864 research outputs found
Chemical structures of Pt(R,R-DACH) and Pt(S,S-DACH).
No full text<p>Chemical structures of Pt(R,R-DACH) and Pt(S,S-DACH).</p
AFM images of 2-kb DNA incubated with Pt-DACH.
No full text<p>(A) In the absence of Pt-DACH treatment. (B) The concentration was 60 µM for both Pt(R,R-DACH) and Pt(S,S-DACH). The molar ratio of Pt-DACH complex to nucleotide, <i>r<sub>i</sub></i>, was about 3. “R” and “S” represent Pt(R,R-DACH) and Pt(S,S-DACH), respectively. “1″ and “2″ represent incubation times of 2 h and 24 h, respectively. The micro-loop was marked by the black arrow. The large-sized micro-loop was marked by the blue arrow. (C) The concentration was 600 µM for both Pt(R,R-DACH) and Pt(S,S-DACH). <i>r<sub>i</sub></i> was about 30. “1″, “2″, “3″ and “4″ represent incubation times of 1 h, 2 h, 4 h and 8 h, respectively. The long-range cross-link was marked by the green arrow. All images were of the same size, and the scale bar was 300 nm.</p
Navigation mit Satelliten: die Zukunft hat bereits begonnen. Geomatik Herbstkolloquium, FHNW Muttenz
No full textUnterthänigstes Geleit Welches Dem Durchläuchtigsten Fürsten und Herrn/ Herrn Fridrich Wilhelm/ Marggraffen zu Brandenb. ... Meinen gnädigsten Chur-Fürsten und Herrn/ Als Seine Chur-Fürstl. Durchl. mit Dero ... Gemahlin der Chur-Fürstinnen und dem jüngstgebohren ... Printzen sich aus ihrem Hertzogthum Preussen 1657. 16. Weinmon. erhoben und in Dero andere Erbländer sich begeben/ Schuldigst gegeben ich Simon Dach
No full textUNTERTHÄNIGSTES GELEIT WELCHES DEM DURCHLÄUCHTIGSTEN FÜRSTEN UND HERRN/ HERRN FRIDRICH WILHELM/ MARGGRAFFEN ZU BRANDENB. ... MEINEN GNÄDIGSTEN CHUR-FÜRSTEN UND HERRN/ ALS SEINE CHUR-FÜRSTL. DURCHL. MIT DERO ... GEMAHLIN DER CHUR-FÜRSTINNEN UND DEM JÜNGSTGEBOHREN ... PRINTZEN SICH AUS IHREM HERTZOGTHUM PREUSSEN 1657. 16. WEINMON. ERHOBEN UND IN DERO ANDERE ERBLÄNDER SICH BEGEBEN/ SCHULDIGST GEGEBEN ICH SIMON DACH
Unterthänigstes Geleit Welches Dem Durchläuchtigsten Fürsten und Herrn/ Herrn Fridrich Wilhelm/ Marggraffen zu Brandenb. ... Meinen gnädigsten Chur-Fürsten und Herrn/ Als Seine Chur-Fürstl. Durchl. mit Dero ... Gemahlin der Chur-Fürstinnen und dem jüngstgebohren ... Printzen sich aus ihrem Hertzogthum Preussen 1657. 16. Weinmon. erhoben und in Dero andere Erbländer sich begeben/ Schuldigst gegeben ich Simon Dach ([1]r)
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High performance liquid chromatography on (R,R)-DACH-DNB chiral stationary phase using CO2 based eluents
No full textFast and efficient sepns. of chiral stereolabile compds. were obtained at very low temp. on a π-acid chiral stationary phase, dinitrobenzoyl deriv. of diaminocyclohexane modified silica gel (R,R-DACH-DNB), using carbon dioxide-based mobile phases contg. alc. polar modifiers. Furthermore, efficient sepns. of the newly discovered spherical carbon cluster buckminsterfullerene (C60) and the related higher fullerenes (C70, etc.) have been performed on the same stationary phase using eluents based on either n-hexane or carbon dioxid
Effects of Loading Value of Wang Resins on the Resolution of Benzoin and α-Benzoin Oxime Using (R,R)-Diaminocyclohexane (DACH) Derivatives
No full text39 p.(R,R)-Diaminocyclohexane (DACH) is a well-studied chiral reagent used in asymmetric synthesis and resolution of enantiopure product. The monobenzylation product of (R,R)-DACH with 3,4-dimethoxybenzaldehyde was linked to the polystyrene resin Wang in order to conduct solid phase chemistry resulting in a chemical environment more favorable to R-benzoin and R-α benzoin oxime. Racemic benzoin and α-benzoin oxime were resolved with the synthetic resin and bound via hydrogen bonding. Wang resins containing three different loading values 1.06, 0.96, and 0.87 mmol/mg were tested to determine the effects of resin substitution on the enantiomeric excess or reagent bound. The resins were stripped of their hydrogen bound reagents which were separated using High performance liquid chromatography on a chiral column. Ultraviolet/visible light absorbance measurements found that in all cases the resin bound the (R)-benzoin and oxime enantiomer in excess. Between resins, there was no significant difference in affinity for (R) oxime, but there were significant differences between resins of various loading values for benzoin
Oxaliplatin and [Pt(R,R-DACH)(panobinostat-2H)] show nanomolar cytotoxicity towards diffuse intrinsic pontine glioma (DIPG)
No full textWe report the synthesis of two novel platinum(II) complexes which incorporate histone deacetylase (HDAC) inhibitors: [PtII(R,R-DACH)(Sub-H)] (1), [PtII(R,R-DACH)(panobinostat-2H)] (2), where SubH = suberoyl-bis-hydroxamic acid; DACH = (1R,2R)-(–)-1,2-diaminocyclohexane and panobinostat = (E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide. Complexes 1 and 2 were characterised by 1H, 13C, 195Pt NMR spectroscopy and ESI-MS. Whilst oxaliplatin demonstrated considerable cytotoxicity in two patient-derived low-passage paediatric glioma DIPG cell lines (IC50 values of 0.333 μM in SU-DIPG-IV, and 0.135 μM in SU-DIPG-XXI), complex 2 showed even greater cytotoxicities, with IC50 values of 0.021 μM (SU-DIPG-IV), 0.067 μM (BIOMEDE 194) and 0.009 μM (SU-DIPG-XXI). Complex 2 also demonstrated superior aqueous solubility in comparison to panobinostat. Complex 2 released free intact panobinostat under HPLC conditions, as determined by ESI-MS. Incubation of solutions of oxaliplatin (H2O) and panobinostat (DMF) resulted in instantaneous reactivity and precipitation of a panobinostat derivative which was not a platinum complex; the same reactivity was not observed between carboplatin and panobinostat
Average stretching distance (<i>L<sub>sd</sub></i>) of 2-kb DNA incubated with Pt-DACH.
No full text<p>(A) The concentration was 60 µM for both Pt(R,R-DACH) and Pt(S,S-DACH). (B) The concentration was 600 µM for both Pt(R,R-DACH) and Pt(S,S-DACH). All data were the mean of approximately 150 DNA molecules. The error bars corresponded to 95% confidence intervals. Inset: an illustration of the definition of stretching distance.</p
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