1,850 research outputs found
Slow continuous intracorporeal plasmapheresis for acute fluid overload
No full textIntermittent dialysis is still the predominant treatment for acute or chronic renal insufficiency in the USA despite increasing evidence that slower and longer fluid management therapies are more beneficial to the patient. We have investigated the use of slow continuous intracorporeal plasmapheresis (SCIP) as a more efficient and hemodynamically stable alternative means of treating acute fluid overload. In this paper we discuss preliminary observations on the safety of SCIP catheter insertion, fluid removal, extraction and pathology in Yorkshire pigs. SCIP catheters removed plasma for extracorporeal plasma water removal without significant gross or histopathological changes. Blood chemistry and cell counts remained stable during therapy. Toxicological studies indicated no pyrogenicity, hemolysis, cytotoxicity, acute systemic toxicity, delayed-type hypersensitivity, or blood recalcification coagulation inhibition. Intracutaneous extracts caused only mild irritation. SCIP therapy appears to be safe for use in the removal of plasma and plasma water from experimental animals. Copyright (C) 2003 S. Karger AG, Basel
Intravenous catheter for intracorporeal plasma filtration
No full textFuture advances in dialysis of end-stage renal disease patients may include improvements in therapeutic continuity and patient mobility. Continuous renal replacement therapies could lead to self-contained, mobile and potentially wearable dialysis units. We investigated an experimental, intravenous slow-continuous plasma separation system (IPSS) as a precursor to direct intravenous hemofiltration. An intracorporeal catheter employs asymmetric hollow fibers to separate blood cells from plasma in vivo. The fibers possess a sieving coefficient of 0.7 mum and remove 99.99% of all platelets. In vivo, catheters sustain an average plasma separation flow rate of 3 ml/min over 22 h, sufficient to remove 2 net liters of water from pigs through an extracorporeal hemofilter. Used catheter fibers are relatively free of protein deposition or clots in situ. In vitro studies suggest that human catheters may perform at 3-4 times the rate of porcine catheters. IPSS is proposed for acute fluid removal in CHF patients refractory to diuretics. Copyright (C) 2002 S. Karger AG, Basel
The colonial ascidian fauna of Fiordland, New Zealand, with a description of two new species
No full textFigure 4. Botrylloides leachii (NIWA 4998): (A) Zooid; (B1, B2) parietal and mesial sides of the stomach; (C) ventral side of a zooid showing relative position of gonads. Scale bars: A, C 1 mm; B 0.5 mm.Published as part of Page, M.J., Willis, T.J. & Handley, S.J., 2014, The colonial ascidian fauna of Fiordland, New Zealand, with a description of two new species, pp. 1653-1688 in Journal of Natural History (J. Nat. Hist.) 48 (27-28) on page 1659, DOI: 10.1080/00222933.2014.896487, http://zenodo.org/record/519387
Novel approach to the treatment of chronic fluid overload with a new plasma separation device
No full textMany patients with congestive heart failure suffer at some point in their therapy from severe fluid overload, and a significant proportion of patients become unresponsive to diuretic drug therapy. In this paper, we propose a new experimental approach to plasma purification and the treatment of severe fluid overload in acute care patients. Plasma can be extracted directly from the patient through an intracorporeal catheter temporarily placed within the inferior vena cava. Plasma separation is accomplished through a proprietary membrane placed on the tip of the catheter. A simple circuit performs plasma removal. The extracted plasma is then available for any type of treatment before being returned to the patient via a second lumen in the same catheter. Plasma flow rates between 3 and 8 ml/min have been achieved and animal tests led to the removal of more than 2,000 ml of plasma water in 24 h. The current varieties of blood purification or ultrafiltration techniques employ extracorporeal extraction of blood from the patient in order to perform treatment. Removal of the cellular component in the extracorporeal fluid circuit may reduce the current problems associated with extracorporeal circuits, such as cellular lysis and viscosity-related problems. Plasma treatment is already successfully performed in a variety of therapies, including renal replacement therapies and plasmapheresis. The therapy proposed here may extend the utility of plasma treatment to the acute cardiology patient. The system could become an important complementary therapy for patients with congestive heart failure for whom classic methods of treatment have failed or simply are not available. Copyright (C) 2002 S. Karger AG, Basel
Chiroderma gorgasi Handley 1960
