2,927 research outputs found
Analysis of Manpower System with Alert Human Resource Personnel
No full textAbstract Manpower planning is concerned with matching the supply of people with the jobs available in any organization. Every year, during the months of appraisal, organizations record high rates of employee turnover. Due to various reasons, manpower employed leave the system periodically. Loss of manpower also occurs due to dismissal and death of employees. This loss of manpower has to be compensated by suitable recruitment. But, recruitment cannot be made frequently since it involves cost. Also recruitment of new employees and giving them 4028 S. Mythili, R. Ramanarayanan and S. Srinivasa Raghavan training to suit the needs of the organization works out to be costlier than retaining the available employees. Hence the Human Resource Department has to be alert and avoid manpower loss due to resignations. There is a maximum amount of loss of man power that can be permitted in the organization which is called the threshold beyond which the manpower system of the organization reaches a point of break down. In this paper we introduce the concept of Human Resource Department alertness and find the joint Laplace Stieltjes transform of time to recruit (T) and recruitment time (R). Mathematics Subject Classification: 90B0
Molecular basis of late-life globoid cell leukodystrophy
No full textGloboid cell leukodystrophy is an autosomal recessive inherited disease caused by deficiency of the lysosomal enzyme galactocerebrosidase (GALC). Although the severe, rapidly progressing infantile form is the most common, late-onset forms have been described. We investigated the molecular basis of GALC deficiency in a patient with a late-life mild form of globoid cell leukodystrophy who survived into the eighth decade. Since material suitable for mutation analysis was no longer available from the proband, her GALC genotype was reconstructed by analyzing this gene in her six obligate carrier offspring. One allele contained the mutation 809G>A (G270D) in the 1637C background, while the other allele contained three sequence variants: 1609G>A (G537R), 1873G>A (A625T), and 1650T>A (V550V) in the 1637T background. These mutations were confirmed in the proband's genomic DNA isolated from a sural nerve biopsy. Expression studies indicated that the G537R is a disease-causing mutation, as it resulted in no GALC activity, either alone or together with the A625T. This A625T sequence variant did not affect the enzyme activity, at least when expressed in the 1637T background. The mild clinical phenotype was likely to be associated with the 809G>A, since residual GALC activity, about 17% of the control activity, was detected in the expression studies of this mutation. This mutation has been found in several other patients with late-onset GLD
Multiple mutations in the galactocerebrosidase gene are associated with a very mild late-onset form of Globoid cell leukodystrophy
No full textSurface-modified nanoerythrosomes for potential optical imaging diagnostics
No full textNanoerythrosomes (NERs), vesicle-like nanoparticles derived from red blood cells, represent a new and interesting vector for therapeutic molecules and imaging probes, mainly thanks to their high stability and excellent biocompatibility. Aiming to present a proof-of-concept of the use of NERs as diagnostic tools for in vitro/in vivo imaging purposes, we report here several functionalization routes to decorate the surfaces of NERs derived from bovine blood with two different fluorophores: 7-amino-4-methylcumarin and dibenzocyclooctinecyanine5.5. Notably, the fluorophores were cross-linked to the NERs surface with glutaraldehyde and, in the case of dibenzocyclooctinecyanine5.5, also using a click-chemistry route, termed strain-promoted azide-alkyne cycloaddition. The physicochemical characterization highlighted the high stability of the NERs derivatives in physiological conditions. Furthermore, the loading efficiency of the fluorophores on the NERs surface was evaluated using both UV–Vis spectroscopy and fluorescence microscopy
Lifetime and g-factor results for the 13 2 - 1985 keV level in 91Nb and the 15 2 - 2288 keV level in 91Zr
No full text- …
