762 research outputs found
Short- and long-term safety of weekly high-dose vitamin D3 supplementation in school children
No full textBackground: Hypovitaminosis D is prevalent in youth worldwide, but the safety of vitamin D at doses exceeding 200 IU-d is unknown in this age group. We assessed the safety of high doses of vitamin D3 administered to apparently healthy schoolchildren. Methods: To assess short-term safety, 25 subjects randomly received placebo or vitamin D3 at doses of 14,000 IU-wk for 8 wk. To assess long-term safety, 340 subjects randomly received placebo, vitamin D3 as 1,400 IU-wk or 14,000 IU-wk for 1 yr. Biochemical variables were monitored at 0, 2, 4, 6, and 8 wk and 8 wk off therapy in the short-term study and at 0, 6, and 12 months in the long-term study. Results: In both the short- and long-term studies, mean serum calcium and 1,25-hydroxyvitamin levels did not change in any group. In the short-term study, mean 25-hydroxyvitamin concentrations increased from 44 (± 11) to 54 (± 19) ng-ml in the treated groups (P = 0.033). In the long-term study, mean 25-hydroxyvitamin D levels increased from 15 ± 8 to 19 ± 7 ng-ml (P andlt; 0.0001) in subjects receiving 1,400 IU-wk and from 15 ± 7 to 36 ± 22 ng-ml (P andlt; 0.0001) in the group receiving 14,000 IU-wk. No subject developed vitamin D intoxication. Conclusion: Vitamin D 3 at doses equivalent to 2000 IU-d for 1 yr is safe in adolescents and results in desirable vitamin D levels. Copyright © 2008 by The Endocrine Society.AKSNES L, 1982, J CLIN ENDOCR METAB, V55, P94; Armas LAG, 2004, J CLIN ENDOCR METAB, V89, P5387, DOI 10.1210-jc.2004-0360; Binkley N, 2004, J CLIN ENDOCR METAB, V89, P3152, DOI 10.1210-jc.2003-031979; Chel V, 2008, OSTEOPOROSIS INT, V19, P663, DOI 10.1007-s00198-007-0465-2; *COMM SCI EV DIET, 1997, DIET REF INT CAL PHO; *COMM SCI EV DIET, 1999, DIET REF INT CALC PH; Baker SS, 1999, PEDIATRICS, V104, P1152; Dahifar Hossein, 2006, J Med Invest, V53, P204, DOI 10.2152-jmi.53.204; Dawson-Hughes B, 2005, OSTEOPOROSIS INT, V16, P713, DOI 10.1007-s00198-005-1867-7; Docio S, 1998, J BONE MINER RES, V13, P544, DOI 10.1359-jbmr.1998.13.4.544; El-Hajj Fuleihan G, 2001, PEDIATRICS, V107, P1; Fuleihan GE, 2006, J CLIN ENDOCR METAB, V91, P405, DOI 10.1210-jc.2005-1436; FULEIHAN GEH, 2007, NUTR ASPECTS OSTEOPO, V1297, P91; Gartner LM, 2003, PEDIATRICS, V111, P908, DOI 10.1542-peds.111.4.908; GLASTRE C, 1990, J CLIN ENDOCR METAB, V70, P1330; Gordon CM, 2004, ARCH PEDIAT ADOL MED, V158, P531, DOI 10.1001-archpedi.158.6.531; Guillemant J, 1999, OSTEOPOROSIS INT, V10, P222, DOI 10.1007-s001980050219; Guillemant J, 1995, BONE, V17, P513, DOI 10.1016-8756-3282(95)00401-7; Guillemant J, 2001, OSTEOPOROSIS INT, V12, P875, DOI 10.1007-s001980170040; Hathcock JN, 2007, AM J CLIN NUTR, V85, P6; Heaney RP, 2003, AM J CLIN NUTR, V78, P912; Holick MF, 2007, NEW ENGL J MED, V357, P266, DOI 10.1056-NEJMra070553; Holick MF, 2006, MAYO CLIN PROC, V81, P353; Hollis BW, 2004, J CLIN ENDOCR METAB, V89, P3149, DOI 10.1210-jc.2004-0682; Houghton LA, 2006, AM J CLIN NUTR, V84, P694; ILICH JZ, 1997, CALCIFIED TISSUE INT, P61104; Knight JA, 2007, CANCER EPIDEM BIOMAR, V16, P422, DOI 10.1158-1055-9965.EPI-06-0865; Lips P, 1999, OSTEOPOROSIS INT, V9, P394, DOI 10.1007-s001980050162; Lips P, 2004, J STEROID BIOCHEM, V89-90, P611, DOI 10.1016-j.jsbmb.2004.03.040; LOCKITCH G, 1988, CLIN CHEM, V34, P1622; Luscombe CJ, 2001, LANCET, V358, P641, DOI 10.1016-S0140-6736(01)05788-9; MAALOUF J, 2005, BONE S1, V36, pS50; Maalouf J, 2006, J BONE MINER RES, V21, pS29; Matkovic Velimir, 2005, American Journal of Clinical Nutrition, V81, P175; Oliveri B, 1996, EUR J CLIN NUTR, V50, P807; OLIVERI MB, 1993, BONE MINER, V20, P99, DOI 10.1016-S0169-6009(08)80041-4; Pittas AG, 2006, DIABETES CARE, V29, P650, DOI 10.2337-diacare.29.03.06.dc05-1961; Trang HM, 1998, AM J CLIN NUTR, V68, P854; VIETH R, 1990, AM J PHYSIOL, V258, pE780; Vieth R, 1999, AM J CLIN NUTR, V69, P842; Vieth Reinhold, 2004, Nutr J, V3, P8, DOI 10.1186-1475-2891-3-8; Vieth R, 2001, AM J CLIN NUTR, V73, P288; Vieth R, 2004, J STEROID BIOCHEM, V89-90, P575, DOI 10.1016-j.jsbmb.2004.03.038; Vieth R, 2007, AM J CLIN NUTR, V85, P649; Viljakainen HT, 2006, J BONE MINER RES, V21, P836, DOI 10.1359-JBMR.060302; Weaver CM, 1999, J CLIN ENDOCR METAB, V84, P1839, DOI 10.1210-jc.84.6.183962545
