36 research outputs found
The importance of presynaptic beta receptors in Raynaud's disease
No full textAbstract
The purpose of the present study was to investigate the effect of atenolol, a β1-selective blocker, along with flunarizine, a calcium antagonist, in the management of Raynaud's disease. Forty patients with Raynaud's disease were randomized into a trial in which atenolol (50 mg daily) was given with flunarizine (10 mg daily). During the trial all patients were subjected to finger photoplethysmography and were given a diary to note daily the number and duration of the crises and presence or absence of pain and paresthesia. The association of atenolol with flunarizine caused an 80% reduction in the number of vasospastic crises, a significant increase (p < 0.001) in the photoplethysmographic wave amplitude, and complete disappearance of pain and paresthesia. These results were not observed in patients treated with a placebo. Flunarizine reinforces the action of atenolol in causing a decrease in vasoconstriction in patients with Raynaud's disease, as observed previously by us, in that it acts directly on the β-presynaptic receptors or on the calcium slow channels connected to the β-receptors. The present study confirms that the principal role in the physiopathologic progression of Raynaud's disease seems to be played by a modification of the β-presynaptic receptors in the nerve endings of the peripheral vessels
Difficulties in reading and neuropsychological profile on WISC-IVin Italian children
No full textSince the born of intelligence tests, there have been a debate about the praticai use of intelligence tests, also with a lots of critics about the nature and the data we can derive from them. Perhaps the study of intelligence tests could be divided in different historical steps, in newer steps intelligence test were used and analyzed according to more detailed psychometrical bases and aiming to define specific profiles and to design specific intervention according to thus specific profiles. In current step, the single general index IQ is maintained but there is also a deeper analysis of single indexes and macroindexes according to a theorical framework. Wechsler Intelligence Scales are one of the worldwide more utilized tests for the assessment of general reasoning abilities and cognitive profile in children. In the last 20 years the CHC Model from Cattell-Horn and Carrol is the worldwide more utilized theoretical model for the analysis of abilities related to intelligence and pattern derived from intelligence test, supported by a great number of datasets. The interpretation of WISC-IV scores, based on CHC (Carrol-Horn-Cattell) model of intelligence, permit to evaluate single cognitive functions and to assess general reasoning competence as well as to describe verbal reasoning, visual spatial reasoning, working memory and speed of processing. New diagnostic criteria for dyslexia and for specific learning disabilities on reading from DSM-5 no more considered discrepancy criteria (a discrepancy between IQ and scores on reading test), but the assessment of neuropsychological profile and cognitive profile by intelligence test and other neuropsychological tests of the child remains an important phase of clinical evaluation ((1), (2), (3)). Different studies analyzed performance on WISC test in children with reading disorders from different countries (for example in France and Portugal), using different versions of the instrument (Wisc-r, Wisc-III, Wisc-IV) ((4), (5), (6) (7)) and also according to different criteria of selection (see (8) for persistent academic difficulties). The question about a dyslexic profile on the test is still open, perhaps due to different methodological choices in the different researches and to the use of different versions of Wechsler Scale for Children test. Purpose of this article is to describe performance on Wisc-IV test in Italian children, based on CHC model and to make a deeper analysis of cognitive profile, on single test level, and on indexes level. 168 children in the study were consecutively referred to the authors due to persistent academic difficulties and we selected 90 who have persistent difficulties related to reading (specific o unspecific) (from January 2013 to may 2014). Data on cognitive profile on single test level, and on indexes level are discussed, based on CHC model. Clinical issues are proposed, also aiming to the creation on personalized intervention, also in school
Estimativas de parâmetros genéticos e fenotípicos relacionados à tolerância ao alumínio em Brachiaria ruziziensis.
No full textForam avaliados 7 clones de B. ruziziensis, juntamente com trés testemunhas (cv. Marandu — B. brizantha; cv. Basilisk — B. decumbens; e cv. Comum — B. ruziziensis) quanto à tolerancia ao aluminio em solução nutritiva. Empregou-se o delineamento de blocos casualizados com trés repeti¢des e uma planta por parcela (vaso contendo 2 L de solução nutritiva). As mudas foram produzidas em tubetes plésticos, tiveram o sistema radicular lavado e foram colocadas em vasos plasticos contendo 2 L de solução nutritiva de Clark com 30 mg/L de aluminio. Foram mensurados os incrementos em crescimento da parte derea (IPA) e de raiz (IR), no volume de raizes (IVOL) e no nimero de perfilhos (NP), além das produgdes de massa verde e seca de parte aérea (MVPA e MSPA) e raizes (MVR e MSR). Os resultados das análises de variância detectaram diferenças significativas entre os genóipos para todas as caracteristicas avaliadas, evidenciando a existéncia de variabilidade genética dentro de B. ruziziensis para a tolerancia ao aluminio. O IVOL foi a caracteristica que apresentou maiores estimativas tanto para a relação dos coeficientes de variação ambiental e genética como para a herdabilidade
Avaliação de clones de Brachiaria ruziziensis quanto a tolerância a baixas temperaturas.
No full textSeleção de genótipos de Cynodon quanto à resistência à Mahanarva spectabilis (Hemiptera: Cercopidae).
No full textSeleção de genótipos de Cynodon nlemfuensis provenientes de coleta de sementes de grama estrela roxa.
No full textForam avaliados 195 genótipos provenientes de sementes coletadas em pastagens de Grama Estrela Roxa em blocos aumentados, com 5 testemunhas comuns em cada bloco. Foram realizados dois cortes de avaliação, com intervalos de crescimento de aproximadamente 30 dias, avaliando-se a produtividade de massa verde de forragem (PV). Os genótipos avaliados apresentaram variabilidade genética, com destaque para o clone 14
Seleção de genótipos de Cynodon nlemfuensis provenientes de coleta de sementes de Grama Estrela Roxa.
No full textForam avaliados 195 genótipos provenientes de sementes coletadas em pastagens de Grama Estrela Roxa em blocos aumentados, com 5 testemunhas comuns em cada bloco. Foram realizados dois cortes de avaliação, com intervalos de crescimento de aproximadamente 30 dias, avaliando-se a produtividade de massa verde de forragem (PV). Os genótipos avaliados apresentaram variabilidade genética, com destaque para o clone 14
CLINICAL EXPERIENCE WITH A SIROLIMUS-ELUTING NITINOL STENT IN A BIODEGRADABLE POLYMER MATRIX USING THE CARDIOMIND® 0.014″ SPARROW® STENT SYSTEM
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Accademia e politica attiva: le edizioni, le traduzioni e i commenti alla "Politica" di Aristotele in Italia nei secoli XV-XVI
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