38 research outputs found
Strangling technique to treat large cervicofacial venous malformations: A preliminary report
No full textBackground. Surgical removal of large cervicofacial venous malformations might be hampered by massive intraoperative bleeding. Moreover, these lesions often insinuate within normal surrounding tissue, making complete resection impossible without causing significant morbidity. Methods. Two patients affected by facial venous malformations nonresponsive to sclerotherapy underwent surgery. Bleeding and critical branching of the facial nerve within the lesion prevented the surgeons from proceeding with the removal. The unresectable malformation was decompressed by means of a number of nonresorbable stitches from the surface of the lesion to the periosteum, tailoring a permanent pressure dressing. Results. Outcomes at 12-month follow-up were stable, with good cosmetic results and satisfaction reported by both patients. No long-term side effects related to the procedure were observed. Conclusion. Decompression of large venous malformations by means of a strangling technique might represent a safe and effective procedure for those cases where a removal cannot be accomplished
Il ruolo dei farmaci antiangiogenetici nella gestione delle malformazioni artero-venose del distretto testa-collo
No full textLe malformazioni arterovenose (MAV) sono malformazioni ad alto flusso in cui una rete complessa di vasi mette in comunicazione diretta afferenze arteriose e drenaggio venoso. Le MAV vanno solitamente incontro a progressione nel corso della vita, mentre le regressioni spontanee documentate sono sostanzialmente eccezionali.
Le MAV sono estremamente aggressive e possiedono una capacità infiltrativa locale che ricorda quella delle neoplasie maligne. La resezione chirurgica “radicale” garantisce le più elevate possibilità di cura, ma non vi è unanimità sulla gestione delle MAV di dimensioni maggiori che non possono essere rimosse in modo completo.
Scopo di questa presentazione è quello di proporre un approccio differente al trattamento delle MAV di grosse dimensioni non candidabili alla resezione radicale.
L’associazione di farmaci antiangiogenetici (che deve iniziare prima della chirurgia e proseguire nel periodo postoperatorio) potrebbe avere un ruolo chiave nel prevenire la tanto temuta crescita “esplosiva” del nidus rimanente a fronte di un’asportazione parziale. Questo approccio potrebbe rendere possibile realizzare per questi pazienti recontouring e altre procedure più “orientate all’estetica”, con un ovvio miglioramento della qualità di vita.
Il più promettente tra i farmaci antiangiogenetici sembra essere la Talidomide, anche se altri farmaci come Sirolimus, inibitori della via di VEGF, interferoni e inibitori delle metalloproteinasi potrebbero rivelarsi altrettanto utili. Anche il propanololo potrebbe avere un ruolo simile, come sembrano indicare alcune recenti scoperte nel campo della retinopatia del prematuro e dell’oncobiologia
Complications After Treatment of Head and Neck Venous Malformations With Sodium Tetradecyl Sulfate Foam
No full textThe aim of this study was to evaluate complications in patients with head and neck venous malformations (VMs) treated with foam sclerotherapy using sodium tetradecyl sulfate (STS)
Occlusion of an intraosseous arteriovenous malformation with percutaneous injection of polymrthylmethacrylate
No full text
Sclerotherapy of peripheral vanous malformations: a new technique to prevent serious complications
No full textOcclusion of an intraosseous arteriovenous malformation with percutaneous injection of polymethylmethacrylate
No full textPrimary intraosseous arteriovenous malformations are rare. Many minimally invasive procedures can be considered preoperative steps and/or definitive treatment. The case reported regards a young woman with a voluminous arteriovenous extratroncular infiltrating malformation of the humerus. She underwent several treatments, but none of them was completely occlusive. The last treatment consisted of direct percutaneous puncture of the intraosseous alteration and injection of polymethylmethacrylate (PMMA), which is normally used in percutaneous vertebroplasty. We obtained complete occlusion of the humerus lytic lesion. To the best of our knowledge, this represents the first case of intraosseous AVM treated by percutaneous injection of PMMA
Genetic testing for vascular anomalies
No full textVascular anomalies (VAs) have phenotypic variability within the same entity, overlapping clinical features between different conditions, allelic and locus heterogeneity and the same disorder can be inherited in different ways. Most VAs are sporadic (paradominant inheritance or de novo somatic or germline mutations), but hereditary forms (autosomal dominant or recessive) have been described. This Utility Gene Test was developed on the basis of an analysis of the literature and existing diagnostic protocols. The genetic test is useful for confirming diagnosis, as well as for differential diagnosis, couple risk assessment and access to clinical trials
Diagnosis and treatment of venous malformations consensus document of the International Union of Phlebology (IUP)-2009
No full textConsensus Document of the International Union of Phlebology (IUP)-200
