3,607 research outputs found
LONG-TERM SAFETY OF A DUAL REGIMEN OF RALTEGRAVIR AND RITONAVIR-BOOSTED PROTEASE INHIBITOR IN ARV-EXPERIENCED PATIENTS WITH CHRONIC KIDNEY DISEASE
No full textObjective: to evaluate the long-term safety of a dual regimen of raltegravir (RAL) and ritonavir-boosted protease inhibitor (PI/r) in ARV experienced patients with chronic kidney disease (CKD)
Methods: prospective, single centre, study in patients on treatment with 2NRTI + PI/r who switched to RAL and PI/r because of CKD. Demographic, epidemiological, laboratory, viro-immunological data were collected using medical report database. Patients were required to have undetectable viral load at baseline and during the previous 12 months. CKD was defined on the basis of National Kidney Foundation Guidelines (2002).
Results: 8 patients were included: 7/1 male, median age 50 years. At baseline all patients had HIV RNA <40 copies/ml and median CD4 540 cells/mmc. 4/8 were receiving TDF/FTC as backbone and 4/8 ABC/3TC; 3/8 showed severe CKD (stage 4), and 5/8 moderate CKD (stage 3). Patients switched from 2NRTI to RAL maintaining the same PI/r (5 LPV/r, 2 DRV/r, 1 ATZ/r). After a median follow-up of 19 months all patients were on treatment. At the latest visit, median CD4 was 661/mmc, HIV RNA was below 40 copies/ml in all patients. 4/8 patients had a mild CKD (Stage 2), 3/8 moderate CKD (stage 3) and 1/8 maintained severe CKD (stage 4). No other clinical or laboratory adverse events were observed.
Conclusion: Our data suggest that dual regimen of RAL and PI/r could be an attractive and safe options in patients with chronic kidney disease. Limitation of this study is the low number of patients included. Further randomized clinical trials are needed in order to confirm the efficacy and safety of this strategy
A Convex Mirror. Schopenhauer's Philosophy and the Sciences
No full textSchopenhauer is most recognizable as "the philosopher of pessimism," the author of a system that teaches how art and morality can help human beings navigate life in "the worst of all possible worlds." This dominant image of Schopenhauer has cut off an important branch of his tree of philosophy: the metaphysics of nature and its dialogue with the sciences of the time.
A Convex Mirror sheds new light on the development of Schopenhauer's philosophy and his ongoing engagement with the natural sciences. Understanding Schopenhauer's metaphysics requires both an insight into his relationship with science and an appreciation of the role of the natural sciences in his philosophical project. In the first edition of The World as Will and Representation (1819), Schopenhauer dealt with science within the framework of Kant and Schelling's philosophies of nature, but his growing perplexity with them led him to an original, more complex conception of the relationship between science and metaphysics. He therefore embarked on a revision of his metaphysics of nature, which ultimately affected its core concepts—namely, the will and ideas—and influenced his decision to publish a volume of Supplements (1844) rather than a revised edition of his main work.
The evolving relationship of Schopenhauer's philosophy to the natural sciences is a powerful interpretative tool: a "convex diffusing mirror" that reflects the totality and complexity of his system and sheds light on the core concepts of his philosophy, such as the systematic structure of his philosophy, reality and representation, idealism and realism, the polysemic nature of ideas, and the will as the thing in itself
THE IMPACT OF HIGHLY EFFECTIVE ANTIRETROVIRAL THERAPY ON PREVALENCE OF AIDS AND NON-AIDS-DEFINING CANCERS IN PEOPLE LIVING WITH HIV ATTENDING THE HIV/AIDS DIVISION OF FERRARA HOSPITAL
No full textP145 New challenges in the long-term management of people living with HIV (PLWH): introduction of patient-reported outcomes (PROs) into routine clinical practice. A pilot study
No full textAs HIV disease has evolved from a life-threatening to a chronic condition, attention has shifted to the long-term health of PLWH. In this context, the use of PROs and Patient-Reported Outcome Measures (PROMs) becomes essential to understand patient’ perceptions and improve understanding of their overall well-being
La complessità della conservazione dei materiali di storia e d’arte. È possibile una nuova cultura che, nel XV della morte di Giovanni Urbani, ne riprenda le proposte disperse per sviluppare la "rivoluzione copernicana" che vi era implicita?
No full textUna "Fedra" di Jon Fosse
No full textIl dramma di Jon Fosse è una versione della Phèdre di Racine, riformulata in neo-norvegese e in versi liberi molto vicini alla lingua colloquiale, nello stile minimalista tipico di questo scrittore, dove rima, allitterazione, assonanza e ripetizione conferiscono al testo una qualità musicale e una dimensione arcaica. Il presente articolo intende evidenziare gli elementi stilistici e compositivi che fanno della Fedra di Fosse una tragedia contemporanea sui rapporti familiari. L’uso ripetuto di pause e silenzi allude al non detto e all’indicibile dell’esperienza umana, alla mostruosità e all’ambiguità dei ruoli familiari.
Jon Fosse’s play is a version of Racine’s Phèdre rephrased in New Norwegian and in a free verse close to everyday language in the author’s habitual minimalistic style to which rhyme, allitteration, assonance and repetitions confer musical quality and an archaic distance. The present article aims at showing through which stylistic and compositive devices Fosse succeeds in making Phedra’s tragedy into a contemporary tragedy about family relationships. Through repeated pauses and silences, the author tries to convey the unsaid or the unspeakable about human experience, about the monstruosity and the ambiguity of family roles
Raltegravir plus a boosted protease inhibitor: experience in patients with resistance and/or NRTI-re-lated adverse events
No full textObjectives
: to evaluate the efficacy and safety of a dual therapy of
raltegravir (RAL) and ritonavir-boosted protease inhibitor (PIr) in
patients with resistance and/or NRTI-related adverse events.
Methods Cohort of HIV infected adults starting a dual therapy with
RAL plus PIr from Jan 2008 to Sep 2009 in 3 Italian HIV reference
centres. Patients changing ARV for resistance and/or NRTI-related
adverse events were included. Demografic, epidemiological, labora-
tory and immunological-virological data were collected using medical
report database 60
Infection 38 · 2010 · Supplement I
ICAR
2010
– Posters
Results
: 24 triple class-experienced patients were included: male 79%,
median age 49 years, median baseline CD4 346/mmc, 83% of the pa-
tients had HIV RNA below 40 copies/ml. HIV genotipic resistance
test were available in 18/24 patients: all of them showed a complete
resistance to NRTI drugs. At baseline 19 patients were receiving 2
NRTI+ PI/r, 4 2NRTI+NNRTI. Reasons for change of the previous
regimen were virologic failure (n=4), liver toxicity (n=3), renal failure
(n=3), cardiovascular events (n=2), simplification (n=12). Patients
started therapy with RAL + DRV/r (n=18), TPV/r (n=2), LPV/r (n=2),
ATV/r (n=2).
After a median follow-up of 48 weeks, treatment interruption oc-
curred in 1 patient lost to follow-up. At the latest visit, median CD4
was 421/mmc and HIV RNA was below 40 copies/ml in all patients.
No adverse events were observed, hepatic and renal function has been
improved in patients with previous observed failure.
Conclusion
: In this antiretroviral-experienced population a dual ther-
apy of RAL + PI/r seems an attractive regimen in patients with resis-
tance and/or NRTI-related adverse events. Limitation of this study is
the low number of patients included. Further randomized clinical tri-
als are needed in order to confirm the efficacy and safety of this strat-
eg
Development and transferability of grape EST-SSR markers suitable for mapping in Vitis spp.
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