300 research outputs found
Il gioco delle antifrasi nell’incipit della Fiaccola sotto il moggio
No full textThe textual incipit of the second Abruzzo tragedy by Gabriele d’Annunzio, La fiaccola sotto il moggio (1905), defines its character in close relationship with three literary references: the Vangeli (of Luca, Matteo and Marco), the Coefore of Eschilo and La figlia di Iorio (1903; ed. 1904) by the poet himself. The analysis of the first portion of the dramaturgical text shows how, starting from the initial atmospheres, the author loves the game of antiphrastic references with those works, which constitute the filigree of the poetic construction through thematic and conceptual references. Above all, the inverse morality that animates Gigliola, the protagonist, emerges in relation with the evangelical premises contained in the title, as well as the subversion of the tragic order of the classical matrix which also inspires the text
Shortening velocity and myosin and myofibrillar ATPase activity related to myosin isoenzyme composition during postnatal development in rat myocardium
No full textThe relation between functional properties of the contractile apparatus, such as shortening velocity and ATPase activity, and myosin isoenzyme composition was studied in ventricular myocardium of adult (60-90-day-old) rats and of newborn (3-day-old) and young (10- and 20-day-old) rats. In adult animals, variations of isomyosin pattern were produced by reducing food intake and by changing the thyroid state. Hyperthyroidism was induced with triiodothyronine daily injection for 15 days; hypothyroidism was induced with iodine-free diet and KClO4 in drinking water for 50-60 days. The following parameters were studied: 1) calcium-magnesium-activated and magnesium-activated ATPase activity of washed and purified myofibrils, 2) calcium-activated ATPase activity of purified myosin, 3) isomyosin composition and relative content of alpha-myosin heavy chains (alpha-MHCs), and 4) force-velocity curve of left and right ventricle papillary muscles. To take into account the difference in excitation-contraction coupling between newborn and adult myocardium, the determination of the force-velocity curve was repeated in Krebs' solution with normal [CaCl2] (2.5 mM) and in Krebs' solution with high [CaCl2] (10 mM). During postnatal growth, the relative content of alpha-MHC increased and reached a maximum at about 20 days. Pronounced increases of myofibrillar and myosin ATPase activity and in shortening velocity occurred during the same period. In adult hyperthyroid rats, alpha-MHC content as well as enzymatic activity and shortening velocity were higher than in control adult animals. Hypothyroidism and food deprivation caused a decrease of alpha-MHC content and a reduction of both enzymatic activities and shortening velocity. The study of the relations between alpha-MHC relative content and functional parameters showed that 1) in ventricular myocardium of adult rats a linear relation existed between alpha-MHC content and myosin and myofibrillar ATPase activity and shortening velocity, and 2) in newborn and young rat ventricular myocardium, both enzymatic activities and shortening velocity were lower than would have been expected on the basis of the linear relation described above. This latter observation could be accounted for by a variation in specific activity of myosin during postnatal development or by the presence of peculiar isomyosins that cannot be detected with usual electrophoretic techniques
Corrigendum to âResponse to: Mitochondrial neuropathy affects peripheral and cranial nerves and is primary or secondary or bothâ [Neuromuscular Disorders 26/8 (2016) 549](S0960896616302899)(10.1016/j.nmd.2016.06.007)
No full textThe authors regret that the order of the first and last names was listed incorrectly in the above letter. The correct order for the authors' names is: Michelangelo Mancuso, Daniele Orsucci, Corrado Angelini, Enrico Bertini, Claudio Bruno, Valerio Carelli, Giacomo P. Comi, Massimiliano Filosto, Costanza Lamperti, Maurizio Moggio, Tiziana Mongini, Isabella Moroni, Paola Tonin, Antonio Toscano, Gabriele Siciliano, on behalf of the Nation-wide Italian Collaborative Network of Mitochondrial Diseases. Moreover, as this was a letter, only the affiliation of the corresponding author (M. Mancuso) was given. The corresponding author's address is not the affiliation for all other authors except for Daniele Orsucci and Gabriele Siciliano who share the same affiliation: Department of Clinical and Experimental Medicine, Neurological Institute, University of Pisa, Pisa, Italy. The authors would like to apologise for any inconvenience caused
Circadian rhythms of acid secretion and electric parameters in rat gastric mucosa in vitro
No full textIn male Wistar rats standardized from birth in LD 12:12 conditions (with light from 0700 to 1900 hr), samples of mucosa from the body of the stomach were isolated in vitro and mounted in a Ussing-type chamber. Spontaneous secretion of the hydrogen ion (H+)during 45 min of incubation was measured. Some electric parameters [transmucosal potential difference (PD) and electrical resistance (R)] were detected in the gastric mucosa both during H+ secretion and during inhibition of acid secretion by cimetidine. The variables studied were analyzed with the single cosinor method, and all revealed a circadian rhythm with acrophases during the dark span. The higher values of PD and R found during the dark hours are unrelated to acid secretion and may indicate a greater efficiency of ionic pumps and a limited passive permeability
Polyneuropathy due to cobalamin deficiency in the rat
No full textIn the present study, we investigated the peripheral nervous system (PNS) (both in terms of its ultrastructure and in terms of its function) of rats made cobalamin (Cbl)-deficient either through total gastrectomy or through prolonged feeding on a Cbl-deficient diet. In both these types of Cbl-deficient neuropathies we found: (a) ultrastructurally, intramyelin and endoneural edema, with no or minimal axonal damage in the PNS, in dorsal root ganglia, and the ventral and dorsal rootlets of the spinal cord; (b) electrophysiologically, a significant reduction in the nerve conduction velocity, consistent with that reported in (a); (c) morphometrically, a significant reduction in the density of myelinated fibers both in the sciatic nerve and in the peroneal nerve. All these pathological changes were reversed by chronic postoperative administration of Cbl into totally gastrectomized (TGX)-rats, hinting at the specificity of the damage itself in relation to the permanent Cbl-deficient status of the TGX-rats. No signs of segmental demyelination or remyelination were found. We also observed a turning of type I fibers into type II fibers in the soleus muscle of all our Cbl-deficient rats, however the Cbl deficiency had been induced. This muscular change was still present in TGX- and Cbl-treated rats, and it cannot be related to a malnutrition status, since it has been observed also in rats fed a Cbl- deficient diet. All these results demonstrate that Cbl deficiency strongly affects rat PNS within different parameters
CT-guided radiofrequency ablation: a potential complementary therapy for patients with unresectable primary lung cancer--a preliminary report of 33 patients.