Ausdruck und Verstehen in der musikalischen Improvisation als kokreativer Fluktualisierung – Perspektiven Integrativer Musiktherapie
No full textIn der vorliegenden Arbeit wird der Frage nach Ausdruck und Verstehen, nach ko-kreativer Hermeneutik und dem Gewinn von „vitaler Evidenz“ verstanden als „leibliches Erleben, emotionale Erfahrung und kognitive/rationale Einsicht in intersubjektiver Bezogenheit“ in therapeutischen Prozessen, besonders in den integrativen Kreativtherapien wie der Integrativen Musiktherapie usw., aber auch in der Integrativen Therapie insgesamt nachgegangen. Vor dem Hintergrund kreativitätstheoretischer und systemtheoretischer Überlegungen wird anhand exemplarischer Beispiele gezeigt, dass Phänomene und Strukturen sich verflüssigen, fluktualisieren durch Improvisationen in Sprache und in der Musik. Durch solche improvisatorische Flexibilisierungen, bei gleichzeitiger Gewährleistung hinlänglicher Stabilität können sich Verhaltensmuster/Strukturen durch kreative Therapieformen nachhaltig verändern. In ko-kreativen Prozessen intersubjektiver Hermeneutik werden Phänomene des sprachlichen und nichtsprachlichen Ausdrucks vermittelt und ausgelegt.In the present work, the question of expression and understanding, of co-creative hermeneutics and the gain of “vital evidence” understood as “physical perceiving, emotional experience and cognitive/rational insight wihin intersubjective relation” is addressed in therapeutic processes, especially in the integrative creative therapies as Integrative Music therapy etc., but also in integrative therapy as a whole. Against the background of creativity theory and system theory considerations, exemplary examples show that phenomena and structures are liquefied and fluctuated through improvisations in language and music. Such improvisational flexibilizations, while at the same time ensuring adequate stability, can solidly change behavior patterns/structures through creative forms of therapy . This means that behavioral patterns can change through creative forms of therapy. In co-creative processes of intersubjective hermeneutics, phenomena of verbal and non-verbal expressiona are conveyed and interpreted.https://www.fpi-publikation.de/polyloge/26-2021-vieth-fleischauer-h-petzold-h-g-1999-ausdruck-und-verstehen-in-der-musikalischen-i-m-p-r-o-v-i-s-a-t-i-o-n-als-kokreativer-fluktualisierung-perspektiven-integrativer-musikth/peerReviewedpublishedVersio
Epithalamivm Qvo Virvm Praenobilissimvm Ervditissimvm Amplissium Do. Ioannem Henricvm Stvss Paedagogii Illvstris Ilfeldensis Prorectorem Meritorivm Mvltitvdine Celebratissimvm Cvm Desponata Virgine ... Anna Catharina VViniker Goettingae Die XXV. Julii A. R. S. MDCCXXIIII. ... Pie Precati Laetabvndi Prose Qvvntvr Omnes Litteris Et Hvmanitati Operantes In Paedagogio Illvstri Ilfeldensi
No full textHochzeitsgedicht auf Johann Heinrich Stuss, Prorektor, und Anna Katharina Winiker, 25. Juli 1724[Mit diesen Gedichten solte ... aufwarten Ivlivs Avgvstvs Vieth Hannoveranvs]Autopsie nach Exemplar der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Northvsae Litteris Coeleriani
Argumentative Grundlagen einer Bindung der Anwendung prädikativer Gentests an Gesundheitszwecke
No full textVieth A. Argumentative Grundlagen einer Bindung der Anwendung prädikativer Gentests an Gesundheitszwecke. In: Tillmann H, Kirsten M, Gerlind R, Miriam V, eds. Schöne - gesunde - neue Welt? : das humangenetische Wissen und seine Anwendung aus philosophischer, soziologischer und historischer Perspektive. Bielefeld: Univ. Bielefeld; 2002: 1-11
The Offer of Advanced Imaging Techniques Leads to Higher Acceptance Rates for Screening Colonoscopy : a Prospective Study
No full textBACKGROUND:
Colonoscopy plays a fundamental role in early diagnosis and management of colorectal cancer and requires public and professional acceptance to ensure the ongoing success of screening programs. The aim of the study was to prospectively assess whether patient acceptance rates to undergo screening colonoscopy could be improved by the offer of advanced imaging techniques.
