1,721,033 research outputs found
CRITICAL SURVEY COVERING THE YEAR 2004 : INTRODUCTION AND TRANSFORMATION OF FUNCTIONAL GROUPS
No full textThe following journals have been abstracted:
Acc. Chem. Res. 2004, 37 ;
Angew .Chem. int. Ed. 2004, 43
Bioorg. Med. Chem. Lett. 2004, 14
Bioorg. Med. Chem. 2004, 12
Chem. Commun. 2004
Chem. Rev. 2004, 104
Chem. Soc. Rev. 2004, 33
Chem. Eur-J. 2004, 10
Dalton Trans. 2004
Eur .J. Org. Chem. 2004
Green Chem. 2004, 6
J. Am. Chem. Soc. 2004, 126
J. Comb. Chem. 2004, 6
J. Med. Chem. 2004, 47
J. Org. Chem. 2004, 69
Nano Lett. 2004, 2
Org. Biomol. Chem. 2004, 2
Org. Lett. 2004, 6
Organimetalllics 2004, 23
Synlett 2004
Synthesis 2004
Tetrahedron, 2004, 60
Tetrahedron Letters 2004, 45
Tetrahedron Asymmetry 2004, 15
This report collects selected synthetic methods, published in the above listed journals, concerning the introduction and the transformation of functional groups
A ROLE FOR CHEMISTRY IN CELL BIOLOGY AND MEDICINE
No full textChemical biology has emerged as a new scientific discipline to change the way scientists approach and study the interface between chemistry, biology and physics. This report is a selection of papers appeared in the year 2004, on journals belonging to the bio-medical area. The authors have reviewed those papers where the contribution of chemists, and in particular of organic chemists, is wide and important. The aim of this review is to highlight some interesting subjects and to consider what skills chemists are requested to operate, in the field of cell biology and medicine
2-OXAZOLIDINONES AS REGIOSELECTIVE PROTECTION OF BETA-AMINO ALCOHOLS IN THE SYNTHESIS OF 2-AMINO-1-ARYL-3-FLUORO-1-PROPANOLS
No full textEnantio-differentiating catalytic oxidation by a biomimetic trinuclear copper complex containing L-histidine residues
No full textThe trinuclear complex [Cu3PHI]6+, derived from a ligand containing two chiral L-histidine residues, performs the catalytic oxidation of L- and D-Dopa with remarkable enantio-differentiation; this depends on the anchoring effect provided by the copper center which is not participating in the catalytic reaction and recognizes the chirality of the substrate
ASYMMETRIC-SYNTHESIS OF BETA-HYDROXY-ALPHA-AMINO ACIDS BY CONDENSATION OF ALIPHATIC AND AROMATIC-ALDEHYDES WITH ZINC(II) AND COPPER(II) COMPLEXES OF (1R)-3-HYDROXYMETHYLENE BORNAN-2-ONE GLYCINE IMINES
No full textThe stereochemical outcome of the condensation reactions of aliphatic and aromatic aldehydes with the metal complexes 1 is strongly dependent on the nature of the metal ion. The copper(II) complex la only affords threo-P-hydroxy-cr-amino acids with fairly good enantiomeric excesses when reacting with aromatic aldehydes. The zinc(II) complex Ib gives a mixture of three and erythro diastereoisomers with a predominance of the erythro forms in the case of aromatic aldehydes
Synthesis of novel derivatives of resveratrol and screening for potential cancer chemopreventive activities
No full textResveratrol (trans-3,4’,5-trihydroxystilbene) has attracted the attention of the biomedical researchers because of its beneficial physiological effects it produces. Positive effects of resveratrol has been observed in the field of cardiovascular diseases and neurodegenerative disorders. It has been also identified as a potent cancer chemopreventive agent in assays representing the three major stages of carcinogenesis (i.e. tumor initiation, promotion and progression). We have synthesized a variety of Resveratrol analogues by chemical modification of the parent trihydroxy stilbene skeleton. The compounds were screened for cancer chemopreventive potential using a series of bioassays relevant for the prevention of carcinogenesis in humans (inhibition of cytochrome P450 1A; determination of NAD(P)H:quinone reductase activity; scavenging of radicals; inhibition of cyclooxygenase activity; inhibition of NO synthase; antiestrogenic and estrogenic activity)
ASYMMETRIC-SYNTHESIS OF DIETHYL ALPHA-AMINO-ALPHA-ALKYL-PHOSPHONATES BY ALKYLATION OF THE CHIRAL SCHIFF-BASE DERIVED FROM (+)-KETOPINIC ACID AND DIETHYLAMINOMETHYL PHOSPHONATE
No full textThe alkylation of the chiral Schiff base derived from the condensation of (+)-ketopinic acid and diethyl aminomethylphosphonate followed by hydrolysis affords diethyl (S)-alpha-amino-alpha-alkyl phosphonates with high enantiomeric excesses when benzyl or allyl halides are used in the alkylation step. An improved procedure for the preparation of diethyl aminomethylphosphonate is also reported
Auxiliary chiral effects in asymmetric alkylation of phosphonoglycine equivalents: study by semiempirical modeling methods
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