1,291 research outputs found
Weak-Type Inequality for Conjugate First Order Riesz-Laguerre Transforms
No full textIn this paper we introduce a conjugate class of Riesz transforms in the context of Laguerre polynomials. We prove their weak-type (1,1) and Lp, 1Fil: Forzani, Liliana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; ArgentinaFil: Sasso, E.. Università degli Studi di Genova; ItaliaFil: Scotto, Roberto Aníbal. Universidad Nacional del Litoral; Argentin
AIME DONIAT CHANTE VINCENT SCOTTO / Aimé DONIAT, avec accompagnement d'orchestre
No full textComprend : CAROLINE, CAROLINE / BENECH - V. TELLY et Vincent SCOTTO - PESCADORE... ADDIO L'AMORE / J. RODOR et Vincent SCOTTO - LE PLUS BEAU TANGO DU MONDE / R. SARVIL et Vincent SCOTTO - TANT QU'IL Y AURA DES ETOILES / André HORNEZ - H. VENDRESSE et Vincent SCOTTO - L'AMOUR EST UNE ETOILE / René SARVIL et Vincent SCOTTO - CHANSON POUR NINA / Géo KOGER et Vincent SCOTTO - ALASKA / L. LEMARCHAND - DECAYE - CAROL et Vincent SCOTTO - ADIEU, VENISE PROVENCALE / René SARVIL et Vincent SCOTTO - VIENI... VIENI / Géo KOGER - Henri VARNA et Vincent SCOTTO - LAISSEZ-MOI VOUS AIMER / René PUJOL - AUDIFFRED - Géo KOGER et Vincent SCOTTO - CELLE QUE J'AIME EST PARMI VOUS / J. RODOR - J. BERTET et Vincent SCOTTO - COQUIN D'AMOUR / Jean BOYER et Vincent SCOTTO - LES BAISERS / P. CARTOUX - J. RODOR et Vincent SCOTTO - UN PETIT CABANON / René SARVIL et Vincent SCOTTOBnF-Partenariats, Collection sonore - BelieveContient une table des matière
A Spiritual Reaction to Islamic Prosperity: The Power of Sorrow in Riccoldo da Monte di Croce’s "Letters to the Triumphant Church"
No full textThis chapter tackles the argumentative strategies behind Riccoldo da Monte di Croce's "Epistole ad Ecclesiam Triumphantem" written in the aftermath of the Mamluk conquest of Saint John of Acre (1291), the last outpost of the Christian Kingdom of Jerusalem. I will linger on how the threatening presence of Muslims in the East allowed Riccoldo to develop a creative meditation on faith, a refined theological and rhetorical manifesto providing the author and his Christian readers with a spiritual shelter from the dramatic events taking place on earth. I am going to examine in particular Riccoldo’s experience of "sorrow"—one of the possible translations of the Latin word "tristicia"— by looking specifically at the ways in which he describes his faith in God. I will show how, on a rhetorical level, Riccoldo’s exegesis of the Book of Job through Gregory the Great turns out to be the exhortative backbone of the whole collection of his imaginary letters. Referring to Job, it has been claimed that the "Epistole" bear witness to the author’s spiritual crisis, particularly to his crisis of faith, as well as to his loss of certainty and hope in God’s plan—this implies an interpretation of the Book of Job in a deterministic, literalist and pessimistic fashion. I aim to challenge this interpretation of the "Epistole" as a desperate lament conceived by an author who finds himself incapable of escaping a fatalistic view of the present, realistically confused regarding God’s salvation plan and even suffering from agnosticism. I will demonstrate that by means of careful exegetical and rhetorical strategies, the "Epistole" instead provide substantial evidence of Riccoldo’s very faith vis-à-vis the general crisis surrounding him, shedding light on his expectations about the reaction of the Dominican Order—and the Western Church on a broader level—to the last stage of Islamic expansion
An update on recent developments in the search for hepatitis C virus therapies with pan-genotypic efficacy
No full textBourdillon (F.), Lombrail (P.), Antoni (M.), Benrekassa (J.), Bennegadi (R.), Leloup (M.), Huraux-Rendu (C.), Scotto (J.C.). La santé des populations d'origine étrangère en France
No full textCharbit Yves. Bourdillon (F.), Lombrail (P.), Antoni (M.), Benrekassa (J.), Bennegadi (R.), Leloup (M.), Huraux-Rendu (C.), Scotto (J.C.). La santé des populations d'origine étrangère en France. In: Revue européenne des migrations internationales, vol. 6, n°3,1990. p. 163
MOLECULAR BASIS OF MYOSIN VI ALTERNATIVE SPLICING IN CELLULAR TRANSFORMATION
No full textMolecular basis of myosin VI alternative splicing in cellular transformation
Rossella Scotto Di Perrotolo1, Carlos Niño1 and Simona Polo1,2
1IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy.
