162 research outputs found
Helicobacter pylori ノカンセンケイロトテイチャクニカカワルリスクインシノツイキュウ
No full textHamada, M., Nomura, R., Ogaya, Y. et al. Potential involvement of Helicobacter pylori from oral specimens in overweight body-mass index. Sci Rep 9, 4845 (2019). https://doi.org/10.1038/s41598-019-41166-5Kadota T, Hamada M, Nomura R, Ogaya Y, Okawa R, Uzawa N, Nakano K. Distribution of Helicobacter pylori and Periodontopathic Bacterial Species in the Oral Cavity. Biomedicines. 2020; 8(6):161. https://doi.org/10.3390/biomedicines8060161Nomura, R., Kadota, T., Ogaya, Y. et al. Contribution of Streptococcus mutans to Helicobacter pylori colonisation in oral cavity and gastric tissue. Sci Rep 10, 12540 (2020). https://doi.org/10.1038/s41598-020-69368-
Physiological and antioxidant responses of Quercus ilex to drought in two different seasons
No full textRe: Can dehydrated human amnion/chorion membrane accelerate the return to potency after a nerve-sparing robotic-assisted radical prostatectomy? Propensity score-matched analysis
No full textThe objective of this study is to determine if the use of dehydrated human amnion/chorion membrane (dHACM) allograft wrapped around the NVB during a robotic-assisted radical prostatectomy (RARP) accelerates the return to potency. 940 patients with preoperative SHIM >20 underwent RARP with some degree of bilateral NS. Of these, 235 patients underwent RARP, with bilateral placement of dHACM graft around the NVBs. They were matched in a 1:3 proportion with a similar group of patients (n = 705) who did not receive the allograft (control group or group 2). Minimum follow-up was 12 months. Postoperative outcomes were analyzed between propensity-matched dHACM graft (group 1) and non-graft groups (group 2). Kaplan–Meier survival curves were compared across techniques using the log-rank test. There were no significant demographic differences between the two groups. Potency was defined as the ability to achieve and maintain satisfactory erections firm enough for sexual intercourse, with or without the use of PDE-5 inhibitors. The mean time to potency was significantly lower in group 1 (2.37 months) versus group 2 (3.94 months) (p < 0.0001). The potency recovery rates were superior for group 1 at all early time points measured except at 12 months. The time to potency was significantly shorter in the dHACM group with full NS, 2.19 ± 1.84 versus 2.78 ± 2.70 mo. in the non-dHACM with full NS (p = 0.029). In the dHACM group with partial NS, the mean time to potency was 3.05 ± 2.32 versus 3.92 ± 3.42 mo. in the non-dHACM with partial NS (p = 0.021). Patients who received the dHACM wrap around the NVB after RARP accelerates the return to potency when compared to a similar control group without the use of the allograft. We also demonstrated that this faster return to potency occurs regardless of the degree of the NS preservation. Younger patients (<55 years of age) had the highest overall advantage if they received the graft. Our results indicate that dHACM placement at the site of the prostatic NVB does not increase the risk of BCR after RARP, neither in the presence of PSM, extra-prostatic disease (≥pT3) nor high Gleason score (Gleason ≥8)
Joint interpretation of magnetotelluric, seismic, and well-log data in Hontomín (Spain)
No full textAcknowledgements. This work is dedicated to the memory of Andrés Pérez-Estaún, brilliant scientist, colleague, and friend. The authors sincerely thank Ian Ferguson and an anonymous reviewer for their useful comments on the manuscript. Xènia Ogaya is currently supported in the Dublin Institute for Advanced Studies by a Science Foundation Ireland grant IRECCSEM (SFI grant 12/IP/1313). Juan Alcalde is funded by NERC grant NE/M007251/1, on interpretational uncertainty. Juanjo Ledo, Pilar Queralt and Alex Marcuello thank Ministerio de Economía y Competitividad and EU Feder Funds through grant CGL2014- 54118-C2-1-R. Funding for this Project has been partially provided by the Spanish Ministry of Industry, Tourism and Trade, through the CIUDEN-CSIC-Inst. Jaume Almera agreement (ALM-09-027: Characterization, Development and Validation of Seismic Techniques applied to CO2 Geological Storage Sites), the CIUDEN-Fundació Bosch i Gimpera agreement (ALM-09-009 Development and Adaptation of Electromagnetic techniques: Characterisation of Storage Sites) and the project PIERCO2 (Progress In Electromagnetic Research for CO2 geological reservoirs CGL2009-07604). The CIUDEN project is co-financed by the European Union through the Technological Development Plant of Compostilla OXYCFB300 Project (European Energy Programme for Recovery).Peer reviewe
THE USE OF SCAFFOLDING TISSUE BIOGRAFTS TO BOLSTER THE VESICOURETHRAL ANASTOMOSIS DURING SALVAGE ROBOT-ASSISTED RADICAL PROSTATECTOMY REDUCES LEAK RATES AND CATHETER TIMES
No full textTHE USE OF SCAFFOLDING TISSUE BIOGRAFTS TO BOLSTER THE VESICOURETHRAL ANASTOMOSIS DURING SALVAGE ROBOT-ASSISTED RADICAL PROSTATECTOMY REDUCES LEAK RATES AND CATHETER TIME