No full textOBJECTIVE. We report our preliminary evaluation of the effectiveness, safety, technical feasibility, and complications of palliative CT-guided radiofrequency ablation of unresectable primary pulmonary malignancies. SUBJECTS AND METHODS. Thirty-three patients (26 men and seven women; age range, 44-75 years; mean age, 66 years) with unresectable malignant lung neoplasms underwent 35 CT-guided tumor ablation sessions. Follow-up CT was performed 6 months (29 cases) and 1 year (10 cases) after treatment. In 19 patients, these findings were correlated with cytohistopathologic assessment obtained with CT-guided fine-needle aspiration biopsy or core biopsy at 6-month follow-up. Size and CT appearance of the treated lesions were correlated with cytohistologic features and clinical scores. RESULTS. Thirty-five technically successful radiofrequency ablation treatments were performed. The only complications in the periprocedural period were three cases of minor pneumothorax, five cases of sputum cruentum, and three asymptomatic pleural effusions. Contrast-enhanced CT performed at 6-month follow-up showed four cases of complete and 13 cases of partial lesion ablation, 11 cases of stabilized lesion size, and one case of increased lesion size. Contrast-enhanced CT performed at 1-year follow-up showed unchanged lesion size in six cases and reduction in four cases. Six-month cytohistologic examinations showed total coagulation necrosis in seven lesions and partial necrosis in 12. Clinical improvement in pretreatment symptoms was observed in 12 of 29 patients seen at 6-month follow-up. Eight patients died within 1 year of treatment of non-procedure-related causes. CONCLUSION. Our experience suggests that radiofrequency ablation can be used successfully in unresectable lung cancer as an alternative or complementary treatment to radio-or chemotherapy. Larger studies are necessary to fully evaluate its potential combination with other treatment techniques
R. Härtel, Die älteren Urkunden des Klosters Moggio, bis 1250 ; Wien : Verlag der Oesterreichischen Akademie der Wissenschaften, 1985 ; in-4°, 158 pages, planches [Oesterreichische Akademie der Wissenschaften. Publikationen des Historischen Instituts beim Oesterreichischen Kulturinstitut in Rom. II. Abteilung : Quellen ; 6. Reihe : Vorarbeiten zu einem Urkundenbuch des Patriarchats Aquileia, Bd 1].
No full textGuyotjeannin Olivier. R. Härtel, Die älteren Urkunden des Klosters Moggio, bis 1250 ; Wien : Verlag der Oesterreichischen Akademie der Wissenschaften, 1985 ; in-4°, 158 pages, planches [Oesterreichische Akademie der Wissenschaften. Publikationen des Historischen Instituts beim Oesterreichischen Kulturinstitut in Rom. II. Abteilung : Quellen ; 6. Reihe : Vorarbeiten zu einem Urkundenbuch des Patriarchats Aquileia, Bd 1].. In: Bibliothèque de l'école des chartes. 1987, tome 145, livraison 2. pp. 495-496
R. Härtel, Die älteren Urkunden des Klosters Moggio, bis 1250 ; Wien : Verlag der Oesterreichischen Akademie der Wissenschaften, 1985 ; in-4°, 158 pages, planches [Oesterreichische Akademie der Wissenschaften. Publikationen des Historischen Instituts beim Oesterreichischen Kulturinstitut in Rom. II. Abteilung : Quellen ; 6. Reihe : Vorarbeiten zu einem Urkundenbuch des Patriarchats Aquileia, Bd 1].
No full textGuyotjeannin Olivier. R. Härtel, Die älteren Urkunden des Klosters Moggio, bis 1250 ; Wien : Verlag der Oesterreichischen Akademie der Wissenschaften, 1985 ; in-4°, 158 pages, planches [Oesterreichische Akademie der Wissenschaften. Publikationen des Historischen Instituts beim Oesterreichischen Kulturinstitut in Rom. II. Abteilung : Quellen ; 6. Reihe : Vorarbeiten zu einem Urkundenbuch des Patriarchats Aquileia, Bd 1].. In: Bibliothèque de l'école des chartes. 1987, tome 145, livraison 2. pp. 495-496
Discordant HLA haplotype segregation in a family with progressive extrinsic ophthalmoplegia and ragged red fibres
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