1,721,046 research outputs found
Early molecular defects in human insulin resistance: studies in healthy subjects with low insulin sensitivity
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The effect of short-term triiodothyronine administration on thyroxine response to exogenous TSH in man.
No full textIn order to examine whether thyroid hormone concentration interfere with the thyroid gland responsivity to TSH, paired studies on the effect of short-term T3 treatment on T4 response to exogenous TSH ( 5 I.U. i.m.) were carried out in 10 euthyroid volunteers. During T3 administration ( 120 mcg/day for 4 days starting 48 hr before TSH injection) a significant decrease in T4 concentrations was observed both prior to and after TSH, with an inhibition of the T4 response ranging from 36-77% as calculated from the area under the response curve. The present data are in agreement with the existence of a "short-loop" thyroid-thyroid regulatory mechanism in man. In fact, the decreased percent rise of T4 after TSH suggests an inhibitory effect of T4 release following TSH, even though a modification of T4 kinetic parameters during T3 administration may account for a portion of the lowering of T4 blood concentrations
A reduced Glut 4 content in adipose tissue is not an early defect in the development of human insulin resistance
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Effect of metformin on insulin binding to receptors in cultured human lymphocytes and cancer cells.
No full textPhenformin has opposite effects on insulin and growth hormone binding to IM-9 lymphocytes
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