4,209 research outputs found
An interview with Alfredo Falcone and Lisa Salvatore: RECOURSE and trifluridine/tipiracil in metastatic colorectal cancer
No full textProfessor Alfredo Falcone and Dr Lisa Salvatore speak to Roshaine Gunawardana, Managing Commissioning Editor: Professor Alfredo Falcone is the Director of the Department of Oncology and the Specialization School at the University Hospital of Pisa, Italy. He trained in Pisa and Genoa, Italy, and has held major positions in Italian oncology since 2000. He currently has more than 300 publications, including papers in peer-reviewed international and national journals, book chapters, and more than 600 abstracts of presentations to international and national conferences. The majority of his papers regard clinical and translational research, with a particular focus on metastatic colorectal cancer. Dr Lisa Salvatore is a medical oncologist in the Department of Translational Research and New Technologies in Medicine and Surgery at the University of Pisa. She has been an author on about 40 publications in major peer-reviewed publications and has made numerous presentations in national and international conferences. Her main interest is focused on clinical and translational research in metastatic colorectal cancer
Education: An overview from the author of 'Cefiderocol as rescue therapy for Acinetobacter baumannii and other carbapenem-resistant Gram-negative infections in intensive care unit patients'
No full textThis video is a presentation from Professor Marco Falcone from the University Hospital Pisa, Italy, originally presented at the BSAC conference 'Into clinical practice: Meeting the challenges of Gram-negative infection management' on 14 October 2020. Professor Falcone highlights the cefiderocol compassionate use case series that has been published in Clinical Infectious Diseases (Falcone M, Tiseo G, Nicastro M et al. Cefiderocol as rescue therapy for Acinetobacter baumannii and other carbapenem-resistant Gram-negative infections in intensive care unit patients. Clin Infect Dis 2020; doi: 10.1093/cid/ciaa1410)
Chromoelectric flux tubes in QCD
No full textCardaci MS, Cea P, Cosmai L, Falcone R, Papa A. Chromoelectric flux tubes in QCD. Physical Review D. 2011;83(1): 014502.We analyze the distribution of the chromoelectric field generated by a static quark-antiquark pair in the SU(3) vacuum and revisit previous results for SU(2). We find that the transverse profile of the flux tube resembles the dual version of the Abrikosov vortex field distribution. We give an estimate of the London penetration length of the chromoelectric field in the confined vacuum. We also speculate on the value of the ratio between the penetration lengths for SU(2) and SU(3) gauge theories
De falcone Bartolusa de Saxoferrato
No full textDe falcone of Bartolus de SaxoferratoAmong the numerous texts by the famous Italian jurist Bartolus de Saxoferrato there is a short letter entitled tractatus de falcone — treaty of the falcon. Despite its name, it is neither a work about the issue of hunting with birds of prey, nor a letter exhausting the literary form of a treaty. Although Diplovatatius described it as consilium, it should be rather classified as quaestiones.It should be emphasized that the distinction of consilium, that is a legal advice drew up to consider the specific case from quaestio, theoretical analysis of some case, may be impossible. The more so that the basis for quaestiones were often genuine judicial cases, which were only changed with regards to identifying the parties and adjusting the case to the needs of teaching. The author made a translation of de falcone and added her own commentary.De falcone von Bartolus de SaxoferratoUnter zahlreichen Texten des berühmten italienischen Juristen, Bartolus de Saxoferrato, befindet sich ein ziemlich kleines Schriftstück unter dem Titel tractatus de falcone – eine Abhandlung über den Falken. Trotz eines solchen Namens ist das weder ein Werk über die Jagd mit Raubvögeln, noch ein Schriftstück, das die Merkmale der literarischen Form einer Abhandlung erfüllt. Obwohl Diplovatatius es als consilium bezeichnet hat, gehört es eher zu den quaestiones.Es ist hervorzuheben, dass sich die Unterscheidung zwischen consilium, also einer Rechtsberatung, die zwecks Erörterung einer konkreten Sache angefertigt wurde, und quaestio, also einer theoretischen Analyse eines Falles, als unmöglich erweisen kann. Um so mehr, dass authentische Gerichtsfälle den quaestiones oft als Grundlage dienten, man änderte an ihnen lediglich diese Details, die eine Identifizierung der Parteien erlauben würden und passte den Fall an den Bedarf der Didaktik an. Die Verfasserin hat die Abhandlung de falcone übersetzt und auch mit einem Kommentar versehen.De falcone of Bartolus de SaxoferratoAmong the numerous texts by the famous Italian jurist Bartolus de Saxoferrato there is a short letter entitled tractatus de falcone — treaty of the falcon. Despite its name, it is neither a work about the issue of hunting with birds of prey, nor a letter exhausting the literary form of a treaty. Although Diplovatatius described it as consilium, it