63 research outputs found
Response to commentary on a trial comparing krill oil versus fish oil
No full textAbstract
Nichols et al. (Lipids Health Dis 13:2, 2014) raised concern about the higher n-6 concentration in fish oil used in our recent study which is different from typical commercial fish oils (Ramprasath et al. Lipids Health Dis 12:178, 2013). The aim of our study was to compare the effect of consumption of similar amount of n-3 PUFA from krill and fish oil with placebo on plasma and RBC fatty acids. As the concentration of n-3 PUFA in the fish oil utilised was higher than that in krill oil, we deemed it important to keep consistent the concentration of n-3 PUFA and volumes to be administered to participants between krill versus fish oils. As such, the fish oil used in the study was diluted with corn oil. Although the n-6 PUFA concentration in fish oil was higher compared to traditionally used fish oil, consumption of the fish oil used in our study actually reduced the total n-6 PUFA in plasma and RBC to a similar extent as did krill oil. Overall, our conclusion was that the increases in plasma and RBC concentrations of EPA and DHA along with improvement in the omega-3 index observed with consumption of krill oil compared with fish oil are due to differences in absorption and bioavailability based on the structural difference of the two oils rather than their n-6 PUFA content.Peer Reviewe
(2018-2019) Impact of Glycemic status (HbA1c) and Mean Platelet volume on Vascular complications in Diabetics
No full textA Study of Non-Invasive Prediction of Large Oesophageal Varices in Chronic Liver Disease patients in Tertiary Care Hospital
No full textINTRODUCTION:
Portal hypertension is a major hallmark of cirrhosis which can be defined as a portal pressure gradient exceeding 5-10 mm Hg. In portal hypertension, portosystemic collaterals decompress the portal circulation and give rise to varices. In patients with cirrhosis and portal hypertension, esophageal varices and gastrointestinal bleeding represents a serious complications leading to mortality. 40% of the patients with compensated disease and 60% of the patients with decompensated disease had esophageal varices at diagnosis.
AIMS AND OBJECTIVES:
1. To study the incidence of large and small esophageal varices in patients with liver disease.
2. To evaluate various clinical, biochemical and ultrasonographic parameters in predicting the presence of large esophageal varices.
3. To evaluate the sensitivity and specificity of each of the parameters in predicting large esophageal varices.
MATERIALS AND METHODS:
Patients:
Consecutive newly diagnosed patients with liver disease (cirrhosis / portal hypertension) with or without history of gastrointestinal bleeding at our institution (Institute of Internal Medicine, Rajiv Gandhi Government General Hospital, Chennai) which serves as a tertiary referral center were included in this prospective study. Patients were asked to sign an informed consent prior to enrollment in the study.
Inclusion criteria:
◈ Age: 18 years to 80 years.
◈ Liver disease with portal hypertension.
Exclusion criteria:
◈ Hepatocellular carcinoma detected by USG.
◈ Primary hematologic disorders.
◈ Current treatment with beta blockers/ nitrate.
◈ Previous surgical intervention for portal hypertension.
Clinical Evaluation:
All patients underwent a detailed clinical evaluation at entry. Relevant history, etiology of liver disease (alcohol intake, blood transfusion etc.,), and signs of liver cell failure such as alopecia, anemia, jaundice, parotid swelling, gynaecomastia, testicular atrophy, palmar erythema, pedal edema, ascites, splenomegaly were recorded.
By ultrasonography of abdomen, mild ascites were noted. Moderate and massive ascites were detected clinically by shifting dullness and fluid thrill. According to West Havens Criteria, encephalopathy were noted.
CONCLUSION:
1. The prevalence of large esophageal varices in our study was found to be 49.15%
2. Our study shows that low platelet count, splenomegaly, portal vein and splenic vein size are independent predictors.
3. Use of these parameters help identify patients to perform endoscope for patients only with a high risk of large esophageal varices.