2DIPO, Dipartimento di Oncologia ed Emato-Oncologia, Universita’ degli Studi di Milano, Via
Festa del Perdono 7, 20122 Milan, Italy.
Alternative splicing is a finely regulated process that plays a role in cancer development through largely unknown molecular mechanisms. Our lab characterized an alternatively-spliced exon cassette, called large insert, in the actin motor protein myosin VI. The inclusion of the large insert generates a long isoform involved in endocytosis, while the skipping produces a short isoform involved in cell migration. This finding is relevant to ovarian cancer where exon skipping dictates addiction to myosin VI short for tumor cell migration.
Aim of this thesis was to understand how the isoform choice is regulated.
We have set up convenient 2D and 3D epithelial cell culture models to modulate isoforms expression and to characterize the molecular mechanism behind. Our study identified a signaling pathway involved in the AS-reprogramming during the conversion from an epithelial/static to a mesenchymal/motile phenotype and three splicing regulators contributing to the myosin VI AS decision that appears to be promising therapeutic targets for ovarian cancer treatment
ALIBERT CHANTE SA PROVENCE / ALIBERT avec SELLERS et son Jazz Marseillais
No full textTitre uniforme : [Un de la Canebière]. ExtraitTitre uniforme : [Trois de la marine]. Extr.Titre uniforme : [Au pays du soleil]. Extr.Titre uniforme : [Adieu ! Venise provençale]Comprend : ADIEU... VENISE PROVENCALE : de l'opérette "Arènes Joyeuses" / (Vincent) SCOTTO - Livret : H. ALIBERT - Lyrics : R. SARVIL - COMME UN MOUCHOIR DE POCHE / ANONYME ; avec Gaby SIMS - J'AIME LA MER COMME UNE FEMME : de l'opérette "Un de la Canebière" / Vincent SCOTTO - Livret : H. ALIBERT - Lyrics ; R. SARVIL - YOUPI ou LA VALSE DU RASCATI : de l'opérette "Les GANGSTERS du Château d'If" / V. SCOTTO et R. SARVIL - A PETITS PAS : de l'opérette "Au pays du Soleil" / V. SCOTTO et R. SARVIL ; avec Jenny HELIA - LE PETIT BAL DE LA BELLE DE MAI : de l'opérette "Les Gauchos de Marseille" / V. SCOTTO et R. SARVIL ; avec Mireille BARD - SUR LE PLANCHER DES VACHES : de l'opérette "Trois de la Marine" / V. SCOTTO et R. SARVIL - CANE... CANE... CANEBIERE - LES PESCADOUS... OUH !... OUH ! - LE PLUS BEAU TANGO DU MONDE / avec Gaby SIMS - VOUS AVEZ L'ECLAT DE LA ROSE / Vincent SCOTTO - LivretH. ALIBERT - Lyrics : R. SARVIL / avec Gaby SIMS - MIETTE de l'opérette "Au Pays du Soleil" / Vincent SCOTTO - R. SARVIL ; avec Jenny HELIA - LE PLAISIR DE LA PECHE : de l'opérette "Les Gangsters du Château d'If" / Vincent SCOTTO et R. SARVIL - L'AMOUR EST ENFANT DU MIDI / Ch. HUMEL et P. LORISEBnF-Partenariats, Collection sonore - BelieveContient une table des matière
Is a phenylalanine-glucosamine derivative able to affect the main responsible for IκB protein phosphorylation?