should be rather classified as quaestiones.It should be emphasized that the distinction of consilium, that is a legal advice drew up to consider the specific case from quaestio, theoretical analysis of some case, may be impossible. The more so that the basis for quaestiones were often genuine judicial cases, which were only changed with regards to identifying the parties and adjusting the case to the needs of teaching. The author made a translation of de falcone and added her own commentary.De falcone von Bartolus de SaxoferratoUnter zahlreichen Texten des berühmten italienischen Juristen, Bartolus de Saxoferrato, befindet sich ein ziemlich kleines Schriftstück unter dem Titel tractatus de falcone – eine Abhandlung über den Falken. Trotz eines solchen Namens ist das weder ein Werk über die Jagd mit Raubvögeln, noch ein Schriftstück, das die Merkmale der literarischen Form einer Abhandlung erfüllt. Obwohl Diplovatatius es als consilium bezeichnet hat, gehört es eher zu den quaestiones.Es ist hervorzuheben, dass sich die Unterscheidung zwischen consilium, also einer Rechtsberatung, die zwecks Erörterung einer konkreten Sache angefertigt wurde, und quaestio, also einer theoretischen Analyse eines Falles, als unmöglich erweisen kann. Um so mehr, dass authentische Gerichtsfälle den quaestiones oft als Grundlage dienten, man änderte an ihnen lediglich diese Details, die eine Identifizierung der Parteien erlauben würden und passte den Fall an den Bedarf der Didaktik an. Die Verfasserin hat die Abhandlung de falcone übersetzt und auch mit einem Kommentar versehen
Reduced level of the histone deacetylase Sir2 in mRNA decapping mutants leads to silencing defects and premature aging
No full textRNA metabolism directly or indirectly impacts various cellular pathways.
Mutations in factors involved in mRNA decapping result in phenotypic markers of apoptosis and lead to premature aging. These traits are accompanied by elevated histone mRNA levels persisting throughout the cell cycle and defects in S-phase progression.
Here we show that decapping mutants exhibit low levels of Sir2, which reduces silencing and leads to the elevated transcription of rDNA intergenic spacer regions.
We postulate that defects in decapping are associated with the derepression of silencing at heterochromatic-like regions. This, in turn, may affect histone modification and induce loss of silencing at specific loci, as well as recombination within rDNA repeats, both of which have been shown to regulate cellular lifespan.
References
[1] Mazzoni C, Falcone C. Biochem Soc Trans. (2011), 39(5):1461-5. Review.
[2] Mroczek S & Kufel J (2008).Nucleic Acids Res 36, 2874-2888.
[3]Mazzoni C, Herker E, Palermo V, Jungwirth H, Eisenberg T, Madeo F & Falcone C (2005).EMBO Rep 6, 1076-108.
[4]Palermo V, Cundari E, Mangiapelo E, Falcone C & Mazzoni C (2010).Cell Cycle 9, 3991-3996.
[5] Thompson DM & Parker R (2007).Mol Cell Biol 27, 92-101
Endowing robots with self-modeling abilities for trustful human-robot interactions
No full textRobots involved in collaborative and cooperative tasks with humans cannot be programmed in all their functions. They are autonomous entities acting in a dynamic and often partially known environment. How to interact with the humans and the decision process are determined by the knowledge on the environment, on the other and on itself. Also, the level of trust that each member of the team places in the other is crucial to creating a fruitful collaborative relationship. We hypothesize that one of the main components of a trustful relationship resides in the self-modeling abilities of the robot. The paper illustrates how employing the model of trust by Falcone and Castelfranchi to include self-modeling skills in the NAO humanoid robot involved in trustworthy interactions. Self-modeling skills are then implemented employing features by the BDI paradigm
A spinorial decomposition of gl_4(R)
No full textWe determine six invariant subspaces of the 16-dimensional space gl_4(R)
under the conjugation by any element in Spin_3(R). Four of them add up to the
10-dimensional space of symmetric matrices and the other two add up to the
6-dimensional space of skew-symmetric matrices
A semi-Lagrangian scheme for the curve shortening flow in codimension 2
No full textWe consider the model problem where a curve in R^3 moves according to the mean curvature flow (the curve shortening flow). We construct a semi-Lagrangian scheme based on the Feynman–Kac representation formula of the solutions of the related level set geometric equation. The first step is to obtain an approximation of the associated codimension-1 problem formulated by Ambrosio and Soner, where the squared distance from the initial curve is used as initial condition. Since the e-sublevel of this evolution contains the curve, the next step is to extract the curve itself by following an optimal trajectory inside each e-sublevel. We show that this procedure is robust and accurate as long as the ‘‘fattening’’ phenomenon does not occur. Moreover, it can still single out the physically meaningful solution when it occurs
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