635 research outputs found
Letter and cables to P.R.S. Mani from S. Sadanand (Editor, Free Press Journal), 1946
No full textLetters and cables contain correspondence between Mr S. Sadanand (editor and founder of Free Press Journal), and P.R.S. Mani. Contents relate to articles written by P.R.S. Mani and Free Press Journal editorial policy, particularly in relation to identifying authors (with bylines as was then the American practice – Sadanand refuses Mani’s request for such identification) and to setting up a consolidated news office in Singapore. Mani is confirmed as FPJ correspondent for Malaya and Singapore.
1 Apr 46: Approval of Mani’s initial information on rice offer.
Five cables (unspecified dates) Sadanand to Mani: requesting confirmation of rice offer. Convey’s Nehru’s request for Mani to locate Indian Major in British Army, Inderjit Singh, missing believed killed 25 October 1945. Sadanand asks Mani to organize PM Sjahrir to make direct official statement to confirm rice offer either to Indian Government (ie British) or to Mani himself.
11 May 46: praise for Mani’s rice negotiations and scoop but refusal of Mani’s request for byline identification of himself as author. ‘Unacknowledging names of correspondents part of our cardinal policy’.
1 Aug 1946, Sadanand to Mani via Singapore Office, re organization and setting up of new Singapore office.</p
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Acute activation of conserved synaptic signaling pathways in Drosophila melanogaster
No full textStudies of memory have identified several memory classifications: declarative, implicit, working, and anesthesia-resistant. One simple classification that may be applied to the array of model systems now used to explore memory is the requirement for de novo gene expression and protein synthesis for the formation of long-term memory (LTM). Short-term memory (STM) appears to require the modification of pre-existing neuronal molecules and is resistant to inhibitors of protein synthesis. These molecules, believed to encode proteins that effect long-lasting neuronal changes likely at the level of the synapse, are manifested behaviorally as memory. Neural activity regulates the cellular decision to synthesize these molecules, yet the identity and function of these molecules are largely unknown. What is known has largely been elucidated by work in mollusks and vertebrates in which procedures have been developed to generate neural activity sufficient to induce long-lasting, protein synthesis-dependent neuronal plasticity. Using these procedures, several key intracellular signaling pathways (Ras/ERK, cAMP/PKA) and important early gene products (arc, zif268, AP1) critical to memory have been identified. Similar procedures are not presently available in Drosophila. Establishing these procedures would greatly enhance the Drosophila model system for identification of plasticity molecules and mechanisms that control their expression. We have explored the potential of conditional Drosophila seizure mutants of comatose and CaP60A mutants for the development of a neural activity generation paradigm capable of (1) inducing long lasting and robust neural activity; (2) acute and persistent activation of the ERK signaling pathway and induction of Drosophila homologs of immediate early genes known to be involved in plasticity; (3) alteration of synaptic localization of fasciclin II, a known effector of synaptic plasticity. Using these mutants, we have established the conservation in insects of a known neural activity regulated signaling pathway shown to be critical to both long term plasticity and memory. Secondly, we have identified a central role for AP1, a classical activity induced gene, in regulating Drosophila neural plasticity. The neural activity paradigm coupled with the identification AP1 dual control of both major branches of long term neuronal change, structural and functional plasticity, provides researchers valuable tools for addressing some the outstanding questions facing the plasticity field today
Recoding world literature : libraries, print culture, and Germany's pact with books /
No full textFrom the current vantage point of the transformation of books and libraries, B. Venkat Mani presents a historical account of world literature. By locating translation, publication, and circulation along routes of "bibliomigrancy"--The physical and virtual movement of books - Mani narrates how world literature is coded and recoded as literary works find new homes on faraway bookshelves. Mani argues that the proliferation of world literature in a society is the function of a nation's relationship with print culture - a Faustian pact with books. Moving from early Orientalist collections, to the Nazi magazine Weltliteratur, to the European Digital Library, Mani reveals the political foundations for a history of world literature that is at once a philosophical ideal, a process of exchange, a mode of reading, and a system of classification. Shifting current scholarship's focus from the academic to the general reader, from the university to the public sphere, 'Recoding World Literature' argues that world literature is culturally determined, historically conditioned, and politically charged.From the current vantage point of the transformation