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    Cognitive-behavioral treatment reduces attrition in treatment-resistant obese women: results from a 6-month nested case-control study

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    OBJECTIVE: The aim of this nested case-control study was to compare the effectiveness of cognitive-behavioral treatment (CBT) for treatment-resistant obese (body mass index [BMI] ≥30 kg/m2) women compared with standard dietary treatment. The main outcome measures were attrition and weight loss success. METHODS: We designed a 6-month case-control study, nested within a cohort of adult (age ≥18 years) treatment-resistant (history of at least two previous diet attempts) obese women. Cases were 20 women who were offered CBT sessions. Controls (n=39) were randomly selected from the source population and matched to cases in terms of baseline age, BMI, and number of previous diet attempts. RESULTS: Compared with controls, cases were significantly more likely to complete the 6-month program in both age-adjusted (odds ratio [OR]=2.94, 95% confidence interval [CI]=1.05–8.97) and multivariate-adjusted (OR=2.77, 95% CI=1.02–8.34) analyses. In contrast, cases were not more likely to achieve weight loss success in age-adjusted (OR=1.32, 95% CI=0.86–1.67) and multivariateadjusted (OR=1.21, 95% CI=0.91–1.44) analyses. CONCLUSIONS: Compared with a standard dietary treatment, CBT was significantly more effective in reducing attrition in treatment-resistant obese women, without differences in terms of weight loss success

    High frequency of psychopathology in subjects wishing to lose weight: an observational study in Italian subjects

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    OBJECTIVE: To investigate the frequency of psychiatric disorders in subjects wishing to lose weight categorized according to BMI. DESIGN: Cross-sectional study. SETTING: An academic outpatient clinical nutrition service in Italy. SUBJECTS: A total of 207 subjects (thirty-nine men and 168 women; mean age: 38.7 (sd 14.1) years) consecutively attending the study centre for the first time between January 2003 and December 2006. RESULTS: In the entire study group, eighty-three (40 %) subjects had a psychiatric disorder according to criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision. Eating disorders were the most prevalent psychiatric condition (thirty-six subjects, 17.4 %), followed by mood and anxiety disorders (9.7 % and 8.7 %, respectively). The frequency of psychiatric disorders among different BMI categories was as follows: 75.0 % in underweight, 50.0 % in normal weight, 33.3 % in overweight and 33.3 % in obese subjects. CONCLUSIONS: Psychiatric disorders may be frequently found in subjects wishing to lose weight. Our results highlight the importance of psychiatric assessment especially in underweight and normal-weight subjects
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