897 research outputs found
Il contributo del partenariato sociale al sistema sanitario nazionale: un’indagine empirica su ruolo e caratteristiche demografiche delle onlus
No full textIl contributo indaga l’impatto che le relazioni di PPP sociale esercitano sulla performance – finanziaria e non finanziaria – delle strutture ospedalie- re pubbliche, evidenziandone moda- lità di intervento e opportunità intrin- seche. È stata condotta un’analisi empirica valutando la centralità che il ruolo intrapreso dalle organizzazioni non-profit e le loro caratteristiche di corporate governance possono assume- re nella determinazione del successo della collaborazione. Lo studio è stato circoscritto alle relazioni di partena- riato pubblico-privato, attive nell’anno 2019, in 6 regioni italiane, selezionate sulla base dei punteggi conseguiti sui Livelli Essenziali di Assistenza (LEA)
A concept analysis on academic psychological distress: Implications for clinical practice
No full textThe aim of this paper was to provide a conceptual clarification of the emerging construct of academic psychological distress (APD). Based on the concept analysis method of Walker and Avant, attributes, antecedents, contributing factors, and consequences were isolated. Empirical referents were discussed, and model, borderline, and contrary cases were provided. In March 2024, a systematic search without time limit was conducted in the PsycINFO, PubMED, and SCOPUS databases according to the PRISMA method. Sixty-two articles met the inclusion criteria. The analysis of the literature revealed that APD is a negative emotional reaction that a student may exhibit in the face of perceived stressors in the university environment. In terms of defining attributes, it appears to be characterized primarily by anxiety and depressive states, accompanied by cognitive problems, somatic symptoms, and social impairment. Isolated antecedents include: low academic skills and dispositions, negative academic self-perception, and negative perceptions of various aspects of the university environment (teachers, peers, parents’ academic-related expectations, academic climate and study program). Dysfunctional coping, insecure attachment, maladaptive perfectionism, and low levels of social support were found to be contributing factors. Other risk variables included being a first-generation student and co-occurring psychopathology. The consequences of APD were poor academic performance, dropping out, and poorer mental health. Recommendations for research and clinical practice are provided
“Salmo salar ribonuclease: structural and functional evidences of an auto inhibition mechanism”
No full textThe pancreatic-type ribonucleases (ptRNases) constitute one of the most investigated family of homologous proteins [1]. PtRNases have been found in various organs and tissues of mammals, amphibians, reptiles, birds [2] and, more recently, fish. In particular, seven new RNases were identified in two teleosts: five from Zebrafish (ZF RNases) and two from Salmo Salar (Ss-RNase-1 and Ss-RNase-2) [3-5]. We have focused our attention on the latter enzyme, which is the most active fish RNase, although its activity is much lower than that of the other members of the ptRNase family.
The crystallographic structure of Ss-RNase-2 (SS2) shows the typical V-shape structure of pancreatic-like ribonucleases, with three helices and six β-strands connected by loops and turns. The electron density in the active site region is discontinuous. In particular, the position of His 113, one of the residues of the catalytic triad that is usually very well defined, cannot be unambiguously identified. Furthermore, the segment Val117-Ile121, which is well-structured and anchored to the protein body, partially obstructs the active site. These structural features suggest that SS2 is in a sort of inhibited state. It is reasonable to hypothesize that, in consequence of an interaction with a specific ligand, the C-terminal segment moves to free the active site. To define the activation mechanism of SS2, we have designed and characterized two deletion mutants: SS2-des117-121, in which the chain segment that in the wild-type protein obstructs the active site has been removed, and SS2-des119-126, in which the elimination of the last eight residues of the chain might allow the sliding of the obstructing segment out of the active site. Interestingly, the crystallographic structure of SS2-des117-121 shows a well-defined active site, almost free of obstructions. Furthermore, the enzymatic activity assays show an improvement of the specific activity of SS2-des117-121 with respect to the wild-type protein. On the bases of these findings, we have proposed an intriguing auto-inhibition mechanism for SS2. The details will be discussed at the Meeting.
[1] L. Aravind, E.V. Koonin Methods Enzymol. 2001, 341, 3.
[2] S. Cho, J.J. Beintema, J. Zhang Genomics. 2005, 85, 208.
[3] E. Pizzo, P. Buonanno, A. Di Maro, S. Ponticelli, S. De Falco, N. Quarto, M.V. Cubellis, G. D'Alessio J Biol Chem. 2006, 281, 27454.
[4] Pizzo, E., Merlino, A., Turano, M., Russo Krauss, I., Coscia, F., Zanfardino, A., Varcamonti, M., Furia, A., Giancola, C., Mazzarella, L., Sica, F., D'Alessio, G. Bioch. J. 2010, 433(2), 345-355
[5] E. Pizzo, M. Varcamonti, A. Di Maro, A. Zanfardino, C. Giancola, G. D'Alessio FEBS J. 2008, 275, 1283
Coronally advanced flap with or without enamel matrix derivative for root coverage: a 2-year study.
