1,721,017 research outputs found
Metabolic competence to activate benzo(a)pyrene in murine epithelial cell lines with different degree of malignant transformation.
No full textUltrastructural studies of spontaneous in vitro transformation of cultured marrow monocyte-macrophage cells from a patient with congenital hypoplastic anemia
No full textThe CM-S cell line was established from the bone marrow of a patient suffering from congenital hypoplastic anemia (syndrome of Diamond-Blackfan). The cells grew in suspension in liquid culture and were dependent for their continuous replication in vitro on growth factors produced by the same cells seeded at high density. Initially, undifferentiated blasts, immature myeloid, megakaryocytic and, rarely, erythroid cells were observed. Eventually, a population of cells with characteristics of monocyte-macrophage precursors predominated. These cells could be induced to terminal macrophage differentiation by incubation with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. During this period (over 150 continuous passages), the cells failed to form colonies in agar and to give rise to tumors when inoculated into athymic mice. On prolonged passages, however, the cells gradually increased their growth capacity in liquid culture and became capable of forming colonies in agar and tumors in animals. Ultrastructural studies revealed that the expression of differentiated traits markedly changed as a function of time: after 277 passages, the transformed cells, although displaying characteristics of monocyte precursors, appeared blocked at this stage and no longer responded to 12-O-tetradecanoylphorbol-13-acetate
Terapia rigenerativa con cellule staminali
No full textL'uomo, pur essendo un animale microsmatico, ha sempre affidato all'olfatto importantissimi compiti per la propria sopravvivenza quali la difesa dai pericoli, la marcatura del territorio, la ricerca del cibo e la riproduzione. L'olfatto costituisce un modello privilegiato per lo studio e la comprensione dei processi molecolari della trasduzione dell'informazione sensoriale laddove la disosmia sembra avere un valore semeiotico forte come sintomo di allarme per molte malattie non solo rinosinusali ma anche neurodegenerative
Immunological monitoring of neuroblastoma. Serum mediated modulation of the immune response of murine spleen cells to syngeneic C1300 neuroblastoma cells.
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Anticorpi anti virus di Friend nel siero umano normale: specificità per la principale proteina virionica
No full textTumor-associated neural differentiation antigens detected on C1300 neuroblastoma cells by hybridoma monoclonal auto-antibodies.
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