127,468 research outputs found
Crystallography and crystal perfection, par G. N. Ramachandran, 1963
No full textHerpin Paulette. Crystallography and crystal perfection, par G. N. Ramachandran, 1963. In: Bulletin de la Société française de Minéralogie et de Cristallographie, volume 87, 3, 1964. p. 468
Advanced methods of crystallography, par G. N. Ramachandran, 1964
No full textWyart Jean. Advanced methods of crystallography, par G. N. Ramachandran, 1964. In: Bulletin de la Société française de Minéralogie et de Cristallographie, volume 88, 4, 1965. p. 716
Advanced methods of crystallography, par G. N. Ramachandran, 1964
No full textWyart Jean. Advanced methods of crystallography, par G. N. Ramachandran, 1964. In: Bulletin de la Société française de Minéralogie et de Cristallographie, volume 88, 4, 1965. p. 716
A proposed case for the Cloud Software Engineering in Security
No full textThis paper presents Cloud Software Engineering in Security (CSES) proposal that combines the benefits from each of good software engineering process and security. While other literature does not provide a proposal for Cloud security as yet, we use Business Process Modeling Notation (BPMN) to illustrate the concept of CSES from its design, implementation and test phases. BPMN can be used to raise alarm for protecting Cloud security in a real case scenario in real-time. Results from BPMN simulations show that a long execution time of 60 hours is required to protect real-time security of 2 petabytes (PB). When data is not in use, BPMN simulations show that the execution time for all data security rapidly falls off. We demonstrate a proposal to deal with Cloud security and aim to improve its current performance for Big Data
T. N. Ramachandran : Buddhist sculptures from a stūpa near Goli village, Guntur district
No full textCœdès Georges. T. N. Ramachandran : Buddhist sculptures from a stūpa near Goli village, Guntur district. In: Bulletin de l'Ecole française d'Extrême-Orient. Tome 29, 1929. p. 440
Financial software as a service – a paradigm for risk modelling and analytics
No full textSoftware as a service as one of the cloud delivery models that supports fine-grained components. Financial applications demand better performance and accuracy in a cloud than the traditional computing platforms. Therefore, designing financial software as a service (FSaaS) requires an engineering and systematic approach. This paper has proposed an integrated service-oriented architecture and a SaaS component model for financial domain that provides the required scalability, flexibility and customisation. We have also demonstrated the design and customisation of service component interfaces to a financial simulation so that it provides automatic prediction models for investors to know accurate results for buy and sale prices. Therefore, large-scaled simulations can be achieved within a matter of 13.5 second for outlier removal and within 9 seconds for high-performance risk computation on the Cloud. We show the holistic and complete approach of illustrating the system design of FSaaS, showing the two major algorithms and the results of experiments of running these two algorithms. We provide plans to integrate new and existing services with FSaaS
The legacy of G. N. Ramachandran and the development of structural biology in India
No full textG. N. Ramachandran is among the founding fathers of structural molecular biology. He made pioneering contributions in computational biology, modelling and what we now call bioinformatics. The triple helical coiled coil structure of collagen proposed by him forms the basis of much of collagen research at the molecular level. The Ramachandran map remains the simplest descriptor and tool for validation of protein structures. He has left his imprint on almost all aspects of biomolecular conformation. His contributions in the area of theoretical crystallography have been outstanding. His legacy has provided inspiration for the further development of structural biology in India. After a pause, computational biology and bioinformatics are in a resurgent phase. One of the two schools established by Ramachandran pioneered the development of macromolecular crystallography, which has now grown into an important component of modern biological research in India. Macromolecular NMR studies in the country are presently gathering momentum. Structural biology in India is now poised to again approach heights of the kind that Ramachandran conquered more than a generation ago
Sexually immature male ERE-Luc reporter mice to assess low dose estrogen-like effects of CdCl2 versus dietary Cd
No full textCdCl2 salt is widely used in exposure oriented studies, while the biological exposure of Cadmium (Cd) occurs mostly through diet. Hence, we designed a in vivo imaging methodology with sexually immature male ERE-Luc reporter mice to test the estrogen-like (EL) effects of Cd as a natural component in wheat and flax bread based diets (containing 17.57 and 49.22 ug/kg Cd concentrations respectively) and CdCl2 per-oral dose of 1 ug/kg/bw/day. Total exposure of ingested and % bioaccumulation of Cd in selected organs were estimated as 547 ng (4.4%), 776 ng (0.3%) and 2131.8 ng (0.1%) corresponding to CdCl2, wheat and flax bread based diet treatments respectively. Cd from CdCl2 bioaccumulated more readily, despite the exposure of Cd is higher with bread based diets. Longitudinal in vivo imaging did not reveal significant changes in luciferase activity. White adipose tissue (WAT) and prostate were identified as novel target organs of Cd. Indeed, the rest of the observed EL effects, endogenous target gene expression and necropsy findings are not consistent to any particular organ or treatment. This implies that, the observed EL effects due to low doses of Cd (either from CdCl2 or dietary form) occur only as subtle changes at the molecular level, but inadequate to cause significant changes at the anatomo-pathological level during the 21 day exposure period. The study demonstrates the sensitivity of the methodology to assess EL effects of food embedded Cd and underlines the limitations of directly extrapolating the results of suspected chemicals in their pure form to dietary exposure scenarios
The Ramachandran Plots Of Glycine And Pre-Proline
No full textpeer reviewedBACKGROUND: The Ramachandran plot is a fundamental tool in the analysis of
protein structures. Of the 4 basic types of Ramachandran plots, the interactions
that determine the generic and proline Ramachandran plots are well understood.
The interactions of the glycine and pre-proline Ramachandran plots are not.
RESULTS: In glycine, the psi angle is typically clustered at psi = 180 degrees
and psi = 0 degrees. We show that these clusters correspond to conformations
where either the N(i+1) or O atom is sandwiched between the two Halpha atoms of
glycine. We show that the shape of the 5 distinct regions of density (the alpha,
alphaL, betaS, betaP and betaPR regions) can be reproduced with electrostatic
dipole-dipole interactions. In pre-proline, we analyse the origin of the zeta
region of the Ramachandran plot, a region unique to pre-proline. We show that it
is stabilized by a CO(i-1)...CdeltaHdelta(i+1) weak hydrogen bond. This is
analogous to the CO(i-1)...NH(i+1) hydrogen bond that stabilizes the gamma region
in the generic Ramachandran plot. CONCLUSION: We have identified the specific
interactions that affect the backbone of glycine and pre-proline. Knowledge of
these interactions will improve current force-fields, and help understand
structural motifs containing these residues
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