No full textThe purpose of this study was to assess the ability of enamel matrix derivative (EMD) to improve root coverage with a coronally advanced flap (CAF) during a 2-year follow-up. Methods: Fifteen patients each with two single and similar bilateral Miller Class I or II gingival recessions (30 recessions) were selected. Each recession was randomly assigned to the test group (CAF+EMD) or the control group (CAF only). Clinical parameters recorded at baseline and at 6, 12 and 24 months were recession depth (R), recession width (WR), probing depth (PD), clinical attachment level (CAL) and keratinized tissue (KT). Results: Reduction of R resulted in a significant CAL gain in both groups, whereas PD was not altered. In the test group, R decreased from 4.07 mm (SD ± 0.59) at baseline to 0.47 mm (SD ± 0.74) at 24 months, corresponding to a mean root coverage (MRC) of 90.67%, whereas in the control group R shrank from 4.13 mm (SD ± 0.74) at baseline to 0.60 mm (SD ± 0.83) at 24 months (MRC = 86.67%). Complete root coverage was achieved at 24 months in 73.33% and 60% of the two groups. A significant KT increase was observed in both groups. Conclusions: Root coverage outcomes were similar in both groups and no statistically significant differences were found at all between them. Hence, the additional use of EMD to CAF is not justified for clinical benefits of root coverage, but as an attempt of achieving periodontal regeneration rather than repai
Environmental reporting in public sector organizations: A review of literature for the future paths of research
No full textThis article aims to determine a comprehensive resume of environmental reporting (ER) in the public sector recognizing its role in achieving the environmental sustainable development goals (SDGs). A structured literature review was conducted by content and bibliometric analysis as well as applying the analytical framework by Manes Rossi et al. (2020) to draft the state-of-the-art of ER in public sector organizations and link them to the environmental SDG targets. The analysis develops insights and critical reflections on emerging research areas related to biodiversity disclosure, climate change, and carbon emission disclosure, including ER from a general perspective in the public sector and identifies future research paths that deserve in-depth-investigation. The originality of our study derives from the proposal of a set of renewed streams of research addressed to academics and practical communities as well as to decision-makers and policymakers in taking urgent action to be compliant with emerging legislative issues and to be accountable toward stakeholders in preventing climate change and combating environmental impacts
Higher education system and doctoral programmes: a renewed multi-criteria evaluation model of European Accounting Doctoral Programmes
No full textPurpose – This paper aims to define a hierarchical and multi-criteria framework based on pillars of the Modernization of Higher Education to evaluate European Accounting Doctoral Programmes (EADE-Model).
Design/methodology/approach – The authors applied a quali-quantitative methodology based on the analytic hierarchy process and the survey approach. The authors conducted an extensive literature and regulation review to identify the dimensions affecting the quality of Doctoral Programmes, choosing accounting as the relevant and pivotal field. The authors also used the survey to select the most critical quality dimensions and derive their weight to build EADE Model. The validity of the proposed model has been tested through the application to the Italian scenario.
Findings – The findings provide a critical extension of accounting ranking studies constructing a multicriteria, hierarchical and updated evaluation model recognizing the role of doctoral training in the knowledgebased society. The results shed new light on weak areas apt to be improved and propose potential
amendments to enhance the quality standard of ADE.
Practical implications – Theoretical and practical implications of this paper are directed to academics, policymakers and PhD programmes administrators.
Originality/value – The research is original in drafting a hierarchical multi-criteria framework for evaluating ADE in the Higher Education System. This model may be extended to other fields
Progetto UE - S.I.S.M.A. - System integrated for security management activities - Sistema integrato per la prevenzione e la tutela del tessuto edilizio storico dal rischio sismico - (Programma Interreg IIIB)
No full textEpidemiological data on chemical poisoning of animals: a source for risk assessment
No full textChemicals, included in the category of pesticides (n.1159 cases), insecticides, rodenticides, molluscicides, herbicides and fungicides, and household products (n. 191 cases), are among the main classes involved in animal poisoning. Epidemiological studies were carried out from 2010 to 2013 based on the Human Poison Control Centre of Milan (Centro Antiveleni di Milano, CAV) data related to domestic animal poisoning, in collaboration with the Veterinary Toxicology Section of the University of Milan. Data, processed for epidemiological analysis and evaluated in terms of the animal species, toxic substance, clinical signs and final outcome, were classified and represent an interesting database of chemical exposure. Most of the suspected poisoning cases were related to anticholinesterase insecticides, carbamates (methomyl), organophosphates (chlorpyriphos), and pyrethrins-pyrethroids. Frequently reported cases involved rodenticides such as anticoagulants, zinc phosphide, chlorophacinone, α-chloralose together with the molluscicides metaldehyde and methiocarb, in cases involving pets. Occasionally, the herbicides paraquat and glyphosate and fungicides like copper sulphate, copper oxychloride, ziram were reported. Caustic agents like sodium hydroxide, a drain cleaner also known as caustic soda and detergents and other frequent household toxicants such as solvents (hydrocarbons) used in paints and domestic fuel, fertilizers and ethylene glycol, used as an anti-freeze, are culprits causing intoxication. Epidemiological data collected can be a useful source and a key tool for chemical risk assessment.
References:
Caloni F, Cortinovis C, Rivolta M, Davanzo F Animal poisoning in Italy: 10 years of epidemiological data from the Poison Control Centre of Milan, 2012, Veterinary record 170, 415
Caloni F Berny P, Croubels S, Sachana M,Guitart R Epidemiology of poisonings in Europe, 2012, Chapter 7 pp 88-97 Veterinary Toxicology, Editor R. Gupta,2nd Edition
Caloni F, Cortinovis C, Pizzo F, Rivolta M, Panzavolta G, Falciola C, Davanzo F Poisoning of domestic animals: 2011 data from poison control centre of Milan, 2012, Toxicology letters, 214, 211S
Caloni F, Cortinovis C, Pizzo F, Rivolta M, Davanzo F. Poisoning of domestic animals data from Poison Control Centre of Milan, 2012, Toxicology letters, 221, S25
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