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    Egr-1 and Hipk2 are required for the TrkA to p75(NTR) switch that occurs downstream of IGF1-R

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    The aging program mediated by IGF1-R is responsible for a naturally occurring TrkA to p75(NTR) switch that leads to activation of the second messenger ceramide and increased production of the Alzheimer's disease amyloid beta-peptide. Biochemical and genetic approaches that target IGF1-R signaling, p75(NTR), or ceramide are able to block the above events. Here, we show that the transcription factors Egr-1 and Hipk2 are required elements for the TrkA to p75(NTR) switch downstream of IGF1-R signaling. Specifically, Egr-1 is required for the upregulation of p75(NTR), whereas Hipk2 is required for the downregulation of TrkA. In fact, gene silencing of Egr-1 abolished the ability of IGF1 to upregulate p75(NTR), whereas similar approaches directed against Hipk2 blocked the downregulation of TrkA. In addition, IGF1 treatment favored binding of Egr-1 and Hipk2 to the promoter of p75(NTR) and TrkA, respectively. Finally, the expression levels of both Egr-1 and Hipk2 are upregulated in an age-dependent fashion. Such an event is opposed by caloric restriction, a model of delayed aging, and favored by the p44 transgene in p44(+/+) animals, a model of accelerated aging
    Catalogo dei prodotti della ricerca Università degli Studi di Verona

    A 2 h periodic variation in the low-mass X-ray binary Ser X-1

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    Spectroscopy of the low-mass X-ray binary Ser X-1 using the Gran Telescopio Canarias have revealed a ?2 h periodic variability that is present in the three strongest emission lines. We tentatively interpret this variability as due to orbital motion, making it the first indication of the orbital period of Ser X-1. Together with the fact that the emission lines are remarkably narrow, but still resolved, we show that a main-sequence K dwarf together with a canonical 1.4 M? neutron star gives a good description of the system. In this scenario, the most likely place for the emission lines to arise is the accretion disc, instead of a localized region in the binary (such as the irradiated surface or the stream-impact point), and their narrowness is due instead to the low inclination (?10°) of Ser X-1
    Southampton (e-Prints Soton)
    Crossref
    Warwick Research Archives Portal Repository

    Ligusticum gongshanense sp nov (Umbelliferae) from western Yunnan, China

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    Ligusticum gongshanense Pu, R. Li & H. Li, a new species of Umbelliferae from western Yunnan, China, is described and illustrated. It is closely similar to L. franchetii H. de Boissieu, but differs by having unbranched and light yellow stem, white petals, and styles shorter than stylopodium
    Institutional Repository of Chengdu Institute of Biology, CAS

    A N A LI SI S KE L I ST R I KA N Y A N G D I HA SI LKA N LIMBA H BU A H D A N SA Y U R A N SEB A GA I EN ER GI A LTER N A TI F BI O BA TER A I

