1,721,145 research outputs found
Innovation in Pain Management
No full textThe transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, on 12 December 2002.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2004.©The Trustee of the Wellcome Trust, London, 2004.All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/.Annotated and edited transcript of a Witness Seminar held on 12 December 2002. Introduction by Dr Christina Faull; edited interview with Professor Patrick Wall.Annotated and edited transcript of a Witness Seminar held on 12 December 2002. Introduction by Dr Christina Faull; edited interview with Professor Patrick Wall.Annotated and edited transcript of a Witness Seminar held on 12 December 2002. Introduction by Dr Christina Faull; edited interview with Professor Patrick Wall.Annotated and edited transcript of a Witness Seminar held on 12 December 2002. Introduction by Dr Christina Faull; edited interview with Professor Patrick Wall.Annotated and edited transcript of a Witness Seminar held on 12 December 2002. Introduction by Dr Christina Faull; edited interview with Professor Patrick Wall.Annotated and edited transcript of a Witness Seminar held on 12 December 2002. Introduction by Dr Christina Faull; edited interview with Professor Patrick Wall.Unrelieved pain caused by cancer is experienced by more than 5 million people worldwide, and over the past 50 years has been accepted as unnecessary by both clinicians and politicians. Major innovations in the understanding of pain and our ability to treat it have been made. This Witness Seminar, chaired by Professor David Clark, describes the development of pain clinics, the introduction of the hospice in Britain, and global implementation of innovative technologies for cancer pain relief and advances in research during the latter part of the twentieth century. International health planners argue that the outstanding challenge is to put this knowledge into practice in healthcare settings around the world, often where resources are limited. Reynolds L A, Tansey E M. (eds) (2004) Innovation in pain management, Wellcome Witnesses to Twentieth Century Medicine, vol. 21. London: The Wellcome Trust Centre for the History of Medicine at UCL.The Wellcome Trust Centre for the History of Medicine at University College London is funded by the Wellcome Trust,which is a registered charity, no. 210183
Early Heart Transplant Surgery in the UK
No full textAnnotated and edited transcript of a Witness Seminar held on 10 June 1997. Introduction by E M Tansey.First published by the Wellcome Trust, 1999.©The Trustee of the Wellcome Trust, London, 1999 updated 2005 in new pdf, revised ISBN, 2010.All volumes are freely available online following the links to Publications/Wellcome Witnesses at
www.ucl.ac.uk/histmedAnnotated and edited transcript of a Witness Seminar held on 10 June 1997. Introduction by E M Tansey.Annotated and edited transcript of a Witness Seminar held on 10 June 1997. Introduction by E M Tansey.Annotated and edited transcript of a Witness Seminar held on 10 June 1997. Introduction by E M Tansey.Annotated and edited transcript of a Witness Seminar held on 10 June 1997. Introduction by E M Tansey.Some of the key players in the early heart transplant operations in the UK gathered to consider the events of 1968, when the first transplants took place and their immediate and long-term implications. Not only were surgical advances reviewed, but also the professional, social and legal disquiet at what, by the end of the 20thC, has become a widely accepted and almost routine operation for many cardiovascular surgeons. Cardiac surgeons attending include: Professor Tom Treasure (Chair), Sir Terence English, Professor Donald Longmore, Mr Barry Ross, Mr Donald Ross, Sir Keith Ross, and Mr John Wallwork. Several distinguished cardiologists and anaesthetists also contributed. Tansey E M, Reynolds L A. (eds) (1999) Early heart transplant surgery in the UK, Wellcome Witnesses to Twentieth Century Medicine, vol. 3. London: The Wellcome Trust.Tansey E M, Reynolds L A. (eds) (1999) Early heart transplant surgery in the UK, Wellcome Witnesses to Twentieth Century Medicine, vol. 3. London: The Wellcome Trust.The Wellcome Trust is a registered charity, no. 210183
Cholesterol, Atherosclerosis and Coronary Disease in the UK, 1950–2000.
