004). Conclusions: Our data found that H. pylori eradication with OA therapy after OCT therapy failure was poor, while that obtained with OCT after OA therapy was good
Omeprazole plus clarithromycin and either tinidazole or tetracycline for Helicobacter pylori infection: A randomized prospective study
No full textObjective: Helicobacter pylori has begun to show resistance to imidazoles and could result in the low efficacy of short-term triple therapy, The aim of this study was to assess whether administration of tetracycline instead of tinidazole in short-term low-dose triple therapy could increase the H. pylori eradication rate, Methods: In a prospective study, 113 patients with peptic ulcer (n = 36) or non-ulcer dyspepsia (n = 77) were randomized to receive 1-wk treatment, composed of omeprazole 20 mg b.i.d., clarithromycin 250 mg b.i.d., and either tinidazole 500 mg b.i.d. (n = 57) or tetracycline 500 mg b.i.d. (n = 56), upon detection of H. pylori infection at endoscopy, Results: H. pylori eradication, defined as a negative bacterial finding in a rapid urease test and upon histologic assessment at least 4 wk after cessation of therapy, was achieved in 86% (49 of 57; 95% confidence interval = 76.9 - 95) of patients in the first group and in 71.4%, (40 of 56; 95% confidence interval = 59.6 - 83.3) in the second group (p = not significant), Side effects occurred in 28% of patients from the tinidazole-based group and in 12.5% from the tetracycline group (p = not significant), Two patients in the tinidazole group discontinued therapy at 5 and 6 days because of side effects, Conclusions: The administration of tetracycline instead of tinidazole in short-term triple therapy yielded disappointing results in H. pylori eradication
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