SALVAGE ROBOTIC-ASSISTED LAPAROSCOPIC PROSTATECTOMY (SRARP)
No full textINTRODUCTION & OBJECTIVES: There is a significant cohort of patients who experience recurrent prostate cancer after primary ablative
therapy. Salvage robot assisted radical prostatectomy (sRARP) represents a feasible treatment option in these cases. The purpose of the
study is to examine the functional and biochemical outcomes in a large series of sRARP performed by a single surgeon (VRP).
MATERIAL & METHODS: We retrospectively reviewed our database of more than 6,500 patients who have undergone RARP. Over a
period of 8 years (2008-2015) we identified 65 patients who have had sRARP following different types of primary ablative treatment failure.
The Kaplan-Meier method was used to estimate survival. Both univariate and multivariate regression analysis were used to determine
predictors of biochemical recurrence.
RESULTS: The median interval from primary therapy to sRARP was 48 (range 26-85) months. The median age of patients undergoing
sRARP was 69 (65-73) years. The 11 (16.9%) patients had positive surgical margins, 14 (21.6%) – extraprostatic extension and 16 (24.6%)
seminal vesicle invasion (pT3b). There were no cases of rectal injury or any intraoperative complications. 16 (25%) patients had a
biochemical failure after a median follow-up of 16.5 (6-56) months and 10 (15%) required adjuvant hormone therapy. 85% of patients that
had sRALP were free of additional therapy at a median of 16.5 months. All 65 patients were continent prior to salvage RARP and 34
(52.3%) of them reported full continence after surgery (no pad used). The 29 (44.6%) of them partial continence1-2 pads and 5 (3.1%)≥ 3
pads, respectively. 19 (29.2%) patients were considered potent before sRARP and 9 (47.4%) of them retained potency after the sRARP.
Tumour stage pT3b (seminal vesicle invasion), pre-op Gleason >7, and positive surgical margins were predictive of biochemical recurrence.
CONCLUSIONS: Our series supports the feasibility of sRARP as a suitable treatment option for patients who have experienced local
recurrence of prostate cancer. Our outcomes for biochemical recurrence, potency, and continence are reasonable, maintaining a
reasonable balance between cancer control data, quality of life issues and risk of complications. Longer follow-up will be necessary in
determining the full extent of sRARP in providing adequate cancer control and quality of life issue
Reduced tree health and seedling production in fragmented Fagus sylvatica forest patches in the Montseny Mountains (NE Spain)
No full textHabitat fragmentation results in smaller and more isolated populations that may be at higher risk of extirpation or further decline in comparison with their more continuously distributed progenitors. Risks to fragmented populations have frequently been considered from the perspective of population genet- ics, however, disruption of normal plant demography may be an equal or greater threat to population persistence. We compared demographic performance and tree health in continuous and fragmented forest plots with similar tree size structure and local climatic and physiographic conditions in order to determine if fragments are characterized by poor health and reproduction. We found that beech forest fragments showed lower seedling density, more tree crown damage and also higher percentage of dead trees. However, mortality of juveniles in the youngest age class was substantially lower in fragments such that long-term population structure remained similar between the two forest types. If reduced mortality compensates for reduced seedling establishment, as our data suggest, then fragmented pop- ulations should show greater long-term persistence than would be predicted based on comparison of young age cohorts alone. However, despite such demographic compensation, the decreased health of adult trees may pose an increasing future threat to the fragmented populations. Our results demonstrate the importance of integrating demographic patterns over long time periods and not relying on single year or cohort comparisons and may partly explain population genetic differences previously reported for the same populations
Summer season and long-term drought increase the richness of bacteria and fungi in the foliar phyllosphere of Quercus ilex in a mixed Mediterranean forest