No full textAnnotated and edited transcript of a Witness Seminar held on 8 March 2005. Introduction by Dr Nick Myant, Hammersmith Hospital, London.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2006. ©The Trustee of the Wellcome Trust, London, 2006. All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edited transcript of a Witness Seminar held on 8 March 2005. Introduction by Dr Nick Myant, Hammersmith Hospital, London.Annotated and edited transcript of a Witness Seminar held on 8 March 2005. Introduction by Dr Nick Myant, Hammersmith Hospital, London.Annotated and edited transcript of a Witness Seminar held on 8 March 2005. Introduction by Dr Nick Myant, Hammersmith Hospital, London.Annotated and edited transcript of a Witness Seminar held on 8 March 2005. Introduction by Dr Nick Myant, Hammersmith Hospital, London.Annotated and edited transcript of a Witness Seminar held on 8 March 2005. Introduction by Dr Nick Myant, Hammersmith Hospital, London.Annotated and edited transcript of a Witness Seminar held on 8 March 2005. Introduction by Dr Nick Myant, Hammersmith Hospital, London.Cholesterol began to be accepted after the Second World War as a significant cause of atherosclerosis and associated conditions such as coronary heart disease (CHD). This Witness Seminar, chaired by Professor Michael Oliver, included a discussion of the basic research on cholesterol. Early epidemiological studies demonstrated the relationship between excess saturated fat consumption and elevated levels of cholesterol, although cholesterol alone did not explain all population differences. Work on lipoprotein metabolism pointed to hypercholesterolaemia as one of, if not the major, risk factors for CHD, culminating in the development of cholesterol-lowering drugs, particularly the successful statins, available in the UK from the 1980s, and confirmed by randomized controlled trials. The role of diet in heart disease had always been controversial in the UK, and although extreme diets could reduce cholesterol, patient conformity remains difficult. Later, recommended limits on the composition of dietary fat were agreed, assisted by the food industry's introduction of functional foods such as cholesterol-lowering margarine. An introduction by Dr Nick Myant and appendices, on the diet-heart hypothesis by Professor Gerry Shaper and the development of lovastatin by Dr Jonathan Tobert, compliment the transcript. Contributors include Professor David Barker, Professor John Betteridge, Professor Gustav Born, Professor Richard Bruckdorfer, Professor George Davey Smith, Professor Paul Durrington, Professor David Galton, Dr Arthur Hollman, Professor Steve Humphries Professor Gordon Lowe, Professor Vincent Marks, Dr Paul Miller, Professor Jerry Morris, Professor Chris Packard, Professor Stuart Pocock, Professor Kalevi Pyörälä, Professor Thomas Sanders, Professor James Scott, Dr Elspeth Smith, Professor Anne Soutar, Professor Gilbert Thompson, Professor Hugh Tunstall-Pedoe, Professor Neville Woolf and Professor John S Yudkin. Reynolds L A, Tansey E M. (eds) (2006) Cholesterol, atherosclerosis and coronary disease in the UK, 1950–2000, Wellcome Witnesses to Twentieth Century Medicine, vol. 27. London: The Wellcome Trust Centre for the History of Medicine at UCL.The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183
Clinical Pharmacology in the UK, c.1950-2000: Industry and Regulation
No full textAnnotated and edited transcript of a Witness Seminar held on 25 September 2007. Introduction by Professor Parveen Kumar, Barts and the London School of Medicine and Dentistry, University of London.First published by the Wellcome Trust Centre
