32,526 research outputs found
The Strategies for Simple One-Point Ko Situation of Computer Go
No full text[[abstract]]Ko plays a very important role in Go, but most computer Go programs still cannot handle ko fights so far. Utilizing the principle of Minimax procedure, we obtain the best strategies for the simple one-point ko situation, enabling computer Go programs to gain maximum or loss minimum profit when dealing with the simple one-point ko situation. We also discuss in detail the strategies for using ko threats during the process of the ko fight.
ko-ax photo [Selected by Tate Curator of Photography, Simon Baker]
No full textko-ax photo was an open submission competition selected by Simon Baker (Curator of Photography, Tate), Sue Steward (Photography critic, Telegraph, Observer, Guardian, BBC) and John Gill (Curator Brighton Photo Biennial and Founder Photoworks). The 10 artists selected all presented fascinating artworks that conceal narratives and ask questions of the viewer. Questions of beauty, family, decay and fantasy were all explored across over 50 works.</p
Memorandum from R. Galaida to Mr. Ko regarding Hsuanhwatien (Xuanhuadian) [China] farms tool supplies, August 5,1946
No full textA memorandum, dated as August 5, 1946, from R. Galaida to Mr. Ko, regarding the farms tool supplies to Hsuanhwatien (Xuanhuadian) District.Communist Territor
Summary of 3 field missions to Hsuanhwatien (Xuanhuadian) [China], R. Galaida's handwritten memorandum to Mr. Ko on July 31, 1946
No full textA handwritten memorandum from R. Galaida to Mr. Ko on July 31, 1946, regarding the summary of 3 field missions to Hsuanhwatien (Xuanhuadian).Communist Territor
MM activity and glucose metabolism in IL-1-KO mice during R+G+.
No full text<p>(A) IL-1-KO-MMs were easily fatigued in the R+G+ condition. WT and IL-1-KO mice (n = 12) were subjected to R+G+, and the MM activity was measured. Typical examples of plastic plates gnawed on during R+G+ by WT or IL-1-KO mice are shown on the right. Experimental values are given as the mean ± SE. *<i>P</i> < 0.05 compared to WT at the same time-points. (B) Effects of R+G+ on blood glucose. There was no difference in blood glucose levels between WT and IL-1-KO mice during R+G+ behavior. WT and IL-1-KO mice (n = 4–5) were subjected to R+G+, and blood was taken from the tail vein for blood glucose measurement. (C) Glycogen stores in IL-1-KO-MMs were strongly depleted during R+G+. WT and IL-1-KO mice (n = 12–16) were subjected to 1 h of R+G+ behavior or of R+G-, and MM glycogen content was measured. MMs from R-G- (i.e., resting, unrestrained) mice were also analyzed as a control. (D) Glucose uptake by IL-1-KO MMs (Left) was less than by WT MMs during R+G+, but not by the quadriceps femoris muscles (QFM, Right). WT and IL-1-KO mice (n = 10–12) were intraperitoneally injected with <sup>14</sup>C-2DG after 1 h of R+G+ activity, and 30 min later skeletal muscles were removed and glucose uptake was measured. Experimental values are given as the mean ± SE. *<i>P</i> < 0.05, **<i>P</i> < 0.01.</p
CCHFV infection of TNFA-R DBL KO mouse livers.