of books and libraries, B. Venkat Mani presents a historical account of world literature. By locating translation, publication, and circulation along routes of "bibliomigrancy"--The physical and virtual movement of books - Mani narrates how world literature is coded and recoded as literary works find new homes on faraway bookshelves. Mani argues that the proliferation of world literature in a society is the function of a nation's relationship with print culture - a Faustian pact with books. Moving from early Orientalist collections, to the Nazi magazine Weltliteratur, to the European Digital Library, Mani reveals the political foundations for a history of world literature that is at once a philosophical ideal, a process of exchange, a mode of reading, and a system of classification. Shifting current scholarship's focus from the academic to the general reader, from the university to the public sphere, 'Recoding World Literature' argues that world literature is culturally determined, historically conditioned, and politically charged.Introduction : world literature as a pact with books -- 1. Of masters and masterpieces : an empire of books, a mythic European library -- 2. Half epic, half drastic : from a parliament of letters to a national library -- 3. The shadow of empty shelves : two world wars and the rise and fall of world literature -- 4. Windows on the Berlin Wall : unfinished histories of world literature in a divided Germany -- 5. Libraries without walls? World literature in the digital century -- Epilogue.Includes bibliographical references (pages 309-336) and index.JSTO
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Genetic analysis of endocytosis at the Drosophila synapse
No full textEndocytosis plays an essential role in maintaining a pool of synaptic vesicles for sustained neurotransmitter release. Synaptic vesicles are internalized and fuse with endosomes, and are subsequently reassembled to be ready for another round of exocytosis. Here I describe in two distinct studies the function of endosomes at synapses and regulation of dynamin, a protein essential for endocytosis, using the Drosophila synapse as a model. To study the function of endosomes at synapses I analyzed the localization and function of two Drosophila endosomal proteins, Hook and Deep orange (Dor), at the larval neuromuscular junction. I present here the first genetic evidence of a role for endocytic trafficking in plasticity of the synapse. I also found that mutations in hook and dor affect the number of varicosities at the nerve terminal without affecting synaptic vesicle recycling, indicating that Hook and Dor proteins play a role in later stages of endocytosis at the synapse. Dynamin is a GTPase that is essential for internalization of synaptic vesicles from the plasma membrane. Flies carrying shi ts mutations have a conditional defect in dynamin function. Molecules that regulate GTP loading (guanine-nucleotide exchange factors-GEFs) and GTPase activity (GTPase activating proteins-GAPs) of dynamin are unknown. Here I describe the identification of such molecules/domains by analyses of enhancer and suppressor mutations identified in previously conducted genetic screens. I show here that the enzymatic activity of Nucleoside diphosphate kinase (NDP Kinase), a source of GTP encoded by the Drosophila abnormal wing discs (awd) or human nm23 tumor suppressor genes, is essential for dynamin function at synapses. Dynamin is also regulated by an intramolecular GTPase effector domain (GED) and I have identified separate mutations in shi, which map to the GED, that suppress endocytic defects in shits2. Overall, these data indicate a model in which the stability of dynamin: GTP is opposingly regulated by an unusual GEF activity of NDP kinase and a GAP activity in dynamin; in addition these findings indicate the possibility of an intriguing therapy for nm23 tumor progression
Investigating mechanisms underlying olfactory habituation in Drosophila melanogaster
No full textTHESIS 8898Habituation is a common form of learning and memory that has been poorly studied
despite its fundamental importance and clinical significance. During habituation, the
behavioural response to a prolonged or repeated unreinforced stimulus is attenuated.
Drosophila melanogaster is a particularly useful model system in which to study
olfactory habituation, due to the well-understood olfactory circuitry and availability of a wide array of genetic tools
Olfactory-avoidance habituation in Drosophila melanogaster
No full textTHESIS 11028Habituation is a form of sensory filtering in response to prolonged or repeated stimuli in the environment [Harris, 1943; Thompson and Spencer, 1966; Christoffersen, 1997; Rankin et al., 2009], It provides biological organisms with a means of ignoring non-salient aspects of the local environment in order to selectively focus on stimuli that are potentially more relevant e.g. those associated with danger or a food source. Though habituation is one of the simplest form of memory, it is likely an important building block for more complex forms of learning [Fabiani et al., 2006; Rankin et al., 2009]
A proposito di diritti umani. Ci salvi il Giudice Costituzionale dalla disumana inutilità del divieto di cuocere cibi per il detenuto in regime di 41-bis.
