193 research outputs found
Novel glass fiber reinforced composites having a UV and peroxy curable fluoropolymer matrix
No full textProteomics in veterinary medicine: applications and trends in disease pathogenesis and diagnostics
No full textAdvancement in electrophoresis and mass spectrometry techniques along with the recent progresses in genomics, culminating in bovine and pig genome sequencing, widened the potential application of proteomics in the field of veterinary medicine. The aim of the present review is to provide an in-depth perspective about the application of proteomics to animal disease pathogenesis, as well as its utilization in veterinary diagnostics. After an overview on the various proteomic techniques that are currently applied to veterinary sciences, the article focuses on proteomic approaches to animal disease pathogenesis. Included as well are recent achievements in immunoproteomics (ie, the identifications through proteomic techniques of antigen involved in immune response) and histoproteomics (ie, the application of proteomics in tissue processed for immunohistochemistry). Finally, the article focuses on clinical proteomics (ie, the application of proteomics to the identification of new biomarkers of animal diseases)
Robot-assisted fenestration of giant hepatic cysts in posterosuperior segments
No full textBackgroundThe diffusion of the use of robotic surgical platforms, such as the da Vinci Xi Surgical System (R) (Intuitive Surgical, Sunnyvale, CA, USA), has been advocated by several authors to overcome the limitations of laparoscopy in hepatobiliary surgery.MethodsWe reported our experience of robot-assisted fenestration of giant hepatic cysts in posterosuperior segments with the use of indocyanine green fluorescence imaging. We described step by step our surgical technique including the operative room set-up, port placement and robotic instruments.ResultsWe enrolled 11 patients: nine females and two males with a mean age of 65 years (range 52-80 yrs). All procedures were undertaken successfully without intraoperative or postoperative complications. The mean surgical operating time was 125 min. The mean blood loss was 30 ml. The median postoperative stay was two days (range, 1 to 3 days).ConclusionsThe most significant advantage of the robotic approach was the ability to access hepatic cysts close to the diaphragm
An FDD Auxiliary Receiver with a Highly Linear Low Noise Amplifier
No full textAn auxiliary receiver is proposed, including a high dynamic range low-noise amplifier and second-order baseband filter to improve the compression point with low power dissipation. The receiver has high input impedance and it can be placed at the transmitter output without loading effects. Implemented in a 28nm CMOS technology it occupies an active area of 0.5 mm(2). The receiver has a measured NF of 6 dB and it can withstand up to +7 dBm continuous waveform (CW) signal at 80 MHz offset with less than 1-dB gain compression. The signal path and the clock generation circuits consume 27 mW and 20 mW at 2 GHz respectively
Preparation and properties of poly(urethane-urea) crosslinked coatings from perfluorocopolyethers and polyfunctional isocyanurates
No full textPlatelets from a patient heterozygous for the defect of P2(CYC) receptors for ADP have a secretion defect despite normal thromboxane A(2) production and normal granule stores - Further evidence that some cases of platelet 'primary secretion defect' are heterozygous for a defect of P2(CYC) receptors
No full textLow plasma levels of vitamin B-6 are independently associated with a heightened risk of deep-vein thrombosis
No full textBackground - Elevated plasma levels of total homocysteine (tHcy) before and after an oral methionine load (PML) are associated with an elevated risk of deep-vein thrombosis (DVT). We investigated whether plasma levels of B vitamins that are involved in Hcy metabolism are associated with an elevated risk of DVT. Methods and Results - We compared 397 cases with previous DVT with 585 matched healthy controls. The plasma levels of folate, vitamin B12, vitamin B6, and fasting and PML tHcy were measured. The ORs for DVT associated with high (>95th percentile) fasting levels and PML increases of tHcy were 2.1 (95% CI, 1.2 to 3.4) and 2.4 (95% CI, 1.5 to 3.9) after adjustment for established risk factors for DVT. Fasting plasma levels and PML increases in tHcy correlated negatively with vitamin levels. The crude OR for folate levels in the lowest quartile compared with the highest was 1.5 (95% CI, 1.1 to 2.1), and that for B6 levels in the lowest and second quartiles compared with the highest was 1.5 (95% CI, 1.0 to 2.1). However, after adjustment for established risk factors and fasting and PML tHcy, the ORs for B6 levels in the lowest and second quartiles only remained statistically significant (lowest quartile: OR, 1.8; 95% CI, 1.2 to 2.8; second quartile, OR, 1.9; 95% CI, 1.3 to 2.9). Conclusions - High fasting and PML tHcy and low vitamin B6 plasma levels are associated with an elevated risk for DVT independently of established risk factors for DVT. The association of low vitamin B6 levels with the risk for DVT is independent of fasting and PML tHcy levels
Evaluation of the PFA-100 (R) system in the diagnosis and therapeutic monitoring of patients with von Willebrand disease
No full textWe have evaluated platelet function at high shear with the PFA-100® system in different subtypes of von Willebrand disease (vWD), before and after the intravenous infusions of desmopressin or a factorVIII/von Willebrand factor (vWF) concentrate. Closure times with the PFA-100® system were determined for both the collagen/ADP and the collagen/epinephrine cartridges in 52 patients with vWD (9 type 1 'platelet normal', 5 type 1 'platelet-discordant', 8 type 1 'platelet-low', 6 type 2A, 9 type 2B, 6 type 2M Vicenza, 6 type 3 and 3 acquired vWD) and 40 controls. Measurements were repeated 1 and 4 h after the i.v. infusion of desmopressin (0.3 μg/Kg) in 26 patients with types 1, type 2M Vicenza or type 2A vWD, or of a factorVIII/vWF concentrate (Alphanate HT, 60 U/Kg) in 4 patients with type 3 vWD. At all time points, vWF plasma levels and the bleeding time (Symplate II) were also determined. Baseline closure times were longer in vWD patients than in controls with both the collagen/ADP and the collagen/ epinephrine cartridges. The sensitivity of the PFA-100® system (88% and 87% with the two cartridges) was higher than that of the bleeding time (65%). Treatment with desmopressin normalized the closure times in patients with type 1 'platelet-normal' or type 2M Vicenza vWD, had no significant effects in patients with type 1 'platelet-low', type 1 'platelet-discordant' or type 2A vWD. Infusion of a factorVII/vWF concentrate in patients with type 3 vWD slightly shortened their prolonged closure rimes, In general changes in PFA-100® were paralleled by shortenings of the bleeding times and increases in plasma vWF levels. The PFA-100® test reflects vWF-dependent platelet function under high shear stress and could be useful in the diagnosis and therapeutic monitoring of patients with vWD
Is the oral methionine loading test insensitive to the remethylation pathway of homocysteine?
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