38 research outputs found
review of R. Carter Investigating English Discourse. Language, Literacy, Literature. Routledge 1997
No full textrecensione di R. Carter, “Investigating English Discourse. Language, Literacy, Literature” in EJES (European Journal of English Studies) vol.4, n.3, pp. 335-337. ISSN 1382 5587
No full textAcute dose-response curve of enalapril in renovascular hypertensives
No full textWe evaluated the acute blood pressure lowering effect of enalapril in terms of dose-response curve and compared this effect with that on humoral parameters. Eleven renovascular patients with acute angiotensin-converting enzyme (ACE) inhibition received (according to a randomized double-blind cross-over design) placebo, 10, 20, and 40 mg of enalapril with a 72-hour interval between each dose. Seated blood pressure and heart rate were measured every hour for 6 hours and then again at the twelfth and twenty-fourth hour, while venous blood samples for plasma renin activity, plasma aldosterone and serum ACE measurements were obtained at the fourth and twenty-fourth hour after receiving the placebo or drug. Blood pressure was significantly reduced by all three doses of enalapril at hour 4, while at hour 24 it was reduced only by the 20- and 40-mg doses. A significant correlation (r = 0.68; P less than 0.001) was found between percentage decrements of mean blood pressure and the log of the doses at hour 4 with a similar (although not significant) trend at hour 24. Plasma renin activity was significantly and to a similar extent increased by the three doses of enalapril at hour 4, while at hour 24 it was significantly increased only by the 40-mg dose. Serum ACE and plasma aldosterone were significantly reduced both at hours 4 and 24 without any difference between doses. No correlation was found between mean blood pressure changes and those of humoral factors.(ABSTRACT TRUNCATED AT 250 WORDS
“A special dictionary of phraseology: Duverger’s comparison between the Idioms, Genius and Phraseology of the French and English Languages (1810?)”,
No full textWilliam Duverger’s “Comparison between the Idioms, Genius and Phraseology of the French and the English languages” (1810?) is an interesting ‘pedagogical’ dictionary of ‘phraseology’ for encoding purposes addressed to English-speaking young ladies. It records English phraseological expressions and their equivalents in French. The author sets himself the task of showing “avec quels autres mots il [chaque mot] peut être placé”. The term ‘phraseology’ is indeed used in a rather ‘modern’ linguistic and lexicographic sense, since it refers to both grammatical and lexical collocations: for example “to be blind to”, “être aveugle où dans l’aveuglement sur”, as opposed to “to be blinded with, être aveuglé par”; or “an assuming blockhead”, “un sot plein d’orgueil et d’affectation”.
The paper will illustrate the characteristics of this dictionary, with references to other lexicographical works and to French teaching methodology in early nineteenth century England
Reading The Book of Margery Kempe in the 21st Century: Gender, Authorship, and Performance
No full textThe history of The Book of Margery Kempe, written at the beginning of the 15th century by a burgess of Bishop's Lynn (Norfolk), is quite revealing of the way Medieval Studies have entered the 21th century.
Its links with the present have become stronger thanks to the critical approach, first of Women's Studies and then of Gender Studies (see Partner 1993; and also Bennett 1993), to the issues of authorship, sexuality and the body, and ultimately of performance Hopenwasser 1999; Bradford 2001; McAvoy 2005
Vancomycin-Resistant Enterococcus faecium (VRE) Bacteremia in Infective Endocarditis Successfully Treated with Combination Daptomycin and Tigecycline
No full textCoronary Artery By-Pass Grafting in Patient With Paroxysmal Nocturnal Hemoglobinuria (Case Report)
Get PDFParoxysmal nocturnal haemoglobinuria (PNH) is a clonal haematopoietic stem cell disease that presents with haemolytic anaemia, thrombosis and bone marrow failure. We report a case of a 51-year-old male with a history of PNH in treatment with Eculizumab admitted to our Hospital for acute chest pain and dyspnoea. The diagnosis was a triple vessel disease and patient was scheduled for coronary artery bypass grafting surgery. To balance the risk between thrombosis and bleeding in this particular clinical setting, we decided to use thromboelastography (TEG) as point of care solution and we used the R parameter as the target of our anticoagulant therapy. The R parameter between 11 and 14 sec can be used as a target value to balance the risk; in addition, there was no evidence of acute hemolysis during the surgery and supplemental dose of Eculizumab was administered in order to minimize any potential exacerbation of intravascular hemolysis
AGGRESSIVE APPROACH WITH BORTEZOMIB AND CYCLOPHOSFAMIDE, FOLLOWED BY AUTOLOGOUS STEM CELL TRANSPLANTATION (ASCT) AND THALIDOMIDE CONSOLIDATION, IS FEASIBLE IN OLDER PATIENTS WITH MULTIPLE MYELOMA AND CAN ACHIEVE A MYELOMA-FREE HARVEST
No full textExpression of ABCC6 gene in Acute Myeloid Leukemia
No full textMultidrug resistance (MDR) is a major impediment to the successful treatment of acute myeloid leukemia (AML). One of the known MDR mechanisms is the over expression of efflux pumps belonging to the superfamily of ABC transporters, such as P-glycoprotein (ABCB1), BCRP (ABCG2) and MRP1 (ABCC1) [1].
At present, little is known about the clinical relevance of other ABC-transporters in AML. However it was observed that patients with acute lymphoblastic leukemia presenting high MRPs expression, including MRP6, have unfavorable prognosis [2].
In this study, we investigated the expression of ABCB1, ABCC1, ABCG2 and ABCC6 genes in six healthy controls and in thirteen patients with AML, at diagnosis, after chemotherapy, at refractory disease and at relapse. Real-time PCR results showed that at diagnosis, compared to healthy subjects, all patients, except one, presented at least one among ABCB1/ABCC1/ABCC6 genes up-regulated; instead ABCG2 was always down-regulated. Moreover, we interestingly observed that three patients with poor prognosis exhibited higher level of ABCC6 mRNA after treatment compared to diagnosis and that in these patients also BCRP was up-regulated, sign of chemoresistance. We also observed that ninety percent of treated patients presented ABCG2 expression significantly higher after treatment than at diagnosis; thirty percent presented over expression of ABCB1 and only two patients showed ABCC1 up-regulation.
In conclusion, our results showed a possible involvement of MRP6 in the development of MDR in AML and that BCRP has, more than MDR1 and MRP1, a relevant role in this mechanism.
ABCC6 resulted up-regulated in thirty percent of treated AML patients, but further studies on a larger number of patients are necessary to establish if MRP6 may be involved in the treatment failure of AML and if co-expression of these ABC-transporters may have prognostic significance.
REFERENCES
1. Brian C. Shaffer et al. Drug Resist Updat. 2012; 15(1-2): 62–69.
2. Plasschaert SL et al. Clin Cancer Res. 2005; 15;11(24 Pt 1):8661-8