No full textNuclear factor κB (NFkB) is an ubiquitous transcription factor well known for its role in the innate immune response. In fact, it is involved as activator of inflammatory mediators such as cytokines. It consists of subunit dimers including p65, RelB, c-Rel, p50 and p52. Under normal conditions, they are bound in the cytosol by an inhibitory protein known as inhibitor of NFkB (IkB). The responsible for IkB phosphorylation is IkB kinase (IKK) complex, consisting of two catalytic subunits (IKKα and IKKβ) and a regulatory one. When activated, IKK phosphorylates IkB, thus tagging it for proteasomal degradation and freeing the NFkB subunit dimers which translocate to the nucleus and bind to specific DNA sequences within the promoter region of vast array of genes. Previous in vivo and in vitro studies in our laboratory demonstrate that Glucosamine (GlcN) and its N-acetyl phenylalanine derivative (NAPA) are able to counteract effects induced by inflammatory cytokines, particularly modulating some genes, under the control of NFkB, upregulated by TNF-α. So, the aim of this study is to better understand whether these two molecules may affect the activity of IKKα and IKKβ through some specific interactions.
HTB-94, treated respectively with TNF-α and single molecules, are grown, lysated, incubated with anti-IKKα antibody and eventually treated with magnetic beads. This assay is performed to immunoprecipitate the activated IKK complex. Subsequently, an in vitro kinase assay is performed using a recombinant protein as substrate while in presence and absence of both molecules, to analyze the immunoprecipitated complex (IP-IKK). An immunocytochemistry is performed to visualize if IKKα re-localization is affected by GlcN and NAPA.
Owing to immunoprecipitated complex formation, molecules can directly interact with kinases because they don’t need to cross cell membrane. In presence of GlcN, IP-IKK can phosphorylate the recombinant substrate, whileas in presence of NAPA 0.5mM the phosphorylation is inhibited. Further studies are performed evaluating IKK inhibition activity by GlcN and NAPA on recombinant protein using recombinant IKKα and IKKβ molecules. As previously observed, NAPA strongly inhibits IKKα activity on itself and on the recombinant substrate, but no effect is observed on IKKβ. On the contrary, GlcN cannot inhibit either IKKα or IKKβ at any concentrations used. In immunocytochemistry IKKα is mainly cytoplasmic in untreated cells, but it accumulates in nucleus under TNF-α stimulus. Pre-treatment with both molecules shows a mainly cytoplasmic IKKα localization.
In conclusion, it is observed that both molecules affect IKKα localization, but only NAPA is an effective IkB phosphorylation inhibitor explaining how both molecules modulate expression level gene under NFkB control.
Scotto d'Abusco A; Politi A; Giordano C; Scandurra R ̧
Arthritis Research & Therapy 2010; doi: 10.1186/ar2920
Traiano e Ponticelli (napoli) -Il recupero della autoespressione-Il lavoro di quartiere nel rione traiano .
No full textTalvolta per imparare a progettare bisogna conoscere da vicino i bisogni e i desideri della gente "impigliata "soprattutto nelle periferie urbane,luogo di stridenti contradizioni.I bambini sono il segnale più evidente della contradizione città-gente e per questo vanno osservati con attenzione e rispetto.L'Architettura può far molto se si esprime in modo partecipativo e creativo,aprendo ampi varchi alle nuove generazioni.Il gesto,il disegno sono i primi modi didattici e di ricerca collettiva
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