63 research outputs found
Signum Vortumni Project. Il palinsesto architettonico a est degli Horrea Agrippiana. Un’analisi preliminare
No full textDuring the archeological excavations of Signum Vortumni Project (2016-2019) in the Horrea Agrippiana area there were being carry out survey and masonries's analysis at ground level of the complex situated at east of augustean warehouses. It deals with an unpublished architectural palimpsest that enriches the topographical framework of the site together with to data of recent excavations, regarding before Agrippa's warehouses. The acquisition and the analysis of those evidences gave back interesting novelties about the presence of a new domus late republican age B.C.) characterized by terraces on north-west low slopes of Palatine with a rich decorative elements. Obviously it belongs to a member of nobilitas senatorial. Those studies reveal that the domus has been disposed by brickwork's structures built befoure Horrea and dated to the first half of I B.C. New buildings, highlight in partial remains, allows to make some further reflections about Agrippa's complex and the making of the first Imperal Palaces on this side of Palatine
Development of a genetic algorithm for covariate analysis in population pharmacokinetic models
No full textTargeting Cancer Stem Cells: New Perspectives for a Cure to Cancer
No full textCancer stem cells (CSCs) are present in many solid tumors. Their signaling pathways and functions may be the key to developing new anticancer strategies against cancer. Several studies have linked the signaling pathways’ (e.g., Wnt, Notch, and Hedgehog pathways) aberrant activation to the development of numerous cancers. These signaling pathways hence provide attractive targets for further study toward new therapies. CSCs show several characteristics, such as self-renewal, differentiation, high tumorigenicity, and resistance to anticancer drugs. Drug resistance is the most useful in further evaluating the possibilities of reducing tumor mass or eliminating cancer by discovering new therapies. One of the key questions concerns the necessity of identifying superficial as well as intracellular markers, which are essential if the drug is to respond positively to CSCs. In recent years, CD133, CD44, ABCG2, and ALDH have been identified as biomarkers for certain forms of CSCs. However, recent studies have contributed to a better understanding of CSC-specific antigens; to date, there is no univocal characterization of antigens for CSCs. Our chapter aims to highlight the importance of identifying new markers to develop new therapeutic strategies against cancer
The sternum reconstruction: Present and future perspectives
No full textSternectomy is a procedure mainly used for removing tumor masses infiltrating the sternum or treating infections. Moreover, the removal of the sternum involves the additional challenge of performing a functional reconstruction. Fortunately, various approaches have been proposed for improving the operation and outcome of reconstruction, including allograft transplantation, using novel materials, and developing innovative surgical approaches, which promise to enhance the quality of life for the patient. This review will highlight the surgical approaches to sternum reconstruction and the new perspectives in the current literature
Un modello di calcolo delle criticità nei sistemi di drenaggio urbano
No full textAtti del II Convegno di idraulica urban
Combined use of tracer and ERT tests as effective tool for the investigation of heterogeneous alluvial aquifers
No full textThe presence of preferential groundwater transport was investigated in the heterogeneous alluvial aquifer of the upper Alento River, located in Campania (southern Italy), in a fluvial sector characterised by braided geomorphology and sedimentary deposition.
Groundwater tracing methods were applied by means of two-well tracer tests (natural and forced-gradient tracer tests) and the inflow of a fluorescent dyes detected by a mobile downhole fluorometer. Tracer concentrations monitored over the entire screened interval of the well (8 m long) and the breakthrough curves obtained at different depths highlight that the tracer appears only over a limited length of the screen interval. The results suggest that groundwater flow occurs trough alternative paths according to the complex geometrical and granulometric features of the underlying deposits, so that groundwater flow (direction and specific discharge) varies with depth.
These results have been confirmed by using of electrical resistivity tomography (ERT) that indicates, within alluvial deposits, the presence of two distinct electrostratigraphic horizons. The topmost superficial one, characterised by greater resistivity values, can be related to more coarse alluvial sediments with little finegrained
matrix and likely to more permeable materials. This evidence supports the thesis of a non-uniform groundwater flow within a high heterogeneous aquifer.
The results emphasise the usefulness of tracer tests and ERT as effective tools for the investigation of aquifer heterogeneity in studies concerning the fate of dissolved pollutants
Karst springs along the Murge Adriatic coastline (Apulia, southern Italy)
No full textApulia is an almost entirely karst region in southern Italy, being characterized by several thousand-meter-thick Mesozoic carbonate succession, diffusely outcropping in the Gargano (north), Murge (center) and Salento (south) areas.
It is surrounded by Adriatic and Ionian seas for most of its extent, with over 850 km of coasts and a significant, but not yet quantified, amount of freshwater gushing out along coastline or offshore. Mainly the coastal sectors of Apulian aquifers are then strongly exposed to seawater intrusion phenomena for both natural causes, due to the presence of fractures and karst forms, or human induced causes, such as sea level rise and over-exploitation.
Focusing on Murge area, the groundwater discharge to the sea typically occurs in a diffuse way, through groundwater fractures; locally it is concentrated where karst conduits reach the sea or coastal zones, that is where the hydraulic function of karst conduits for freshwater transfer prevails. Many thermal anomalies have been detected in the past thanks to multi-spectral aerial surveys (visible, infrared and thermal infrared), due to differences in temperatures between spring water and seawater.
In this work, we describe the Adriatic coast between the city of Monopoli and the Torre Canne place: in this area, the main known springs show average discharges ranging from 300-400 to 600 l/s, with maximum peaks slightly lower than 1.200 l/s. This is the coastal stretch where most of the thermal anomalies have been recognized as submarine springs. In addition, at several other locations, in the immediate proximity and along the coasts, there are proofs of water emergencies. To provide a contribution aimed at improving the knowledge about hydrogeology of this sector of Murge, we present new data on the karst coastal springs and a first attempt to link them with those coming out from the main inland recharge area
Note Illustrative della Carta Geologica d'Italia alla scala 1:50.000. F° 421 Ascoli Satriano
No full textAccurate classification of bioclimatic data: Temporal analysis
No full textThis paper presents a general methodology for processing bioclimatic data in the temporal domain. Two different methods are used to assess the presence of temporal trends in the time-series of bioclimatic indices at each measurement station. A preliminary stage checks for the statistical homogeneity in the data set and for the presence of serial autocorrelation in the data, applying the proper methods to remove these effects. The methodology has been applied to a case study in Apulia, Italy, using the popular De Martonne index as a bioclimatic indicator
Investigating dominant processes controlling the hillslope response in a Mediterranean Basin.
No full text- …
