364 research outputs found
Design of Linear and Planar Arrays with Low Sidelobe Levels and High Directivity Using Two-way Array Factor
No full textSidelobes in the two-way radiation pattern are of serious concern in a radar array. Several techniques have evolved to mitigate the problem, which include amplitude tapering, Genetic Algorithm (GA) optimization, thinning transceiver aperture, and two-weight amplitude distribution. With such optimization schemes, the sidelobes can be considerably suppressed but at the cost of a reduction in directivity or taper efficiency. Further, such amplitude tapers require a complex feeding network design. This work alleviates such design restrictions and proposes a systematic approach to lower the sidelobes in radar two-way shared aperture arrays. The proposed methodology can achieve a sidelobe level (SLL) of below -52 dB in both linear and planar arrays, which is about 18 dB enhancement in SLL compared with uniform transmit and thinned receive arrays. In addition, as a result of the equal transceiver array size in the proposed design, an improvement of approximately 0.44 dB and 0.68 dB in directivity is achieved in linear and planar arrays, respectively. A novel feeding architecture is also illustrated to reduce the cost and complexity of the overall feeding network. A set of full-wave simulations have also been performed to validate the theoretical results
Google_Harvard_Fibroblast_SMA_supplementary_6-20-2019 – Supplemental material for Applying Deep Neural Network Analysis to High-Content Image-Based Assays
No full textSupplemental material, Google_Harvard_Fibroblast_SMA_supplementary_6-20-2019 for Applying Deep Neural Network Analysis to High-Content Image-Based Assays by Samuel J. Yang, Scott L. Lipnick, Nina R. Makhortova, Subhashini Venugopalan, Minjie Fan, Zan Armstrong, Thorsten M. Schlaeger, Liyong Deng, Wendy K. Chung, Liadan O’Callaghan, Anton Geraschenko, Dosh Whye, Marc Berndl, Jon Hazard, Brian Williams, Arunachalam Narayanaswamy, D. Michael Ando, Philip Nelson and Lee L. Rubin in SLAS Discovery</p
A note on assosymmetric rings
No full textIn this paper, first commutators lie in the nucleus will be established. Later it will be proved that in a 2-and 3-divisible prime assosymmetric ring , commutators also lie in center and hence is associative.</jats:p
Effect of Freeze Drying on the Stability of Probiotic Lactic Acid Bacteria
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
Translating evidence into practice in low resource settings: cervical cancer screening tests are only part of the solution in rural India
No full textBACKGROUND: The majority of women in rural India have poor or no access to cervical cancer screening services, although one.quarter of all cervical cancers in the world occur there. Several large trials have proven the efficacy of low-tech cervical cancer screening methods in the Indian context but none have documented the necessary components and processes of implementing this evidence in a low-resource setting. METHODS: This paper discusses a feasible model of implementation of cervical cancer screening programme in low-resource settings developed through a pilot research project carried out in rural Tamilnadu, India. The programme used visual inspection of cervix after acetic acid application (VIA) as a screening tool, nurses in the primary care centres as the primary screeners and peer educators within Self-Help Women groups to raise community awareness. RESULTS: The uptake of screening was initially low despite the access to a screening programme. However, the programme witnessed an incremental increase in the number of women accessing screening with increasing community awareness. CONCLUSIONS: The investigators recommend 4 key components to programme implementation in low-resource setting: 1) Evidence-based, cost-effective test and treatment available within the reach of the community; 2) Appropriate referral pathways; 3) Skilled health workers and necessary equipment; and 4) Optimisation of health literacy, beliefs, attitudes of the community.Rita Isaac, Madelon Finkel, Ian Olver, I.K. Annie, H.R. Prashanth, J. Subhashini, P.N. Viswanathan and Lyndal J. Treven
A Study to Evaluate the Association of Biomarkers with Pulmonary Capillary Wedge Pressure and Plasma Concentration of the Inotrope Dobutamine in Patients Undergoing On-Pump CABG Surgery in a Superspeciality Hospital at Coimbatore: A Prospective Observational study
No full textBACKGROUND: On-Pump Coronary Artery Bypass Grafting (CABG) is considered the gold standard surgical revascularization procedure. On-Pump CABG surgery uses a Cardio-Pulmonary Bypass machine that enables the entire cardiac output to circumvent the patient's heart and lungs. The intra-operative Pulmonary Capillary Wedge Pressure (PCWP) reflects Left ventricular End Diastolic Volume, which is increased in case of left ventricular systolic dysfunction. Such a dysfunction demands judicious use of inotropes to improve myocardial contractility. The cardiac biomarker NT-Pro BNP is an acknowledged marker of Left Ventricular Systolic dysfunction that results in Low Cardiac Output Syndrome (LCOS). The inotrope that is commonly used to tackle a LCOS is Dobutamine. Cardio Pulmonary Bypass machine employed during an On-Pump CABG surgery elicits a Systemic Inflammatory Response Syndrome (SIRS) with the production of various inflammatory cytokines which are known to influence the pharmacokinetics of various drugs administered during the course of the procedure.
AIM OF THE STUDY:
To investigate the role of a cardiac biomarker NT-Pro BNP and an inflammatory marker TNF-α on the Pulmonary Capillary Wedge Pressure (PCWP) and the plasma concentration of the inotrope dobutamine in patients undergoing On-Pump CABG surgery.
OBJECTIVES:
1. To evaluate if the preoperative level of the cardiac biomarker NT-Pro BNP, correlates with intraoperatively measured Pulmonary Capillary Wedge Pressure (PCWP) in patients undergoing On-Pump CABG surgery.
2. To evaluate the role of the inflammatory mediator TNF alpha on the intraoperative plasma concentration of Dobutamine.
3. To evaluate the association of NT-pro BNP and TNF-α with existing comorbidities.
MATERIALS AND METHOD:
Between July 2018 and June 2019, 44 patients who underwent On-Pump CABG surgery in the department of CTVS at PSG hospitals were included in the study. About 4ml of venous blood sample was collected in the preoperative period and centrifuged to separate plasma, in which Plasma NT-Pro BNP and Plasma TNF alpha was estimated using respective ELISA kits. During surgery hemodynamic parameters including PCWP was collected from the anaesthetist. Fourth hour from incision, 4ml of venous blood sample was collected and centrifuged to separate plasma, in which Plasma TNF alpha was measured using ELISA kit and Plasma concentration of Dobutamine at steady state was estimated using HPLC.
RESULTS:
Results revealed that a strong positive linear relationship existed between pre-operative NT-Pro BNP and PCWP (r= 0.821**;p 0.05 and there was no significant difference in the level of NT Pro BNP and TNFα among participants with and without the co-morbidities (P>0.05).
CONCLUSION:
The present study highlights the importance of estimating Preoperative NT-pro BNP that could serve as a valuable marker in predicting intraoperative risk of developing LCOS with elevated PCWP in patients undergoing on-pump CABG surgery and aid anaesthetists and surgeons in decision making prior to surgery. The influence of TNF-alpha on dobutamine concertation at steady state requires further investigation in large scale prospective studies
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