127 research outputs found
Dalle teorie ingenue all'approccio scientifico: interazione tra pari e cambiamento concettuale
No full textA study on sequential minimal optimization methods for standard quadratic problems
No full textIn this work, we consider the relevant class of Standard Quadratic Programming problems and we propose a simple and quick decomposition algorithm, which sequentially updates, at each iteration, two variables chosen by a suitable selection rule. The main features of the algorithm are the following: (1) the two variables are updated by solving a subproblem that, although nonconvex, can be analytically solved; (2) the adopted selection rule guarantees convergence towards stationary points of the problem. Then, the proposed Sequential Minimal Optimization algorithm, which optimizes the smallest possible sub-problem at each step, can be used as efficient local solver within a global optimization strategy. We performed extensive computational experiments and the obtained results show that the proposed decomposition algorithm, equipped with a simple multi-start strategy, is a valuable alternative to the state-of-the-art algorithms for Standard Quadratic Optimization Problems
Come dipingeva il Caravaggio, Atti della giornata di studio (Firenze, Aula Magna dell’Università degli Studi, 28 gennaio 1992)
No full textSynthesis and pharmacological activity of 1-phenyl-2-oxa-5-azabicyclo[4.4.0]decane derivatives
No full textTitle compds. I (Z = O, H2; R = H, Me) and II were prepd., and they showed central nervous system stimulant and anticonvulsant activity. Thus, a 2-aminocyclohexanol deriv. was treated with ClCH2COCl and NaOH to give amide III, and III and KOCMe3 in C6H6 were kept at room temp. to give I (Z = O, R = H)
Energy efficiency improvements in italian historical buildings: The case study of Ascoli Piceno
No full textEvaluating the energy efficiency of historical buildings is an important theme nowadays, with European directives that fix a strong reduction in energy use and impose an increase in the amount of energy produced by renewable sources. Within restoration and other related disciplines, it is therefore necessary that a specific method of investigation for historical buildings be developed. The methodological approach of energy efficiency in historical buildings, from the building scale to the urban scale, must account for the particular characteristics of historical buildings. Each operation should be carefully examined in each case and defined within a grid of possible interventions that can combine conservation and innovation. Public administrations have also recently addressed these themes to evaluate medium and long-term strategies useful in more effectively managing the heritage. These objectives form the basis for recent research involving the city of Ascoli Piceno. The aim is to provide the entities that manage the cultural heritage with criteria and methods to completely and critically assess historical buildings while also duly considering aspects related to their energy performance
Chemistry of the Dihydrothiazine Ring Moiety of Cephalosporins. A Route to 3-Formoxymethyl-3-Cephem Derivatives
No full textBromination of cepham I with 2,6-lutidine Br complex gave II (R = Br), which was treated with DMF/H2O to give II (R = OCHO)
Energy efficiency improvements in italian historical buildings: The case study of Ascoli Piceno
No full textEvaluating the energy efficiency of historical buildings is an important theme nowadays, with European directives that fix a strong reduction in energy use and impose an increase in the amount of energy produced by renewable sources. Within restoration and other related disciplines, it is therefore necessary that a specific method of investigation for historical buildings be developed. The methodological approach of energy efficiency in historical buildings, from the building scale to the urban scale, must account for the particular characteristics of historical buildings. Each operation should be carefully examined in each case and defined within a grid of possible interventions that can combine conservation and innovation. Public administrations have also recently addressed these themes to evaluate medium and long-term strategies useful in more effectively managing the heritage. These objectives form the basis for recent research involving the city of Ascoli Piceno. The aim is to provide the entities that manage the cultural heritage with criteria and methods to completely and critically assess historical buildings while also duly considering aspects related to their energy performance
Conformational effects on the activity of drugs. 7. Synthesis and pharmacological properties of 2-(p-nitrophenyl)-substituted morpholines
No full textA series of l-@-nitrophenyl)-2-aminoethanold erivatives and their morpholine analogues have been synthesized and
pharmacologically investigated in order to confirm some pharmacological observations made with the N-isopropyl-
substituted compounds. In agreement with the previously obtained results, the weak a-adrenergic-stimulating
activity and the potentiating effect on the responses to norepinephrine found in the open-chain compounds persist
in their corresponding semirigid cyclic analogues. The results are discussed in the light of common knowledge of
the structure-activity relationships of a-adrenergic drugs
Investigation of split-electrode configurations for High-Power diffusion cooled anular CO2 lasers,
No full textFor a kW annular diffusion-cooled laser, we tested the possibility of using the electrodes directly as waveguide wall. We considered dielectric and metallic spacers. Electric field distribution calculations and preliminary experimental results are presented
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