for the History of Medicine at UCL, 2008. ©The Trustee of the Wellcome Trust, London, 2008.All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edited transcript of a Witness Seminar held on 25 September 2007. Introduction by Professor Parveen Kumar, Barts and the London School of Medicine and Dentistry, University of London.Annotated and edited transcript of a Witness Seminar held on 25 September 2007. Introduction by Professor Parveen Kumar, Barts and the London School of Medicine and Dentistry, University of London.Annotated and edited transcript of a Witness Seminar held on 25 September 2007. Introduction by Professor Parveen Kumar, Barts and the London School of Medicine and Dentistry, University of London.Annotated and edited transcript of a Witness Seminar held on 25 September 2007. Introduction by Professor Parveen Kumar, Barts and the London School of Medicine and Dentistry, University of London.Annotated and edited transcript of a Witness Seminar held on 25 September 2007. Introduction by Professor Parveen Kumar, Barts and the London School of Medicine and Dentistry, University of London.Annotated and edited transcript of a Witness Seminar held on 25 September 2007. Introduction by Professor Parveen Kumar, Barts and the London School of Medicine and Dentistry, University of London.Clinical pharmacology in the UK in the 1950s and 1960s was an exciting profession. Many important new drugs were developed and brought to market and a more systematic knowledge of drug effects in humans was needed, as well as ensuring the safety and efficacy of new and existing drugs, especially following the unexpected problems arising from the use of thalidomide. This Witness Seminar followed an earlier meeting on the history of the general development of clinical pharmacology and focuses on the development of clinical pharmacology in pharmaceutical companies and drug regulation. Professor Rod Flower chaired the meeting of clinical pharmacologists and others who shaped the discipline, which discussed the main centres of influence; the attraction to clinical pharmacologists of working in industry; whether the decline in the number of academic clinical pharmacologists was paralleled in drug companies; what drove drug regulation; and the relationships between companies and regulatory authorities. Participants included Dr Jeffrey Aronson, Professor Nigel Baber, Sir Alasdair Breckenridge, Sir Iain Chalmers, Professor Joe Collier, Professor Donald Davies, Dr Peter Fletcher, Dr Arthur Fowle, Professor Sir Charles George, Professor David Grahame-Smith, Professor John Griffin, Dr Andrew Herxheimer, Professor Ray Hill, Dr Peter Lewis, Dr Tim Mant, Professor Denis McDevitt, Professor Michael Orme, Dr Anthony Peck, Professor Brian Prichard, Professor Sir Michael Rawlins, Professor John Reid, Professor Philip Routledge, Dr Julian Shelley, Dr Robert Smith, Professor Cameron Swift, Professor Tilli Tansey, Dr Duncan Vere, and the late Professor Owen Wade. Reynolds L A, Tansey E M. (eds) (2008) Clinical pharmacology in the UK, c. 1950–2000: Industry and regulation. Wellcome Witnesses to Twentieth Century Medicine, vol. 34. London: The Wellcome Trust Centre for the History of Medicine at UCL.The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183
History of British Intensive Care, c. 1950–c. 2000
No full textAnnotated and edited transcript of a Witness Seminar held on 16 June 2010. Introduction by Professor Sir Ian Gilmore, Royal Liverpool Hospital and University of Liverpool.Annotated and edited transcript of a Witness Seminar held on 16 June 2010. Introduction by Professor Sir Ian Gilmore, Royal Liverpool Hospital and University of Liverpool.Annotated and edited transcript of a Witness Seminar held on 16 June 2010. Introduction by Professor Sir Ian Gilmore, Royal Liverpool Hospital and University of Liverpool.Annotated and edited transcript of a Witness Seminar held on 16 June 2010. Introduction by Professor Sir Ian Gilmore, Royal Liverpool Hospital and University of Liverpool.Annotated and edited transcript of a Witness Seminar held on 16 June 2010. Introduction by Professor Sir Ian Gilmore, Royal Liverpool Hospital and University of Liverpool.Annotated and edited transcript of a Witness Seminar held on 16 June 2010. Introduction by Professor Sir Ian Gilmore, Royal Liverpool Hospital and University of Liverpool.Annotated and edited transcript of a Witness Seminar held on 16 June 2010. Introduction by Professor Sir Ian Gilmore, Royal Liverpool Hospital and University of Liverpool.Annotated and edited transcript of a Witness Seminar held on 16 June 2010. Introduction