No full textChiroderma gorgasi Handley, 1960 Synonyms: Chiroderma gorgasi Handley, 1960: 464; type locality “ Tacarcuna Village, 3,200 ft., Río Pucro, Darién, Panama.” Chiroderma trinitatum gorgasi: Barriga-Bonilla, 1965: 246; name combination. Type Material. The type of C. gorgasi, USNM 309903, consists of a stuffed skin, skull and mandible, collected in Tacarcuna Village, Panamá, on March 6, 1959 by C. O. Handley and B. R. Feinstein (field number COHJR 5436). It is an adult male, captured in a mist net over water. The skin is in good condition with the facial and dorsal stripes observable in the specimen. The skull and mandible are in good condition and every tooth is present. The I1 have convergent tips. Distribution and Habitat. Specimens are known from Panamá, western Colombia, and northwestern Ecuador (Fig. 23), and there is a record from eastern Honduras (Turcios-Casco et al. 2020). The unconfirmed record for Costa Rica is based on a bat captured and released by R. LaVal in Tortuguero (Timm & LaVal 1998). Also in Costa Rica, Harvey & González-Villalobos (2007) reported the capture of 18 “ Chiroderma trinitatum ” in Talamanca, but we could not verify if there are voucher specimens to support this claim. The occurrence of the species in Costa Rica is expected, as C. gorgasi has been recorded in western Panamá and eastern Honduras (Handley 1966b; Turcios- Casco et al. 2020). The records of C. gorgasi are from the humid forests of the Chocó of Colombia, the Darién of Panamá, Caribbe- an lowland forests of Honduras, and montane forests of the Rio Magdalena valley in Colombia. The altitude where specimens have been obtained ranges from 30 m in Esmeraldas, Ecuador, to 975 m, in Tacarcuna, Panamá. There are Colombian records of the species occurring at 2,100 in Tolima and between 1,600 and 2,300 m in Risaralda (Galindo-Espinosa et al. 2010; Castaño et al. 2018). Description and Comparisons. Dorsal pelage may vary from pale to dark brown. Individual hairs of the dorsum are tricolored: the base is approximately ¼ of the hair length and dark brown, the middle band is approximately ½ of the length of the hair and varies from buff to pale gray, and the tip is about ¼ of the hair length and varies from pale to dark brown. Both pairs of facial stripes are conspicuous. The dorsal stripe is conspicuous in approximately half of the sample (47%, n=8); whereas, it is barely visible in nine specimens. The ear margins and base are paler than the remainder of the ear conch. The noseleaf has a simple tip, is brown in color, with pale margins on the horseshoe. Dimensions of the skull are similar to those of C. trinitatum, and the two species are the smallest Chiroderma (Tables 7 and 8). Braincase is globose, clearly distinguishable in profile from the frontonasal region. The sagittal crest is poorly developed and was not detected in 9 of the 17 specimens we scored for this character. The nasal notch is short and either does not reach the interorbital region, or extends only the level of the anterior border of the orbit. Similar to C. trinitatum, the post-orbital processes are rhomboid and not pointed as in the other Chiroderma. The posterior palatine process was absent in 13 of 15 specimens and in the other 2, the process was only a small bump. When cranium and mandible are in occlusion, a lateral gap is visible, bordered by C, P3, P4, p2 and p4. The I1s are convergent and their tips are usually in contact. The mandibular condyle is level with or slightly below the toothrow. The lower canines are relatively narrow and high-crowned, with the crown tip level with the top of the coronoid process, when viewed laterally. The p2 is in contact with c, but not with p4, or if not in contact with the lower canine, p2 may be either closer to the lower canine or equidistant from c and p4. The p2 usually is longer mesiodistally than high and the protoconid is shifted anteriorly, not aligned with the base of the tooth when viewed laterally (Fig. 27). Chiroderma gorgasi differs from every other Chiroderma, except C. trinitatum, by its smaller size and nasal notch usually not reaching the interorbital region. Comparisons with C. trinitatum were made in the previous section. Geographic Variation and Phylogeography. Sequences of three individuals of C. gorgasi were analyzed in the phylogeny, precluding making inferences on geographical structuring. Within-species variation was 1.04%, the second highest value in Chiroderma after C. villosum (1.17%). Subspecies. C. gorgasi is monotypic. Remarks. Handley (1960) described Chiroderma gorgasi based on five specimens from Panamá and one C. trinitatum from Trinidad, the type and only known specimen at the time. In the original description, Handley (1960: 465) suggested that, as the sample size increased, the two taxa could prove to be conspecific. Shortly after its description, C. gorgasi was