6,659 research outputs found
The Family History of Chase Theodore Uhlich
No full textThe Family History of
Chase T. Uhlich
28 November 2022
Chase T. Uhlich authored this family history as part of the course requirements for HIST 550/700 Your Family in History offered online in Fall 2022 and was submitted to the Pittsburg State University Digital Commons. Please contact the author directly with any questions or comments: [email protected]
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License
Letter from William Chase to George Draper (April 3, 1940)
No full textA letter from William R. Chase to George O. Draper, alumni secretary at Springfield College. The letter is dated April 3, 1940. In the letter, William Chase recounts a panel that he sat on for his Church in New Bedford. He states that the panel had three men who played the game of basketball when it was first created. One was Allison R. Dorman who attended the Armory Hill YMCA and said that Naismith experimented with the game with him and the other other boys at the YMCA. The other was George T. Ferguson who said that they played the game during the Summer School of 1891 at Springfield College. A G.T. Ferguson is listed and pictured with the students of the 1891 Summer School.William R. Chase is a member of Class 1893 of Springfield College (then known as International YMCA Training School). He was a member of the first men to ever play the game of basketball in 1891. Chase was born on June 23, 1867 in New Bedford, Massachusetts. Before attending Springfield College, he worked in a music store, a bank, and for an insurance agency. He operated his own insurance business in New Bedford for 50 years before retiring in March, 1947. He died on August 30, 1951
Editorial: The Century magazine
No full textThis 8-page series of correspondence between C. P. Ambler, R. U. Johnson, and J. T. Rothrock discusses an editorial that Ambler sent to The Century Magazine. The Century Magazine suggests gathering photographs to show to members of Congress. In promoting a national park in the southern Appalachians, Chase Ambler wrote dozens of editorials that were submitted to newspapers and magazines throughout the east coast. After the editorials were published, the Appalachian National Park Association often reprinted and circulated them as part of their promotional campaign. Chase P. Ambler (1865-1932) was a founding member and long-time secretary of the association
The t(8;17)(p11;q23) in the 8p11 myeloproliferative syndrome fuses MYO18A to FGFR1
No full textThe 8p11 myeloproliferative syndrome (EMS) also known as stem cell leukemia-lymphoma syndrome (SCLL) is associated with translocations that disrupt FGFR1. The resultant fusion proteins are constitutively active tyrosine kinases, and different FGFR1 fusions are associated with subtly different disease phenotypes. We report here a patient with a t(8;17)(p11;q23) and an unusual myelodysplastic/myeloproliferative disease (MDS/MPD) characterized by thrombocytopenia due to markedly reduced size and numbers of megakaryocytes, with elevated numbers of monocytes, eosinophils and basophils. A novel mRNA fusion between exon 32 of the myosin XVIIIA gene (MYO18A) at chromosome band 17q11 and exon 9 of FGFR1 was identified. Partial characterization of the genomic breakpoints in combination of bubble-PCR with fluorescence in situ hybridization revealed that the t(8;17) arose from a three-way translocation with breaks at 8p11, 17q11 and 17q23. MYO18A-FGFR1 is structurally similar to other fusion tyrosine kinases and is likely to be the causative transforming lesion in this unusual MDS/MPD
Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074
No full textThe t(4;14)(p16.3;q32), associated with 10-20% of cases of multiple myeloma (MM), deregulates the expression of MMSET and FGFR3. To assess the potential of FGFR3 as a drug target, we evaluated the effects of selective inhibitors on MM and control cell lines. SU5402 and PD173074 specifically inhibited the growth of the two t(4;14)-positive MM lines, KMS-11 and OPM-2. Importantly, inhibition was still observed in the presence of IL-6, a growth factor known to play an important role in MM. Both compounds induced a dose-dependent reduction in cell viability and an increase in apoptosis, accompanied by a decrease in extracellular signal-related kinase phosphorylation. In contrast, no inhibition was seen with either compound against t(4;14)-negative cell lines or NCI-H929, a t(4;14)-positive, FGFR3-negative MM cell line. FGFR3 is thus a plausible candidate for targeted therapy in a subset of MM patients
Submission to the Connecticut Commission on Judicial Compensation / by Chief Justice Chase T. Rogers
No full text1 online resource (20 pages) : color illustrations"October 3, 2012."; Imprint from letter of transmittal; This past legislative session, Governor Malloy proposed, and the General Assembly enacted, Public Act 12-93, An Act Establishing a Commission on Judicial Compensation ..."--Page 2; Includes bibliographical reference
Using simulation to estimate the cost effectiveness of improving ambulance and thrombolysis response times after myocardial infarction
No full textObjectives: To quantify the health gains and costs associated with improving ambulance and thrombolysis response times for acute myocardial infarction.
Design: A computer simulation model.
