1,721,119 research outputs found
Rischi e benefici della terapia con antiepilettici
No full textAntiepileptic therapies can give rise to toxic problems. AED toxicity can be classified into idiosyncratic reactions, dose-dependent side effects, dose-independent side-effects. Furthermore adverse effects during pregnancy have to be taken into account. The AA reviewed the indications of AED and special situations where risks linked with an antiepileptic therapy might be more troublesome than rare epileptic seizures
Monoterapia e politerapia nelle epilessie farmacoresistenti
No full textMonotherapy is certainly the best choice for the treatment of all types of epilepsy. In severe epilepsies, when one-drug treatments do not obtain seizure control, a second drug is generally used in order to reach a best clinical outcome, but the real advantage of polytherapy versus monotherapy is still not known in these cases. A retrospective survey was carried out on 66 adult patients with different types of epilepsy who had taken two-drug therapy after failure of the initial monotherapy. With polytherapy, only 16.5% of cases showed a reduction in seizure frequency of 75%, 67% showed no modification and in another 16.5% an increase in seizure frequency of 100% was observed. Polytherapy seems to be not more effective of monotherapy in severe epilepsies in order to obtain a best clinical outcome
Worsening in seizure frequency and severity in relation to folic acid administration
No full textWe report a case of increase in seizure frequency and severity in a 26-year-old woman receiving folic acid at a dosage of 0.8 mg/day. She had symptomatic partial epilepsy with simple and complex seizures treated with carbamazepine. She was planning pregnancy and we prescribed folic acid for prevention of neural-tube defects. In the next few days she had a generalized tonic-clonic seizure for the first time and a significant increase in seizure frequency. Because of the temporal relation between the seizure worsening and the administration of folic acid, we hypothesize a role of folic acid in provoking seizures, as has been reported in the literature
Biodisponibilità e tollerabilità di due differenti formulazioni galeniche di carbamazepina
No full text
Elderly people and epilepsy : cognitive function
No full textPURPOSE: To evaluate cognitive function in a group of elderly patients with focal epilepsy versus healthy controls. METHODS: A neuropsychological battery assessing major cognitive domains was administered to 40 patients with focal epilepsy aged > or = 60 years, and to 40 controls matched for sex, age, and education. RESULTS: Epilepsy patients performed significantly worse in most of the administered tests than controls (p < 0.05). Poor cognitive performances correlated with use of polytherapy. CONCLUSIONS: Given the high prevalence of epilepsy in the elderly, our results could have important implications for clinical and research purpose
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