No full textL’Autrice esamina la questione di legittimità costituzionale dell’art. 41-bis, co. 2-quater, lett f ) ord.
pen., nella parte in cui impone che siano adottate tutte le necessarie misure di sicurezza volte a
garantire che sia assicurata la assoluta impossibilità per i detenuti in regime differenziato di cuocere
cibi. Nello specifico si mette in luce come l’aspetto relativo al regime alimentare dei detenuti
sottoposti al trattamento differenziato ex art. 41-bis ord. penit. sia trascurato dell’ordinamento
penitenziario, e perciò doveroso un intervento del Giudice Costituzionale.The author examines the question of the constitutionality of art. 41-bis, co. 2-quarter, lett f ) ord. pen.,
insofar as it requires to be taken all necessary security measures to ensure that it is secured the absolute
impossibility for prisoners in differentiated regime to cook foods. Specifically, highlights how the look on
the diet of prisoners subjected to differential treatment ex art. 41-bis ord. penit. both overlooked the sort of
intervention, and so dutiful penitentiary Constitutional Court
Inter institutional workshop on breakwaters
No full text(1) Functional requirements for Breakwaters - Prof. K.d' Angremond (2) Development of fishery harbors in India - Mr. K. Omprakash (3) Non-rubble Breakwaters and optimisation - Prof. K.d' Angremond (4) Wave energy caisson Breakwaters - Dr. S. Neelamani (5) Partially suspended porous wall Breakwaters - Dr. J.S. Mani (6) Case studies on stability of Breakwaters - Prof. V. Sundar (7) Introduction on Ennore coal port project - Mr. L.A. Mayboom (8) Design of Breakwaters for Ennore port - Mr. R. Haggie (9) Construction of Breakwaters for Ennore port - Mr. S. PearsonHydraulic EngineeringCivil Engineering and Geoscience
La detenzione intramuraria “obbligata” del soggetto affetto da grave infermità psichica e l’assenza di strumenti alternativi idonei ad assicurare un trattamento conforme ai principi costituzionali e convenzionali
No full textL’Autrice esamina la questione di legittimità costituzionale dell’art. 47-ter, comma 1-ter ord. pen. nella parte in cui detta previsione di legge non prevede l’applicazione della detenzione domiciliare anche nelle ipotesi di grave infermità psichica sopravvenuta durante l’esecuzione della pena. In particolare, si evidenziano le criticità della normativa penitenziaria con riferimento specifico all’assenza di strumenti alternativi alla detenzione carceraria per il detenuto in esecuzione pena con residuo superiore a quattro anni, affetto da grave patologia psichica sopravvenuta, stante l’inapplicabilità sia degli artt. 146, 147 e 148 c.p. sia della detenzione domiciliare c.d. “umanitaria” ex art. 47-ter comma 1-ter ord. pen., in as-senza di rinvio –nella citata disposizione di legge- alla norma di cui all’art. 148 c.p.The Author examines the question of the constitutionality of art. 47-ter, comma 1-ter ord. pen. in the part in which this provision of law does not provide for the application of domicile detention even in cases of serious psychic infirmity occurred during the execution of the sentence. In particular, we hi-ghlight the criticality of the prison legislation with specific reference to the absence of alternative tools to imprisonment for the inmate in pain under penalty of over four years, suffering from serious psychic pathology occurred, given the inapplicability of both articles. 146, 147 and 148 c.p. both of the domici-liary detention c.d. "Humanitarian" ex art. 47-ter paragraph 1-ter ord. pen., in the absence of a reference - in the aforementioned provision of the law - to the norm referred to in art. 148 p.p.
The strange case of the Turkish and Venetian judges in eighteenth-century Mani wall paintings
No full textInvestigating church wall paintings in Mani, Greece, the author identified a common theme of the Ainoi, the graphic interpretation of Psalms 148-150. Within this scheme there is often a specific depiction of the 'Judges of the Earth' as an Ottoman judge and a Venetian nobleman. This depiction is unique to Mani and is restricted to the mid-eighteenth century and those areas of Mani dominated by the rule of the kapetanoi. The paintings allude to the lack of established legal systems in that period of Mani's history and refer back to times of stable law under Ottoman and Venetian rule
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