Patients/setting: Patients experiencing acute myocardial infarction in England.
Interventions: Improving the ambulance response time to 75% of calls reached within 8 minutes and the hospital arrival to thrombolysis time interval (door-to-needle time) to 75% receiving it within 30 minutes and 20 minutes, compared to best estimates of response times in the mid-1990s.
Main outcome measures: Deaths prevented, life years saved, and discounted cost per life year saved.
Results: Improving the ambulance response to 75% of calls within 8 minutes resulted in an estimate of 5 deaths prevented or 57 life years saved per million population per year, with a discounted incremental cost per life year saved of 8540 pound over 20 years. The corresponding benefit of improving the door-to-needle time to 75% of myocardial infarction patients within 30 minutes was an estimated 2 deaths prevented and 15 life years saved per million population per year, with a discounted incremental cost per life year saved of between 10 pound 150 to 54 pound 230 over 20 years. Little further gain was associated with reaching the 20 minute target. Combining ambulance and thrombolysis targets resulted in 70 life years saved per million population per year.
Conclusions: Improving ambulance response times appears to be cost effective. Reducing door-to-needle time will have a smaller effect at an uncertain cost. Further benefits may be gained from reducing the time from onset of symptoms to starting thrombolysis
A model-based quantification of nonlinear expiratory resistance in Plethysmographic data of COPD patients
No full textBackground: Chronic obstructive pulmonary disease (COPD) is characterised by airway obstruction with an increase in airway resistance (R) to airflow in the lungs. An extreme case of expiratory airway resistance is
expiratory flow limitation, a common feature of severe COPD. Current analyses quantify expiratory R with linear
model-based methods, which do not capture non-linearity’s noted in COPD literature. This analysis utilises a
simple nonlinear model to describe patient-specific nonlinear expiratory resistance dynamics typical of COPD
and assesses its ability to both fit measured data and also to discriminate between severity levels of COPD.
Methods: Plethysmographic data, including alveolar pressure and airway flow, was collected from n=100 subjects
(40 healthy, 60 COPD) in a previous study. Healthy cohorts included Young (20–32 years) and Elderly (64–85
years) patients. COPD patients were divided into those with expiratory flow limitation (FL) and those without
(NFL). Inspiratory R was treated as linear (R1,insp). Expiratory R was modelled with two separate models for a
comparison: linear with constant resistance (R1,exp), and nonlinear time-varying resistance (R2,exp(t)) using bsplines.
Results: Model fit to PQ loops show inspiration is typically linear. Linear R1,exp captured expiratory dynamics in
healthy cohorts (RMSE 0.3 [0.2 - 0.4] cmH2O), but did not capture nonlinearity in COPD patients. COPD cohorts
showed PQ-loop ballooning during expiration, which was better captured by non-linear R2,exp(t) (RMSE 1.7
[1.3–2.8] vs. 0.3[0.2–0.4] cmH2O in FL patients). Airway resistance is higher in COPD than healthy cohorts
(mean R2,exp(t) for Young (1.9 [1.6–2.8]), Elderly (2.4 [1.4–3.5]), NFL (4.9 [3.9–6.6]) and FL (13.5 [10.4–21.9])
cmH2O/L/s, with p ≤ 0.0001 between aggregated measures for Young and Elderly healthy subjects and NFL and
FL COPD subjects). FL patients showed non-linear R2,exp(t) dynamics during flow deceleration, differentiating
them from NFL COPD patients.
Conclusions: Linear model metrics describe expiration dynamics well in healthy subjects, but fail to capture
nonlinear dynamics in COPD patients. Overall, the model-based method presented shows promise in detecting
expiratory flow limitation, as well as describing different dynamics in healthy, COPD, and FL COPD patients. This
method may thus be clinically useful in the diagnosis or monitoring of COPD patients using Plethysmography
data, without the need for additional expiratory flow limitation confirmation procedure
Cytogenetics of chronic myeloid leukaemia
No full textThe standard Philadelphia (Ph) translocation t(9;22), its variants and a proportion of Ph-negative cases are positive for the BCR-ABL fusion gene, as determined by molecular analysis. Extensive deletions of chromosome 9 and 22 derived sequences around the translocation breakpoints on the derivative 9 are seen in 10–30% of patients at diagnosis and may confer a worse prognosis. Additional cytogenetic changes can occur in the few months before or during disease progression and are often specific for blast morphology; however, the molecular basis of the most common additional cytogenetic abnormalities is largely unknown. Cytogenetics is important for monitoring patient response to treatment but is increasingly being replaced by the more sensitive and less invasive techniques of RT-PCR and FISH
Utilization of spent black ash from the soda pulp process
No full textThesis (B.S.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1922.Includes bibliographical references (leaf 24).by Fred Chase Koch.B.S
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