1,721,076 research outputs found
Sensory feedback for limb prostheses in amputees
No full textCommercial prosthetic devices currently do not provide natural sensory information on the interaction with objects or movements. The subsequent disadvantages include unphysiological walking with a prosthetic leg and difficulty in controlling the force exerted with a prosthetic hand, thus creating health issues. Restoring natural sensory feedback from the prosthesis to amputees is an unmet clinical need. An optimal device should be able to elicit natural sensations of touch or proprioception, by delivering the complex signals to the nervous system that would be produced by skin, muscles and joints receptors. This Review covers the various neurotechnological approaches that have been proposed for the development of the optimal sensory feedback restoration device for arm and leg amputees
Spatial and Functional Selectivity of Peripheral Nerve Signal Recording With the Transversal Intrafascicular Multichannel Electrode (TIME)
No full textReal-time open-loop control of dielectric elastomer actuators via bioelectric and biomechanical signals
No full textA computational model for the stimulation of ratsciatic nerve using a transverse intrafascicularmultichannel electrode
No full textNeuroprostheses based on electrical stimulation
could potentially help disabled persons. They are based on
neural interface that aim at creating an intimate contact with
neural cells. The efficacy of neuroprostheses can be improved by
increasing the selectivity of the neural interfaces used to stimulate
specific subsets of cells. Selectivity is strongly influenced by interface
design. Computer models can be useful for exploring the high
dimensional space of design parameters with the aim to provide
guidelines for the development of more efficient electrodes, with
minimal animal use and optimization of manufacturing processes.
The purpose of this study was to implement a realistic model
of the performance of a transverse intrafascicular multichannel
electrode (TIME) implanted into the rat sciatic nerve. A realistic
finite element method (FEM) model was developed taking into
account the anatomical and physiological features of the rat
sciatic nerve. Electric potentials were calculated and interpolated
voltages were applied to the model of a rat sciatic nerve axon,
based on experimental biophysical data. Results indicate that
high intra-fascicular and inter-fascicular selectivity values with
low current levels can be achieved with TIMEs. The selectivity of
TIMEs was also compared to one of the extraneural electrodes,
showing that higher selectivity with less current can be obtained.
Using this model, the robustness of electrode performances for
translational and rotational displacements were evaluated
On the identification of sensory information from mixed nerves by using single-channel cuff electrodes
No full textExperimental validation of a hybrid computationalmodel for selective stimulation using transverseintrafascicular multichannel electrodes
No full textRecently a hybrid model based on the finite element method and on a compartmental biophysical representation of peripheral nerve fibers and intraneural electrodes was developed founded on experimental physiological and histological data. The model appeared to be robust when dealing with uncertainties in parameter selection. However, an experimental validation of the findings provided by the model is required to fully characterize the potential of this approach. The recruitment properties of selective nerve stimulation using transverse intrafas- cicular multichannel electrodes (TIME) were investigated in this work in experiments with rats and were compared to model predictions. Animal experiments were performed using the same stimulation protocol as in the computer simulations in order to rigorously validate the model predictions and understand its limitations. Two different selectivity indices were used, and new indices for measuring electrode performance are proposed. The model predictions are in decent agreement with experimental results both in terms of recruitment curves and selectivity values. Results show that these models can be used for extensive studies targeting electrode shape design, active sites shape, and multipolar stimulation paradigms. From a neurophysiological point of view, the topographic organization of the rat sciatic nerve, on which the model was based, has been confirmed
Does multipolar stimulation enhance selectivity of the TIME electrode? A simulation study using a genetic algorithm
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Finite element and biophysics modelling of intraneural transversal electrodes: Influence of active site shape.
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