1,031 research outputs found

    13 - Modeling the post-LGM deglaciation of the Scandinavian-Barents Sea Ice Sheet: a model intercomparison approachM. Petrini, N. Kirchner, F. Colleoni, A. Camerlenghi, M. Rebesco, R.G. Lucchi, R. Noormets, E. Forte, R.R. Colucci

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    ARCA Project - Final Conference, 11 October 2016 Rome - Poster Session - Marine Geology - Extended abstract(M. Petrini, N. Kirchner, F. Colleoni, A. Camerlenghi, M. Rebesco, R.G. Lucchi, R. Noormets, E. Forte, R.R. Colucci)</div

    Quantitative Analysis

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    The programme aims to facilitate global and interconnected learning about the contexts, causes and factors leading to vaccine engagement. Through the programme, the Academy has awarded funding to seven research projects exploring vaccine engagement in Canada, France, Germany, Italy, Japan and the UK. The programme, which was funded by the UK’s Department for Business, Energy and Industrial Strategy, builds on a series of statements developed in partnership with humanities and social sciences bodies across G7 countries. The Academy has supported another series of projects focused on the USA and UK

    Publisher correction: Spatio-temporal variability of processes across Antarctic ice-bed-ocean interfaces (vol 9, 2289, 2018)

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    The original version of this Article contained an error in the spelling of the author Florence Colleoni, which was incorrectly given as Florence Colloni. This has been corrected in both the PDF and HTML versions of the Article

    Two-year infant neurodevelopmental outcome after single or multiple antenatal courses of corticosteroids to prevent complications of prematurity.

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    Objective: This study was undertaken to evaluate the effect of exposure to multiple antenatal steroid courses on short-term neonatal morbidity and 2-year infant neurodevelopmental outcome. Study design: This was a prospective observational study of 201 preterm singleton infants who received 1 or more courses of corticosteroids to prevent complications of prematurity and weredelivered between 24 and 34 weeks’ gestation at a single institution. Neurodevelopmental outcome of the infants was evaluated at 2 years corrected age. Logistic regression analysis was used to perform multivariate analyses of associations and trends. Results: One hundred thirty-eight subjects (68.7%) received at least 1 complete course of betamethasone, whereas 63 (31.3%) patients were treated with dexamethasone. The prevalence of multiple steroid doses exposure was 26.8% (37/138) in betamethasone and 52.4% (33/63) in dexamethasone group. The prevalence of infant leukomalacia, including both prolonged echogenicity and cystic leukomalacia, was 25.9% (34/131) after a complete corticosteroid course, 40% (6/15) after 1, 42.3% (12/28) after 2, and 44.4% (12/27) after more than 2 additional courses, respectively (adjusted P for trend=.011). In the same categories of steroid exposure, the corresponding prevalences of 2-year infant neurodevelopmental abnormalities were 18% (20/111), 21.4% (3/14), 29.2% (7/24), and 34.8% (8/23), respectively (adjusted P for trend=.038). Multivariate study of first grade interaction suggested that the risk of leukomalacia and 2-year infant neurodevelopmental abnormalities associated with multiple doses exposure was confined to dexamethasone. In fact, compared with betamethasone, exposure to multiple doses of dexamethasone was associated with an increased risk of leukomalacia (19/33 compared with 11/37; odds ratio [OR]=3.21, 95% CI=1.07-9.77) and overall 2-year infant neurodevelopmental abnormalities (12/28 compared with 6/35; OR=3.63, 95% CI=1.03-13.58)

    UTERINE MYOMA IN POSTMENOPAUSE: A COMPARISON BETWEEN TWO THERAPEUTIC SCHEDULES OF HRT

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    The aim of the present study is to evaluate the effects of two different hormonal treatment schedules on the risk of uterine myoma onset or progression. Percutaneous-oral schedule of HRT seems to affect the growth of uterine myomas more than a single oral combination of oestradiol valerate and cyproterone acetate

    Somatic cell nuclear transfer in horses.

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    The cloning of equids was achieved in 2003, several years after the birth of Dolly the sheep and also after the cloning of numerous other laboratory and farm animal species. The delay was because of the limited development in the horse of more classical-assisted reproductive techniques required for successful cloning, such as oocyte maturation and in vitro embryo production. When these technologies were developed, the application of cloning also became possible and cloned horse offspring were obtained. This review summarizes the main technical procedures that are required for cloning equids and the present status of this technique. The first step is competent oocyte maturation, this is followed by oocyte enucleation and reconstruction, using either zona-enclosed or zona-free oocytes, by efficient activation to allow high cleavage rates and finally by a suitable in vitro embryo culture technique. Cloning of the first equid, a mule, was achieved using an in vivo-matured oocytes and immediate transfer of the reconstructed embryo, i.e. at the one cell stage, to the recipient oviduct. In contrast, the first horse offspring was obtained using a complete in vitro procedure from oocyte maturation to embryo culture to the blastocyst stage, followed by non-surgical transfer. Later studies on equine cloning report high efficiency relative to that for other species. Cloned equid offspring reported to date appear to be normal and those that have reached puberty have been confirmed to be fertile. In summary, horse cloning is now a reproducible technique that offers the opportunity to preserve valuable genetics and notably to generate copies of castrated champions and therefore, offspring from those champions that would be impossible to obtain otherwise
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