No full textA. Representative H&E staining of TNFA-R DBL KO mice on day 10 showing mitotic figures (arrows), indicative of liver recovery/regenerative response. B. Representative liver section from a day 10 infected TNF-R DBL KO mouse were stained with anti-CLEC4F (red) and anti-CCHFV N protein (green) antibodies. Cell nuclei were stained with DAPI (TIF)</p
Organizational Learning and Marketing Capability Development: A Study of Charity Retailing Operation of British Social Enterprises
No full textSocial enterprise is a hybrid form of profit- and social benefit-seeking organization whereby traditional nonprofit organizations pursue both their social mission and business opportunities. To embrace this new strategic direction shift, the nonprofit organizations need to develop new competences that will enable them to respond to the changes in the business model. The article investigates the learning mechanisms through which social enterprises develop a marketing capability to deploy their resources in the marketplace as the drivers of competitive advantage in their commercial practice. We study eight cases of UK-based charity retailers, in order to address the role of knowledge accumulation, articulation and codification process in the evolution of marketing capability development. We identify, amongst other things that the critical process of organizational learning for social enterprise is to transfer the experience into organization specific knowledge under the social aspects of constraints
The people behind the papers – Jason Ko and Daniel Lobo
No full textPlanarians grow when they are fed and shrink during periods of starvation. However, it is unclear how they maintain appropriate body proportions as their size changes. A new paper in Development investigates the differences between growth and shrinkage dynamics and builds a mathematical model to explore the mechanisms underpinning these two processes. To learn more about the story behind the paper, we caught up with first author, Jason Ko, and corresponding author, Daniel Lobo, Associate Professor at the University of Maryland.https://doi.org/10.1242/dev.20298
Comparative lipidomic profiling of plasma and aorta from ldlr-KO, pcsk9-KO and C57bl/6 mice
No full textBackground. Lipidomics is a powerful tool to highlight the involvement of lipid species in pathological conditions, including atherosclerosis.
Aim. Lipidomic changes induced by genotype and/or diet were evaluated in plasma and aorta of hyperlipidemic/athero-prone Ldlr-KO, hypolipidemic/athero-resistant Pcsk9-KO and C57Bl/6 (WT) mice.
Methods. Plasma and aorta from mice fed chow or Western diet (WD) for 16 weeks were extracted for lipids and analyzed by mass spectrometry: 200 lipid species belonging to 21 lipid classes were quantified.
Results. On chow diet, plasma lipidome was lower in Pcsk9-KO (2039 μM) vs WT mice (3770 μM) and was much higher in Ldlr-KO (9392 μM) vs WT and Pcsk9-KO mice. WD increased with different degree all lipid classes in each group and the lipidome increased by 2-3 fold in Pcsk9-KO and WT mice and by 5 fold in Ldlr-KO mice. The lipids quantitatively more relevant in each group and dietary condition were cholesteryl esters (CE), phosphatidylcholines, free cholesterol and triglycerides. Among minor lipid species, interestingly, Ceramides(d18:0) levels on chow diet were comparable in Pcsk9-KO and WT mice and were moderately increased by WD, whereas they were 10 fold higher in Ldlr-KO mice on chow diet vs the other groups and increased by another 10 fold on WD. Aorta lipidome of Pcsk9-KO mice was unaffected by diet (chow: 20.7 pmol/μg; WD: 20.2 pmol/μg) whereas it was increased by WD in WT (chow: 18.2 pmol/μg; WD: 38.7 pmol/μg) and Ldlr-KO mice (chow: 19.7 pmol/μg; WD: 49.9 pmol/μg). Among major lipids, WD drastically affected CE concentration in Ldlr-KO mice (chow: 0.1 pmol/μg, WD: 5.3 pmol/μg), whereas it only doubled CE levels in Pcsk9-KO and WT mice. Triglycerides were unaffected by diet in Pcsk9-KO mice, but increased by 2.5 fold with WD in both WT and Ldlr-KO mice. WD did not substantially modify minor lipids in Pcsk9-KO and WT mice, whereas it drastically changed phosphatidylglycerol, glucosyl/galactosylceramides and Lactosylceramides levels in Ldlr-KO aorta.
Conclusions. This lipidomic profiling indicates that diet and/or a genetic background can drastically affect not only major lipid classes, but also minor lipid species, suggesting a possible implication of these molecules in hyperlipidemia and atherosclerosis development
Memorandum from R. Galaida to Mr. Ko regarding Korean Prisoners of War - Hanyang [China], May 23,1946
No full textA memorandum from R. Galaida to Mr. Ko regarding health problems with Korean prisoners of War, May 23,1946. It is noted as "CNRRA-091".Action – Applications for Relie
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