17,350 research outputs found
Impaired neural development in a zebrafish model for lowe syndrome
No full textLowe syndrome, which is characterized by defects in the central nervous system, eyes and kidneys, is caused by mutation of the phosphoinositide 5-phosphatase OCRL1. The mechanisms by which loss of OCRL1 leads to the phenotypic manifestations of Lowe syndrome are currently unclear, in part, owing to the lack of an animal model that recapitulates the disease phenotype. Here, we describe a zebrafish model for Lowe syndrome using stable and transient suppression of OCRL1 expression. Deficiency of OCRL1, which is enriched in the brain, leads to neurological defects similar to those reported in Lowe syndrome patients, namely increased susceptibility to heat-induced seizures and cystic brain lesions. In OCRL1-deficient embryos, Akt signalling is reduced and there is both increased apoptosis and reduced proliferation, most strikingly in the neural tissue. Rescue experiments indicate that catalytic activity and binding to the vesicle coat protein clathrin are essential for OCRL1 function in these processes. Our results indicate a novel role for OCRL1 in neural development, and support a model whereby dysregulation of phosphoinositide metabolism and clathrin-mediated membrane traffic leads to the neurological symptoms of Lowe syndrome. © The Author 2011. Published by Oxford University Press. All rights reserved
Guidebook for Pre-conference North Island Field Trip A1 ‘Ashes to Issues’, 28-30 November, 2008
No full textWelcome to New Zealand or Aotearoa – „Land of the long lingering day [twilight]‟ – and to our three-day pre-conference North Island field trip „Ashes and Issues‟. We trust your stay in New Zealand is both informative and friendly and there is something for everyone on the trip. The itinerary in brief and a map of the North Island showing the main scientific stops are shown above. At the time of guidebook preparation, we have a group of 23, including four students, on the tour with participants from Japan, Taiwan, USA, UK, Australia and New Zealand. The tour leaders are Prof David Lowe (Univ. of Waikato, Hamilton) and Dr Haydon Jones (Scion Research, Rotorua). Assistant leader is Prof Paul McDaniel (Univ. of Idaho, Moscow), on leave at the Univ. of Waikato July-December, 2008. We offer a warm welcome to you all. Because we have considerable distances to travel (especially Day 3), as well as a range of stops planned, we will need to leave the hotel at 8.00 am each day
Sichuan (China), lakes on the saddle below mountains
No full textLakes on the Hai-Tze-Shan saddle below Djara Peak.Image is part of research condcuted by J. Hanson-Lowe for the article: Notes on the Pleistocene Glaciation of the South Chinese-Tibetan Borderland
Author(s): J. Hanson-Lowe
Source: Geographical Review, Vol. 37, No. 1 (Jan., 1947), pp. 70-87
Published by: American Geographical Society
Stable URL: http://www.jstor.org/stable/211362http://www.jstor.org/stable/211362Grayscal
Lowe, R, VX32343
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/400178Surname: LOWE. Given Name(s) or Initials: R. Military Service Number or Last Known Location: VX32343. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 38949.218449
Item: [2016.0049.32471] "Lowe, R, VX32343
Sichuan (China), hanging valleys formed by glaciers
No full textHanging valley on left-hand wall of valley below, and to east of the Sara La.Image is part of research condcuted by J. Hanson-Lowe for the article: Notes on the Pleistocene Glaciation of the South Chinese-Tibetan Borderland
Author(s): J. Hanson-Lowe
Source: Geographical Review, Vol. 37, No. 1 (Jan., 1947), pp. 70-87
Published by: American Geographical Society
Stable URL: http://www.jstor.org/stable/211362http://www.jstor.org/stable/211362Grayscal
Lowe, R C, 14757
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/400152Surname: LOWE. Given Name(s) or Initials: R C. Military Service Number or Last Known Location: 14757. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 52394.218423
Item: [2016.0049.32445] "Lowe, R C, 14757
Lowe, R C, TX5861
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/400174Surname: LOWE. Given Name(s) or Initials: R C. Military Service Number or Last Known Location: TX5861. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 31334.218445
Item: [2016.0049.32467] "Lowe, R C, TX5861
Sichuan (China), view of mountains across from Litang plain
No full textLooking across the Litang plain from somewhat east of that town. The "Lama's Hat" peak lies in the center of the picture and is flanked by corries.Image is part of research conducted by J. Hanson-Lowe for the article: Notes on the Pleistocene Glaciation of the South Chinese-Tibetan Borderland
Author(s): J. Hanson-Lowe
Source: Geographical Review, Vol. 37, No. 1 (Jan., 1947), pp. 70-87
Published by: American Geographical Society
Stable URL: http://www.jstor.org/stable/211362http://www.jstor.org/stable/211362Grayscal
Lowe, W R K, TX8257
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/400175Surname: LOWE. Given Name(s) or Initials: W R K. Military Service Number or Last Known Location: TX8257. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 31335.218446
Item: [2016.0049.32468] "Lowe, W R K, TX8257
Lowe, G R C, 419502
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/400156Surname: LOWE. Given Name(s) or Initials: G R C. Military Service Number or Last Known Location: 419502. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 56523.218427
Item: [2016.0049.32449] "Lowe, G R C, 419502
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