1,673 research outputs found
Combined analysis of CSF betaA42 peptide and tau protein and serum antibodies to glycosaminoglycans in Alzheimer's disease: preliminary data.
No full textBasilar arterio-venous pseudoparallelism due to persistence of embryonal venous pattern.
No full textA vascular malformation, consisting of a venous vessel bridgeing the right inferior petrosal sinus and the anterior spinal veins, was found in the posterior fossa. The vessel presented a ring-like course around the right trigeminal root, and it was parallel and dorsal to the basilar artery. The malformation was associated with cutaneous and hepatic angiomas and peri-osteal lipomas. It had been clinically silent for 52 years, when it thrombosed causing death. The authors think that, within a general mesenchymopatic state, this is a result of the persistence of an embryonal cerebral venous pattern
Combined analysis of CSF ßA42 peptide and tau protein and serum antibodies to glycosaminoglycans in Alzheimer's Disease: preliminary data
No full textNeuropathological hallmarks of Alzheimer's disease (AD) are amyloid plaques and neurofibrillary tangles, containing betaA(42) peptide and tau protein, respectively. Amyloid plaques contain also glycosaminoglycans (GAGs). Whereas cerebrospinal fluid (CSF) levels of betaA(42) peptide and tau protein have been demonstrated as potential markers of Alzheimer's disease (AD), no data are available for GAGs. We determined (Elisa) tau and betaA(42) CSF levels, as well as serum antibodies to GAGs in 9 AD patients, and the values were analyzed in relation to age and severity of the disease. Beta-A42 and tau CSF levels were significantly reduced and increased, respectively, in AD patients when compared to controls, but they did not correlate with the severity of the disease. Despite their role in amyloidogenesis, we did not find evidence for the use of GAGs as diagnostic marker of AD
15.11. Positron emission tomography (PET) study of the acute functional cerebral effects of L-alfa-glyceryl-phosphoryl-ethanolamine (GPE) in mild Alzheimer’s disease patients.
No full textPositron emission tomography (PET) study of the acute cerebral effects of L-alpha-glyceryl-phosphoryl-ethanolamine in mild Alzheimer's disease patients.
No full textAnti-heparan sulfate antibodies: Possible marker for vascular dementia?
No full textThe availability of specific biologic markers may greatly improve early diagnosis of dementia. Whereas CSF tau and beta42 peptide levels are sensitive markers of Alzheimer's Disease (AD), no reliable biochemical tests are so far available for Vascular Dementia (VD). Increasing evidence supports a pathogenic role of Heparan Sulfate (HS) in the development of dementia. Using an innovative ELISA, we tested sera from patients with AD and other neurological diseases, for the presence of antibodies (Abs) to HS. We did not find increased titres of anti-HS Abs in AD patients. Interestingly, however, high titres were present in subjects with vascular damage, due to cerebral vasculitis/vasculopathy. Because HS proteoglycans arc present in the endothelial cells and perivascular basement membrane, these findings rise the possibility of assessing these Abs as possible markers of VD, in which the combined analysis of CSF tau and beta42 peptide yields the lowest specificity. Only a prospective study on a large cohort of patients with cognitive impairment of different ethiology will clarify whether anti-HS Abs could be diagnostic or predictive markers of VD
Globalization of Distinguished Supercuspidal Representations of GL(n)
No full textAn irreducible supercuspidal representation of = GL(n, ), where is a nonarchimedean local field of characteristic zero, is said to be “distinguished” by a subgroup of and a quasicharacter of if Hom(, ) ≠ 0. There is a suitable global analogue of this notion for an irreducible, automorphic, cuspidal representation associated to GL(n). Under certain general hypotheses, it is shown in this paper that every distinguished, irreducible, supercuspidal representation may be realized as a local component of a distinguished, irreducible automorphic, cuspidal representation. Applications to the theory of distinguished supercuspidal representations are provided
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