No full textWe explored the changes in richness, diversity and evenness of epiphytic (on the leaf surface) and endophytic (within leaf tissues) bacteria and fungi in the foliar phyllosphere of Quercus ilex, the dominant tree species of Mediterranean forests. Bacteria and fungi were assessed during ontogenic development of the leaves, from the wet spring to the dry summer season in control plots and in plots subjected to drought conditions mimicking those projected for future decades. Our aim was to monitor succession in microbiota during the colonisation of plant leaves and its response to climate change. Ontogeny and seasonality exerted a strong influence on richness and diversity of the microbial phyllosphere community, which decreased in summer in the whole leaf and increased in summer in the epiphytic phyllosphere. Drought precluded the decrease in whole leaf phyllosphere diversity and increased the rise in the epiphytic phyllosphere. Both whole leaf bacterial and fungal richness decreased with the decrease in physiological activity and productivity of the summer season in control trees. As expected, the richness of epiphytic bacteria and fungi increased in summer after increasing time of colonisation. Under summer dry conditions, there was a positive relationship between TRF (terminal restriction fragments) richness and drought, both for whole leaf and epiphytic phyllosphere, and especially for fungal communities. These results demonstrate that changes in climate are likely to significantly alter microbial abundance and composition of the phyllosphere. Given the diverse functions and large number of phyllospheric microbes, the potential functional implications of such community shifts warrant exploration
Safety of Live Robotic Surgery: Results from a Single Institution
No full textBackground: Live surgery events (LSEs) have become one of the most attended activities at surgical meetings and provide a unique opportunity for the audience to observe the decision-making process used by skilled and experienced surgeons in real time. However, there is an ongoing discussion on whether patients treated during LSE are at higher risk of complications. Objective: To examine LSE outcomes for robot-assisted radical prostatectomy (RARP) and establish patient safety and efficacy. Design, setting, and participants: From January 2008 to April 2016, >9000 patients underwent RARP at our institution, performed by a single surgeon. From this group, 36 patients underwent live RARP surgery (LS group) transmitted via video link from our institution to an external congress. A control group was obtained from our database to compare outcomes between the LS group and patients undergoing RARP under regular circumstances. The data were prospectively collected in a customized database and retrospectively analyzed. Intervention: All patients underwent RARP performed by a single surgeon at our institution. Outcome measurements and statistical analysis: Postoperative outcomes were compared between the LS (n = 36) and the control (n = 108) groups using Student's t test and analysis of variance for continuous variables, and a two-tailed Fisher's exact test for categorical variables. Statistical significance was set at p <. 0.05. Results and limitations: There were no significant differences in baseline characteristics (age, body mass index, comorbidities, preoperative Gleason score, Sexual Health Inventory for Men score and American Urological Association symptom score) between the groups. The median console time was shorter for the LS group (73. min, interquartile range [IQR] 70-79) than for the control group (78. min, IQR 75-87; p = 0.0371). No major complications were reported in either group, and only four minor complications were observed in the control group (p = 0.2415). After median follow-up of 31 mo (IQR 18-50), only one patient (2.77%) in the LS group experienced biochemical recurrence, compared to four (3.71%) in the control group (p = 0.7927). There was no significant difference in continence rates between the LS and control groups (97.22% vs 93.52%; p = 0.7768). No differences in potency rate were evident by the end of the follow-up period (LS 69.44%, control group 70.37%; p = 0.8432). The retrospective nature, the lack of randomization, and the single-institution experience are limitations of the study. Conclusions: In this series of live transmitted RARPs, perioperative results (oncological and functional outcomes and complications) were similar to those found in daily practice. After careful patient selection, LSEs are safe with minimal patient morbidity in the hands of an experienced surgeon working with a familiar surgical team. Further evaluation of the results from other surgeons at other centers is necessary. Patient summary: We investigated the safety of surgeries broadcast live from our institution. We found that outcomes were similar to those for patients undergoing surgery under regular circumstances in terms of the rate of complications and oncological and functional outcomes. We conclude that live transmitted surgery is safe in well-selected patients in the hands of an experienced surgeon. We evaluated the safety of live robot-assisted radical prostatectomy by analyzing live transmitted surgeries performed in our institution. The perioperative results (oncological and functional outcomes and complications) were similar to those found in daily practice
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