13,035 research outputs found
Pediatric ENT Infections
No full textThe book provides a comprehensive and up-to-date overview of pediatric ENT infections. It brings together the experience of authors from more than 30 countries and aims to provide a broader understanding of the prevention and treatment of infectious diseases in children, that will likely lead to improve their health globally. In addition to new infections like COVID-19, the work reviews the latest treatments modalities. The list of topics ranges from basic to very advanced and the book will be therefore an invaluable resource for ENT and pediatrics trainees and students, as well as for experienced practitioners in these fields. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
ENT-ABIETANE DITERPENES FROM Euphorbia phosphorea (EUPHORBIACEAE)
No full textPhytochemical study of the roots of Euphorbia phosphorea Mart. (Euphorbiaceae) was carried out through chromatographic techniques, resulting in the isolation of a new ent-abietane diterpene named 11β,12β-dihydroxy-ent-abieta-8(14),13(15)-dien-16,12α-olide (1), and of nine known ent-abietane diterpenes jolkinolide A (2), jolkinolide E (3), euphorin H (4), euphopilolide (5) jolkinolide F (6), ent-12-hydroxy-12[R]-abieta-8(14),13(15)-dien-16,12-olide (7), ent-11α-hydroxyabieta-8(14),13(15)-dien-16,12α-olide (8), 17-hydroxyjolkinolide B (9) and caudicifolin (10). The structures of all compounds were established using spectroscopic techniques such as 1D and 2D NMR, and the structure of the compound 1 was established also with MS, IR and ECD. All compounds were submitted to an in silico study through of a predictive model and then submitted to in vitro tests against Mycobacterium tuberculosis and M. smegmatis for evaluation of their antimycobacterial activity. Compounds 5 and 9 showed mycobacterial growth inhibition with MIC values of 62.5 μM against M. tuberculosis and M. smegmatis, respectively.</div
Postpartum ent emergencies
No full textMany ear, nose and throat (ENT) emergencies occur during postpartum period. Most of these emergencies are benign; however, there are certain ENT disorders that are critical and require immediate intervention. Several studies have been published that have improved the knowledge of the pathophysiology of these conditions and helped us define appropriate investigations and management for these conditions
Nutritional Management of Pediatric Ent Infections
No full textNutrition is the science that investigates how nutrients and food compounds nourish one’s body and interact with health and disease [1]. Although the relationship between diet and disease occurrence, prevention and treatment have been studied extensively [2], the interaction between nutritional status and ENT infections has been heavily understudied, especially among pediatric populations [3]. Nutritional care should be as specialized as medicine; thus, nutritional management of ENT infections needs to be tailored towards the personalized medical needs of the patients. Healthy and balanced nutrition not only maintains proper growth and development in children, but also decreases the risk of morbidity and mortality [4]. As both health care practitioners and parents become more aware of the impact of nutrition in acute and chronic diseases, it is essential to understand nutrition’s role in managing health and disease risk reduction [5]. Also, since parents feed their children daily, empowering them with the knowledge of a healthy diet would enhance their involvement and confidence in caring for the patients. Therefore, the aim of this chapter is to provide an overview of the nutritional assessment and treatment to reduce the burden of pediatric ENT infections. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
ENT diseases: Diagnosis and treatment during pregnancy and lactation
No full textThe book offers a comprehensive overview of ENT diseases during pregnancy, postpartum and lactating period. It brings together the experience of authors from more than 25 countries and aims to provide a broader understanding of the diagnosis, prevention and treatment of the ENT pathologies in pregnant and lactating women. The book is organized in 7 main parts according to the ENT subspecialties, and each chapter features a reader-friendly, uniform structure. It includes developments about COVID-19 infection. ENT Diseases: Diagnosis and Treatment during Pregnancy and Lactation will appeal to a wide readership, from ENT practitioners through allergists and pulmonologists, to trainees and students in ENT, obstetrics/gynecology. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022. All rights reserved
ent-Abietanoids and ent-Isopimaranoid Glycosides from Isodon nervosus
No full textThree new and one known ent-abietanoids. i.e.. ent-abienervonins A-C (1-3, resp.) and hebeiabinin B (4), and two new ent-isopimaranoid glycosides, i.e. ent-isopimanervosides A and B (5 and 6, resp.). along with seven known phenolic glycosides were isolated front the aerial parts of Isodon nervosus. The structures of the new compounds were clucidated on the basis of spectroscopic and chemical evidence
Ent-abietane and ent-labdane diterpenoids from Isodon parvifolius
No full textA phytochemical investigation on the leaves of Isodon parvifolius yielded three new ent-abietanoids parvifolines L-N (1-3), together with five known ent-abietanoids (4-8) and one known ent-labdane diterpenoid (9). Their structures were determined on the basis of extensive spectroscopic analysis
Cytotoxic ent-kauranoids from Isodon parvifolius
No full textThree new ent-kaurane diterpenoids, parvifoline Z (1), parvifoline AA (2), and parvifoline (3), together with 14 known compounds, were isolated from the leaves of Isodon parvifolius. The structures of the new compounds were elucidated by 1D- and 2D-NMR spectroscopy and mass spectrometry, and by comparison with known compounds. These three new diterpenoids included three types of ent-kauranoids, namely, C(20)-non-oxygenated-ent-kauranoid, 7,20-cyclo-ent-kauranoid and 6,7-seco-entkauranoid-7,20-olide. Compounds I and 2 exhibited significant cytotoxicities against A549, HT-29, and K562 cell lines (Table 2)
Ent-clerodane and ent-trachylobane diterpenoids from Croton dictyophlebodes
Get PDFThe stem bark and root bark extracts of Croton dictyophlebodes (Euphorbiaceae) yielded seven undescribed ent-clerodanes: 15,16-epoxy-17,12(S)-olide-ent-cleroda-1,3,13(16),14-tetraen-18-oic acid methyl ester (crotodictyo A), 3β,4β:15,16-diepoxy-ent-cleroda-13(16),14-dien-20-al (crotodictyo B), 3β,4β:15,16-diepoxy-ent-cleroda-13(16),14-dien-19,20-dioic acid (crotodictyo C), 3β,4β:15,16-diepoxy-ent-cleroda-13(16),14-dien-20,19-olide (crotodictyo D), 3β,4β:15,16-diepoxy-20,12(R)-olide ent-cleroda-13(16),14-dien-19-oic acid methyl ester (crotodictyo E), 15,16-epoxy-ent-cleroda-3,13(16),14-trien-12-oxo-18-oic acid (crotodictyo F) and 15,16-epoxy-ent-cleroda-1,3,13(16),14-tetraen-12-oxo-18-oic acid (crotodictyo G), in addition to 15,16-epoxy- ent-cleroda-3,13(16),14-trien-12-oxo-18-oic acid methyl ester (crotodictyo H), reported previously as a synthetic derivative, and acetyl aleuritolic acid. The root extract yielded two ent-trachylobanes, ent-trachylobane-18,19-diol, the undescribed ent-trachylobane-2α,19-diol, along with ent-kaur-16-en-19-oic acid and 2-methoxybenzyl benzoate. Compounds were evaluated against the NCI 60 panel of human tumour cell lines at a single dose of 10−5 M, but showed no significant activity
A new ent-labdane diterpenoid from Andrographis paniculata
No full textA new ent-labdane diterpenoid, 19-O-beta-D-glucopyranosyl-ent-labda-8(17),13-dien-15,16,19-triol, together with six known ent-labdane diterpenoids, was isolated from the aerial parts of Andrographis paniculata. The structure of the new compound was elucidated by extensive spectral analysis. (C) 2010 Li Sheng Ding. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved
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