42 research outputs found
A genetic structure of the early immigrants (Mukkalathor) of Tamil Nadu as inferred from autosomal loci
No full textGenomic affinity based on eight human - specific polymorphic insertion/ deletion loci was studied in an early immigrant population, Thevar group, of Tamil Nadu, South India. They are traditionally agriculturists, culturally homogenous and endogamous. The seven Alu elements (Alu APO, Alu CD4, Alu PV92, Alu FXIIIB, Alu ACE, Alu PLAT, Alu D1) and one nuclear insertion of mitochondrial DNA segment (mtNUC) were analyzed for all the DNA samples. All these loci showed high levels of polymorphism in caste populations of Tamil Nadu, thereby reflecting their common ancestry. The significant greater inter-individual variation and the moderate population differentiation probably indicate genetic closeness of these populations. The present study populations were also compared with six other caste populations of Tamil Nadu for which the data were available. Phylogenetic analysis of these populations broadly corresponds to their known ethno-historical affinities
A genetic structure of the early immigrants (Mukkalathor) of Tamil Nadu as inferred from autosomal loci
No full textGenomic affinity based on eight human - specific polymorphic insertion/ deletion loci was studied in an early immigrant population, Thevar group, of Tamil Nadu, South India. They are traditionally agriculturists, culturally homogenous and endogamous. The seven Alu elements (Alu APO, Alu CD4, Alu PV92, Alu FXIIIB, Alu ACE, Alu PLAT, Alu D1) and one nuclear insertion of mitochondrial DNA segment (mtNUC) were analyzed for all the DNA samples. All these loci showed high levels of polymorphism in caste populations of Tamil Nadu, thereby reflecting their common ancestry. The significant greater inter-individual variation and the moderate population differentiation probably indicate genetic closeness of these populations. The present study populations were also compared with six other caste populations of Tamil Nadu for which the data were available. Phylogenetic analysis of these populations broadly corresponds to their known ethno-historical affinities
Recommended from our members
Optimizing cross-dock operations under uncertainty
No full texttextCross-docking is an important transportation logistics strategy in supply chain management which reduces transportation costs, inventory holding costs, order-picking costs and response time. Careful planning is needed for successful cross-dock operations. Uncertainty in cross-dock problems is inevitable and needs to be addressed. Almost all research in the cross-dock area assumes determinism. This dissertation considers uncertainty in cross-dock problems and optimizes these problems under uncertainty.
We consider uncertainty in processing times, using scenario-based and protection-based robust approaches. Using a heuristic method, we find a lower and upper bound and combine that with a meta-heuristic method to solve the problem. Also, we consider problems in two different industries (Goodwill and H-E-B) and address the uncertainties that happen frequently in their operations.
The scenario-based robust optimization model for the unloading problem using a min max objective is presented with examples. A surrogate heuristic procedure is used to find a robust solution. Next, a two-space genetic algorithm, a meta-heuristic procedure, is applied to the unloading problem using the bounds obtained by the heuristic procedure. The results are closer to the optimal solution than those obtained by the two-space genetic algorithm without bounds. When compared with the regular genetic algorithm with bounds, the two-space algorithm performs well.
The protection-based approach considers a limit on the number of coefficients allowed to change with data uncertainty, protecting against the degree of conservatism. The management of trucks and reduction of overtime pay in the cross-dock operations of Goodwill is addressed through two models and uncertainty is applied to those models. A combined cross-dock operations model together with demand is formulated and the uncertainties are discussed for H-E-B operations. This dissertation does not address the recycling operation within the cross-dock of Goodwill, or the uncertainty in H-E-B data.Civil, Architectural, and Environmental Engineerin
Dietary spices protect against hydrogen peroxide-induced DNA damage and inhibit nicotine-induced cancer cell migration
No full textAbstractSpices are rich sources of antioxidants due to the presence of phenols and flavonoids. In this study, the DNA protecting activity and inhibition of nicotine-induced cancer cell migration of 9 spices were analysed. Murine fibroblasts (3T3-L1) and human breast cancer (MCF-7) cells were pre-treated with spice extracts and then exposed to H2O2 and nicotine. The comet assay was used to analyse the DNA damage. Among the 9 spices, ginger, at 50μg/ml protected against 68% of DNA damage in 3T3-L1 cells. Caraway, cumin and fennel showed statistically significant (p<0.05) DNA protecting activity. Treatment of MCF-7 cells with nicotine induced cell migration, whereas pre-treatment with spices reduced this migration. Pepper, long pepper and ginger exhibited a high rate of inhibition of cell migration. The results of this study prove that spices protect DNA and inhibit cancer cell migration
Reduced complexity maximum likelihood detection for DAPSK based relay communication systems
No full textEnergy Efficient Constellation Rotation for Multiple-Symbol Differentially Encoded Communications
No full textPerformance analysis of generalized differential modulation using DAPSK for bi-directional relay networks
No full textPerformance analysis of decode and forward cooperative relaying protocol in MIMO Wireless Communication System
No full textInhibitory effects of fruit extracts on nitric oxide-induced proliferation in MCF-7 cells
No full textNitric oxide is a free radical involved in the pathogenesis of cancer by increasing tumour vascularization and metastasis. Studies using nitric oxide inhibitors have shown decrease in tumour growth and a role in cancer therapy. To analyse the effect of fruits on nitric oxide, we carried out experiments using a nitric oxide donor on the breast cancer cell line, MCF-7. Proliferating MCF-7 cells were treated with the methanolic extract of the fruits. The inhibitory activity of fruit extracts on cell proliferation was measured using the MTT assay. Chiku and dragon fruit showed high inhibitory activity when compared to the other fruits tested. The total polyphenol and flavonoid content and nitric oxide scavenging activity were found to be high in pomegranate, chiku, litchi, durian, grape and apple. This study shows that phytochemicals present in fruits scavenge nitric oxide and inhibit MCF-7 cell proliferation. © 2010 Elsevier Ltd. All rights reserved