4. These parameters help in avoiding unnecessary endoscopies.
5. This may help reduce costs which will be economical.
6. If its efficacy is confirmed, it may permit institution of prophylactic measures like beta-adrenergic antagonists for preventing primary variceal bleeding in patients with liver cirrhosis, without the need for costly and invasive investigations like gastrointestinal endoscopy
Particle swarm and simulated annealing based intuitive search optimization of flexural behaviors in bioparticles impregnated coir fiber–vinyl ester composites
No full textBeneficial role of silibinin in monitoring the cadmium induced hepatotoxicity in Albino Wistar rats
No full textCadmium (Cd), an environmental toxic pollutant affects many organs in human beings specially the liver and kidney. In this study, Cd (3 mg/kg body weight (b.w.)) was subcutaneously administered to rats for 3 weeks, which shows significantly (
Optimization of impact behavior of bio particulated coir-vinyl ester composites using simulated annealing with post analysis
No full text380-385<span style="font-size:9.0pt;mso-bidi-font-size:
12.0pt;mso-bidi-font-family:" times="" new="" roman""="" lang="EN-GB">The present investigation is
focused on evaluation and optimization of impact behavior of bio particulated
coir-vinyl ester composites. The bio particles such as groundnut
shell, alumina and termite mound soil have been selected and their
influences on the impact behavior of coir -vinyl ester composites are
evaluated. The bio particulated composite fabrications are planned as per full
factorial design with the different levels of fibre length, fibre content and
particulate content.
The impact strength of fabricated composites is evaluated. The nonlinear
regression models are developed for the prediction of impact behaviors over the
specified range of conditions. The fabrication parameters for the maximum value
of impact behaviors are also determined using simulated annealing algorithm and
conformance checking is carried out using post analysis. The optimum values of
impact behaviors of 39.5, 45.9 and 52.1 kJ/m2 are obtained in
coir-vinyl ester composites reinforced with groundnut shell, alumina and
termite mound soil respectively.
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Protective role of silibinin in cadmium induced changes of acetylcholinesterase, ATPases and oxidative stress in brain of albino wistar rats
No full textCadmium (Cd) a highly toxic metal is considered to be a multitarget toxicant, principally its accumulates in the liver, kidney and hardly get into the brain parenchyma by the brain-barrier system. In this study, Cd (3 mg/kg body weight (b. w.)) was subcutaneously administered to rats for 3 weeks, which shows significantly (
Arthrodiastasis in the management of stiff hip
No full textArthrodiastasis (using external fixator and distraction) has been used for various pathologies including deformity correction/stiff hip/slipped capital femoral epiphysis. Historically this has been used for treatment of Perthes disease. The purpose of our study is to evaluate efficacy of arthrodiastasis in management of stiff hip. A 15 year old boy with stiff hip presented with complaints of pain in the left hip for past 6 months. Radiologically the left proximal femur was found to be deformed with metaphyseal widening, sclerosis and arthritic changes. Hip spanning external fixator using limb reconstruction system was done. Distraction was done at a rate of 1 mm/day. After 2 months, fixator was removed. Hip was mobilized under anaesthesia. Good range of all movements was achieved. Arthrodiastasis seems to be a good option in young adolescent in whom total hip replacement needs to be delayed as much as possible
Topics in statistical finance
No full textThis thesis is divided into three parts. The first part investigates the presence of long term dependence in stock price data via a permutation test based on the correlation structure of the underlying stock prices. These tests reveal the short term nature of stock price dependence structure. The second part extends
Ramprasath and Singh(2007)'s `statistical options' to define a group of American type options based on robust estimators of location. The payoff functions of these path dependent options are based on a new set of stochastic processes which are defined using various robust estimators of location. The asymptotic distributional behavior of these new processes is ascertained which in turn is used in pricing
the options. Markov Chain Monte Carlo (MCMC) methods were used to compute the prices of the statistical options. The third part explores a stock price model parameter estimation problem and interprets a growth rate parameter.Ph.D.Includes bibliographical references (p. 81-83)
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