treated as a subspecies of C. trinitatum, based on their morphological similarity (Barriga- Bonilla 1965; Jones & Carter 1976; Hall 1981). Simmons (2005) recognized a monotypic trinitatum with gorgasi as a junior synonym. Recently, Lim et al. (2020) recognized C. gorgasi as a distinct species, because it does not share a most recent common ancestor with C. trinitatum, and has distinguishing morphological characters. Natural History. C. gorgasi is a frugivore, specialized on fruits of Ficus (Bonaccorso 1979). Four species of fruits and infructescences have been recorded in the diet of C. gorgasi: Ficus popenoei, Piper aduncum, Solanum umbellatum, and Vismia sp. (Bonaccorso 1979; Castaño et al. 2018). The vertical distribution suggests that C. gorgasi is a canopy and sub-canopy frugivore, more frequently captured in nets between 3 and 12 m above ground (Bonaccorso 1979). The few reproductive data for the species suggest a pattern of seasonal polyestry. A pregnant female was captured in June in Colombia and lactating individuals were recorded in February and March in Panamá. Literature data for Panamá report pregnancies in February, May and between September and November; whereas lactating females are documented from May and September (Fleming 1973; Bonaccorso 1979). Births apparently occur toward the end of the dry season, between February and May, and in the middle of the rainy season, between July and September, when fruits are most abundant. Specimens Examined (N = 18): Colombia: Antioquia, La Tirana (IAvH-M 917, 934, 974, USNM 499475, 499477, 499479); Chocó, Corregimiento Gilgal (IAvH-M 4932), Finca El Recurso (IAvH-M 3260, 3299, 3323); Valle del Cauca, Río Zabaletas (USNM 483764). Panamá: Darién, Parque Nacional Darién (ROM 104342), Tacarcuna Village Camp (USNM 309902, 309903 [holotype of gorgasi], 309904); San Blas, Armila (USNM 335294, 335296, 335297).Published as part of Garbino, Guilherme S. T., Lim, Burton K. & Tavares, Valéria Da C., 2020, Systematics of big-eyed bats, genus Chiroderma Peters, 1860 (Chiroptera: Phyllostomidae), pp. 1-93 in Zootaxa 4846 (1) on pages 44-45, DOI: 10.11646/zootaxa.4846.1.1, http://zenodo.org/record/401749
Slow continuous intravenous plasmapheresis (SCIPTM): Clinical applications and hemostability of extracorporeal ultrafiltration
No full textAn intravenous plasmapheresis catheter which excludes > 99.4% of platelets from external ultrafiltration circuits is currently undergoing safety and efficacy trials for fluid removal from NYHA class II-IV congestive heart failure patients resistant to diuretic drug therapy. In animals, the SCIPTM catheter allowed a four fold increase in ultrafiltration efficiency without hemolysis, hermoinstability or external cartridge changes in 72 hours of treatment. Further, systemic anticoagulation was not required. These techniques might be envisioned for treatment of fluid overload in heart failure, surgery or trauma and may have applications in therapeutic apheresis, venous thrombosis, liver disease or autologous tissue engineering. Copyright (c) 2005 S, Karger AG. Hasel
Slow continuous intracorporeal plasmapheresis (SCIP) for the treatment of acute fluid overload
No full text
6. The Oxyrhynchus Papyri vol. L. Edited with translations and notes by A. K. Bowman, H. M. Cockle, W. E. H. Cockle, R. A. Coles, Ε. W. Handley, M. W. Haslam, E. Lobel, H. Maehler, P. J. Parsons, T. S. Pattie, J. R. Rea, C. H. Roberts, J. L. Rowlandson, T. C. Skeat, J. D. Thomas, E. G. Turner, J. E. G. Whitehorne (Graeco-Roman Memoirs, No. 70)
No full textIrigoin Jean. 6. The Oxyrhynchus Papyri vol. L. Edited with translations and notes by A. K. Bowman, H. M. Cockle, W. E. H. Cockle, R. A. Coles, Ε. W. Handley, M. W. Haslam, E. Lobel, H. Maehler, P. J. Parsons, T. S. Pattie, J. R. Rea, C. H. Roberts, J. L. Rowlandson, T. C. Skeat, J. D. Thomas, E. G. Turner, J. E. G. Whitehorne (Graeco-Roman Memoirs, No. 70). In: Revue des Études Grecques, tome 97, fascicule 462-464, Juillet-décembre 1984. pp. 555-556
6. The Oxyrhynchus Papyri vol. L. Edited with translations and notes by A. K. Bowman, H. M. Cockle, W. E. H. Cockle, R. A. Coles, Ε. W. Handley, M. W. Haslam, E. Lobel, H. Maehler, P. J. Parsons, T. S. Pattie, J. R. Rea, C. H. Roberts, J. L. Rowlandson, T. C. Skeat, J. D. Thomas, E. G. Turner, J. E. G. Whitehorne (Graeco-Roman Memoirs, No. 70)
No full textIrigoin Jean. 6. The Oxyrhynchus Papyri vol. L. Edited with translations and notes by A. K. Bowman, H. M. Cockle, W. E. H. Cockle, R. A. Coles, Ε. W. Handley, M. W. Haslam, E. Lobel, H. Maehler, P. J. Parsons, T. S. Pattie, J. R. Rea, C. H. Roberts, J. L. Rowlandson, T. C. Skeat, J. D. Thomas, E. G. Turner, J. E. G. Whitehorne (Graeco-Roman Memoirs, No. 70). In: Revue des Études Grecques, tome 97, fascicule 462-464, Juillet-décembre 1984. pp. 555-556
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