by Professor Sir Ian Gilmore, Royal Liverpool Hospital and University of Liverpool.Intensive care developed in the UK as a medical specialty as the result of some extraordinary circumstances and the involvement of some extraordinary people. In 1952, the polio epidemic in Copenhagen demonstrated that tracheostomy with intermittent positive pressure ventilation saved lives and those infected with tetanus (common in agricultural areas) soon benefited. War-time developments such as triage, monitoring, transfusion and teamwork, and different specialists such as respiratory physiologists, anaesthetists and manufacturers of respiratory equipment all improved emergency treatment. These advances were rapidly extended to the care of post-operative patients, particularly with developments in cardiac surgery. Dedicated units appeared in the early 1960s in Cambridge, London and Liverpool, and later specialist care units were created for prenatal, cardiac and dialysis patients. The importance of specialist nursing care led to the development of nurse training, education and the eventual appointment of nurse consultants in the NHS in 1999. The specialty of intensive care was granted Faculty status by the GMC in 2010. Introduced by Professor Sir Ian Gilmore, this transcript includes, inter alia, the development of cardiac catheters, monitoring equipment, data collection techniques and the rise of multidisciplinarity, national audit, and scoring systems
Medical Ethics Education in Britain, 1963-1993
No full textAnnotated and edited transcript of a Witness Seminar held on 9 May 2006. Introduction by Professor Sir Kenneth Calman.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2007.©The Trustee of the Wellcome Trust, London, 2007.All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edited transcript of a Witness Seminar held on 9 May 2006. Introduction by Professor Sir Kenneth Calman.Annotated and edited transcript of a Witness Seminar held on 9 May 2006. Introduction by Professor Sir Kenneth Calman.Annotated and edited transcript of a Witness Seminar held on 9 May 2006. Introduction by Professor Sir Kenneth Calman.Annotated and edited transcript of a Witness Seminar held on 9 May 2006. Introduction by Professor Sir Kenneth Calman.Annotated and edited transcript of a Witness Seminar held on 9 May 2006. Introduction by Professor Sir Kenneth Calman.Annotated and edited transcript of a Witness Seminar held on 9 May 2006. Introduction by Professor Sir Kenneth Calman.Changing attitudes toward human experimentation along with other controversial moral issues emerged after the Second World War and, in 1963, led to the London Medical Group, organized by Ted Shotter, with similar Medical Groups emerging elsewhere from 1967. These became forums for discussion and debate arising from dilemmas encountered in medical settings. Medical ethics did not become a recognized subject in the syllabus of Britain's medical schools until 1993. This Witness Seminar transcript records the development of international ethical codes, the response to them over the period 1963-93 by students and doctors and the extent of resistance encountered from Deans, hospital administrators and others; the Groups' influence on medical practice; the impact on both Medical Group organizers and participants in their subsequent careers; the local and regional variations and their significant lasting contributions. The meeting was chaired by Dr Stephen Lock and included former Medical Group members, scientists, physicians and policy makers, such as Professors Kenneth Boyd, Bill Fulford, Roger Higgs, Bryan Jennett,, Sir Ian Kennedy, David Morton, and Sir Malcolm Macnaughton. An introduction by Professor Sir Kenneth Calman and appendices of the Very Revd Edward Shotter's reflections on the influence of the Medical Groups as a report for the Institute of Medical Ethics complete the transcript. Reynolds L A, Tansey E M. (eds) (2007) Medical ethics education in Britain, 1963–93, Wellcome Witnesses to Twentieth Century Medicine, vol. 31. London: The Wellcome Trust Centre for the History of Medicine at UCL
Clinical Research in Britain 1950-1980
