1,721,162 research outputs found
Pros and cons of bifunctional platinum(iv) antitumor prodrugs: two are (not always) better than one
No full textThe drug targeting and delivery approach applied to Pt-antitumour complexes. A coordination point of view
No full textThe Microscale Synthesis and Electrochemistry of Low-Valent Mononuclear Complexes (h3-C3H5)Fe(CO)3X (X = I, Br, Cl)
No full textElectrochemical studies of Ru(II) diimine bioconjugates
No full textThe electrochemical behavior of the ruthenium(II) diimine complexes [Ru(CO)(CF3CO2)(dppene)(5-R-phen)][PF6] (dppene = 1,2-diphenylphosphinoethene; phen = 1,10-phenanthroline; R = H, 1; R = NH2, 2; R = cholestoryl carbamate, 3; R = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine, 4), [Ru(CO)(H)(4,4′-R-bpy)(R′Ph2P)2][PF6] (bpy = 2,2′-bipyridine; R = H, R′ = Ph, 5; R = H, R′ = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine, 6; R = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine, R′ = Ph, 7), [Ru(bpy)2(5-R-phen)][PF6]2 (R = NH2, 8; R = cholestoryl carbamate, 9; R = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine, 10) is reported. Complexes 1-6 give cyclovoltammetric (CV) responses with multiple ill-defined reduction waves and one oxidation wave, all of which were chemically irreversible. Complexes 5 and 7, containing axially coordinating phosphines, showed reversible oxidation and reduction CV responses, while 6 showed redox waves similar to 3. Complexes 8-10 show a metal-centered irreversible oxidation around +1.4 V that, in the case of 8 and 9, is heavily modified by adsorption phenomena. In the negative part of the CV, 9 and 10 show a single chemically and electrochemically reversible 1e- reduction both at E°′ = -1.29 V, about 500 mV cathodically shifted with respect to 8. The interactions of complexes 1 and 2 with bovine serum albumin (BSA) and double stranded DNA (ds-DNA) were also studied by electrochemical methods. Both complexes showed strong binding to BSA. Evidence for intercalation of both complexes with DNA is presented, with 1 showing a stronger interaction than 2. © 2015 Elsevier B.V. All rights reserved.
Probing Delocalisation Across Highly Ethynylated Mono and Dinuclear Pt(II) tethers Containing Nitrogroups and Organic Models as Redox Active Probes. X-ray crystal structure of trans-[Pt(C=C-C6H4NO2)2(PPh3)2]
No full textSynthesis and in-vitro cytotoxicity of cis,cis,trans-diammine dichlorido disuccinatoplatinum(IV)-peptide bioconjugates
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Relationship Between Ligand Structure and Electrochemical and Relaxometric Properties of Acyclic Poly(aminocarboxylate) Complexes of Eu(II)
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