MATERIALS AND METHODS:
Overall, 372 randomly selected patients were prospectively included. A standardized questionnaire was developed that inquired of the patients their knowledge regarding advanced imaging techniques. Second, several media campaigns and information events were organized reporting about advanced imaging techniques, followed by repeated evaluation. After one year the evaluation ended.
RESULTS:
At baseline, 64% of the patients declared that they had no knowledge about new endoscopic methods. After twelve months the overall grade of information increased significantly from 14% at baseline to 34%. The percentage of patients who decided to undergo colonoscopy because of the offer of new imaging methods also increased significantly from 12% at baseline to 42% after 12 months.
CONCLUSIONS:
Patients were highly interested in the offer of advanced imaging techniques. Knowledge about these techniques could relatively easy be provided using local media campaigns. The offer of advanced imaging techniques leads to higher acceptance rates for screening colonoscopies
DIASTEREOFACIAL SELECTIVITY IN THE ALDOL REACTIONS OF CHIRAL ALPHA-METHYL ALDEHYDES - A COMPUTER MODELING APPROACH
No full textTransition state modelling of the aldol reaction of Z enol borinates with chiral alpha-methyl aldehydes (see Schemes 4 and 6) suggests that three transition structures (F, AF, R) play a dominant role in controlling pi-facial selectivity. The "Felkin" structure (F) is characterized by Me-CH --- C(O)-C* and CH---C(O)-C*-Me dihedral angles of about -60-degrees/-65-degrees and +100-degrees. The "Roush" structure (R) has values of -60-degrees/-65-degrees and +/-175-degrees/180-degrees, while the "Anti-Felkin" one (AF) has values of +60-degrees/+65-degrees and about +50-degrees. Our analysis suggests that nonbonded interactions play the most important role in determining aldehyde diastereofacial selectivity in the reactions with Z enolates, and that stereoelectronic effects are possibly overridden by steric effects. Reactions with aldehydes bearing relatively small and "flat" substituents (Ph-, H2C=CH-, Me2C=CH-) are 3,4-syn selective ("Felkin" selective) while reactions with aldehydes bearing bulkier groups (various alkyls) are 3,4-anti selective ("Anti-Felkin" selective) (see Tables 1 and 2). This result is essentially due to destabilization of both (F) and (R) structures. In particular, in order to relieve strain-energy structure (F) opens the CH---C(O)-C*-Me dihedral angle from +60-degrees to ca. +100-degrees. In this way the bulky substituents (alkyls) are pushed towards the aldehyde hydrogen. In the (AF) structure the CH---C(O)-C*-Me dihedral angle is around +50-degrees and the [aldehyde hydrogen - alkyl] interaction disappears. Enolate aggregation and chelation effects in the case of lithium enolates can possibly explain discrepancies observed between lithium and boron enolates and between the experimental ratios and the force field-predicted ratios
There is no lower threshold level for parathyroid hormone as 25-hydroxyvitamin D concentrations increase
No full text[No abstract available]2
Child Abuse and the Church: A Call for Prevention, Treatment, and Training
No full text Child abuse is both a sin and a crime. In this article, we present a call to the global Christian church to prevent and treat child abuse, and to train professionals across disciplines to do so. Vieth discusses effective child protection policies in churches. Among other recommendations, he encourages consultation with child protection experts, thorough screening of child workers, and accountable supervision of children in church. Tchvidjian examines cultural aspects of missions organizations that contribute to the abuse of children in the mission field. He suggests that missions organizations who have failed to protect abused children in the past placed their reputation above child protection, failed to treasure children, and believed in God-sanctioned power and control of missions workers. Knodel reviews the efforts of Christian organizations to prevent the trafficking of children worldwide. She finds effective advocacy occurring across the globe but among Christian organizations that are rarely tied to any specific denominational support. Next, Walker reviews evidence-based treatment recommendations for children and adolescents. Trauma-focused CBT is a leading empirically supported treatment for child abuse. Recently, efforts have been made to sensitively integrate faith into TF-CBT. Vieth then discusses effective church responses to allegations of abuse. He suggests suspending the activities of a church worker when allegations are made against him or her in addition to informing the police. Tchivdjian concludes by discussing the mission and vision of the GRACE foundation—a multidisciplinary Christian nonprofit organization dedicated to protecting children from child abuse and treating children who have been abused. </jats:p
- …