No full textEdited transcript of a Witness Seminar held at the Wellcome Institute for the History of Medicine, London, on 9 June 1998. First published by the Wellcome Trust, 2000. ©The Trustee of the Wellcome Trust, London, 2000. All volumes are freely available online at www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edited transcript of a Witness Seminar held on 9 June 1998. Introduction by Dr David Gordon.Annotated and edited transcript of a Witness Seminar held on 9 June 1998. Introduction by Dr David Gordon.Annotated and edited transcript of a Witness Seminar held on 9 June 1998. Introduction by Dr David Gordon.Annotated and edited transcript of a Witness Seminar held on 9 June 1998. Introduction by Dr David Gordon.What is clinical research? The growth of clinical research in the UK since the Second World War is examined, including the 1953 Cohen Report and the subsequent creation of the Medical Research Council’s Clinical Research Board. Lord Walton of Detchant, as Chairman, guided the discussion on the inter-relationships between the MRC, the NHS, the Royal Colleges, other professional bodies and other funding organizations. Among other issues were the changes imposed by Government policy over the period, the influence of the early clinical research fellowships, growth of clinical career structures, planning of the Clinical Research Centre at Northwick Park, the tropical research units, and the effects of the Rothschild and Dainton reports on funding for clinical research and the role of the Chief Scientist. Participants include: Sir Douglas Black, Sir John Gray, Sir Raymond Hoffenberg, Dr Sheila Howarth, Professor Peter Lachmann, Sir Patrick Nairne, Professor Sir Stanley Peart and Dr Peter Williams. Reynolds L A, Tansey E M. (eds) (2000) Clinical research in Britain, 1950–1980, Wellcome Witnesses to Twentieth Century Medicine, vol. 7. London: The Wellcome Trust.The Wellcome Trust is a registered charity, no. 210183
The MRC Applied Psychology Unit
No full textThe transcript of a Witness Seminar held at the Wellcome Trust Centre for the History of Medicine at UCL, London, on 12 June 2001.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2003.©The Trustee of the Wellcome Trust, London, 2003. All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edited transcripts of a meeting held on 12 June 2001. Introduction by Geoff Bunn and Lois Reynolds.Annotated and edited transcripts of a meeting held on 12 June 2001. Introduction by Geoff Bunn and Lois Reynolds.Annotated and edited transcripts of a meeting held on 12 June 2001. Introduction by Geoff Bunn and Lois Reynolds.Annotated and edited transcripts of a meeting held on 12 June 2001. Introduction by Geoff Bunn and Lois Reynolds.Annotated and edited transcripts of a meeting held on 12 June 2001. Introduction by Geoff Bunn and Lois Reynolds.Annotated and edited transcripts of a meeting held on 12 June 2001. Introduction by Geoff Bunn and Lois Reynolds.This transcript considers the origins and impact of the MRC Applied Psychology Unit’s work from 1944 to 1998. Psychologists, clinicians, and industrial, ergonomic and occupational psychologists discuss the evolution of work from quite narrow postwar industrial and military concerns to more recent applications in, for example, ageing, dyslexia, depression, form design, information and semantics. Those who contributed included Professor Alan Baddeley, Dr Philip Barnard, Dr Ivan Brown, Professor Sergio Della Sala, Mr David C Duncan, Professor Richard Gregory (Chair), Professor John Groeger, Professor Graham Hitch, Professor Robert Logie, Dr Brandon Lush, Professor William Marslen-Wilson, Professor Peter McLeod, Professor Pat Rabbitt, Professor Graham Richards, Dr David Tyrrell, Professor John West. Introduction by Geoff Bunn and Lois Reynolds, 19 illus, biographical notes, subject and name index, 111pp. Reynolds L A, Tansey E M. (eds) (2003) The MRC Applied Psychology Unit, Wellcome Witnesses to Twentieth Century Medicine, vol. 16, London: The Wellcome Trust Centre for the History of Medicine at UCL.The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183
- …