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    L im ba h bua h bu a ha n d a n sa y u r sa y u ra n y a ng sudah membusuk ba n y a k ter li ha t di pa sa r sa y ur da n bua h. L im ba h bu a h da n s a y ur y a ng membusuk menga lami pr oses kim ia y a ng d iken a l se ba ga i fe rm e ntasi. S e lama pr oses ini , bua h b ua ha n da n sa y u ra n mengha sil ka n a sa m lebih y a ng a k a n meni ngka tkan ke kua tan e lektr oli t da lam bua h da n sa y ur a n. S e hin gga , jus da ri bua h da n sa y u r a n y a ng tua a tau bus uk menja di lebih re a kti f de nga n e lek troda da n mengha sil ka n tega nga n y a ng lebih ti nggi da ripa da jus bua h a tau sa y u r y a ng se ga r . D a ri sifa t k e li strikan y a ng menga ndu ng ba n y a k e lektro li t da ri li mbah b ua h bua ha n da n sa y u r s a y u ra n ter se but , p e ne li ti be rtujua n untuk menge tahui nil a i kua t a rus da n teg a n ga n y a ng dih a sil ka n oleh bio ba ter a i li mbah bua h jer uk, pisan g, tom a t, c a b a i da n wor t e l guna untuk membua t bio ba ter a i y a ng opti mal P e ne li ti a n dil a kuka n da lam e mpat taha p. Ta ha p pe rta ma untuk menge tahui pe nga ruh jar a k a ntar e le ktroda ter ha da p kua t a ru s da n tega nga n y a ng dihasil ka n oleh bio ba ter a i tunggal li mbah bua h da n sa y ur a n. J a ra k a ntar e lektro da y a ng digunaka n a da lah 2 c m, 4 c m, 6 c m, 8 c m da n 10 c m d e nga n mengguna ka n e l e ktroda C u se ba ga i a noda da n Zn se ba ga i ka toda. L u a s e lektro da y a ng digunaka n (6 x 4) c m y a ng dice lupkan pa da wa d a h bio ba ter a i de ng a n volum e e lektro li t 750 ml . Ta ha p ke dua untuk menge tahui nil a i kua t a rus d a n teg a nga n y a ng dih a sil ka n bio b a ter a i se ri pa ra r e l. Elektr oda y a ng digunaka n lempe nga n C u da n Zn masing masing 6 bua h de nga n 6 wa da h bio ba t e ra i y a ng a k a n disus un se c a r a se ri pa r a r e l da n d iukur kua t a rus da n tega nga n. Ta h a p ke ti ga a da lah untuk m e nge tahui bio ba ter a i li mbah bua h da n sa y u ra n mana y a ng da pa t men y a l a ka n lamp u led y a ng pa li ng lama . Da n taha p ter a khir a d a lah me nguku r hu bunga n kua t a rus da n tega nga n de ng a n pH. Meng a c u pa d a ha sil da n a na li sis se c a ra k e se luru ha n didapa tkan ha sil ba hwa pe ruba ha n va ria si jar a k, ha mbata n da n pH a ka n membe ri ka n nil a i kua t a rus da n tega nga n y a ng be rb e da . S e makin de ka t jar a k a nta r e lektro da , se makin be s a r nil a i a rus da n tega nga n, d a n se m a kin be sa r nil a i ha mba tan, kua t a rus se makin ke c il da n tega nga n s e makin b e sa r. B e git u juga se makin be s a r nil a i p H mak a se m a kin ke c il ku a t a rus da n teg a nga n y a ng d ihasil ka n da n seb a li kn y a . Nilai pH ter ke c il diha sil ka n oleh bio ba te ra i L im ba h bua h J e ruk de nga n n il a i pH 4,03. B io ba ter a i tunggal y a ng mengh a sil ka n nil a i kua t a rus d a n tega nga n y a n g be sa r pa d a se luruh bio ba ter a i tunggal dim il iki oleh bio ba ter a i d e nga n jar a k a nta r e lektro da ter d e ka t 2 c m. B io ba ter a i li mbah bua h da n sa y u ra n y a ng m e ngha sil ka n nil a i kua t a rus da n tega nga n ter be sa r ba ik bio ba ter a i tunggal maupun bio ba ter a i se ri pa r a re l dim il iki oleh bio ba ter a i li mbah bua h jer uk de ng a n nil a i kua t a rus pa d a bio ba ter a i s e ri pa ra r e l 0,93 mA da n nil a i teg a nga n 2,72 volt . B io ba ter a i y a ng mampu men y a lak a n la mpu L ED ter lama a d a l a h bio ba ter a i li mbah bua h J e ruk de nga n lama w a ktu 75 j a m. da n sa y u ra n mana y a ng da pa t men y a l a ka n lamp u led y a ng pa li ng lama . Da n taha p ter a khir a d a lah me nguku r hu bunga n kua t a rus da n tega nga n de ng a n pH. Meng a c u pa d a ha sil da n a na li sis se c a ra k e se luru ha n didapa tkan ha sil ba hwa pe ruba ha n va ria si jar a k, ha mbata n da n pH a ka n membe ri ka n nil a i kua t a rus da n tega nga n y a ng be rb e da . S e makin de ka t jar a k a nta r e lektro da , se makin be s a r nil a i a rus da n tega nga n, d a n se m a kin be sa r nil a i ha mba tan, kua t a rus se makin ke c il da n tega nga n s e makin b e sa r. B e git u juga se makin be s a r nil a i p H mak a se m a kin ke c il ku a t a rus da n teg a nga n y a ng d ihasil ka n da n seb a li kn y a . Nilai pH ter ke c il diha sil ka n oleh bio ba te ra i L im ba h bua h J e ruk de nga n n il a i pH 4,03. B io ba ter a i tunggal y a ng mengh a sil ka n nil a i kua t a rus d a n tega nga n y a n g be sa r pa d a se luruh bio ba ter a i tunggal dim il iki oleh bio ba ter a i d e nga n jar a k a nta r e lektro da ter d e ka t 2 c m. B io ba ter a i li mbah bua h da n sa y u ra n y a ng m e ngha sil ka n nil a i kua t a rus da n tega nga n ter be sa r ba ik bio ba ter a i tunggal maupun bio ba ter a i se ri pa r a re l dim il iki oleh bio ba ter a i li mbah bua h jer uk de ng a n nil a i kua t a rus pa d a bio ba ter a i s e ri pa ra r e l 0,93 mA da n nil a i teg a nga n 2,72 volt . B io ba ter a i y a ng mampu men y a lak a n la mpu L ED ter lama a d a l a h bio ba ter a i li mbah bua h J e ruk de nga n lama w a ktu 75 j a m
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    Populationsgenetische Differenzierung beim Eichenwickler (Tortrix viridana L.) und seiner Wirtspflanze (Quercus robur L.) anhand nukleärer Genmarker

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    In Western Europe pedunculate oak (Quercus robur L.) is the forest tree with the highest number of phytophagous insect species (Yela & Lawton 1997). One of these, the green oak leaf roller Tortrix viridana L. is an oligophagous herbivorous moth with a host range limited to the genus Quercus (Hunter 1990, Du Merle 1999). During outbreaks, T. viridana often leads to defoliation of oaks in spring. The abundance of T. viridana is subject to the population size fluctuations typical for herbivorous insects, where periods of small population sizes (latent periods) alternate with periods of high population sizes (outbreak) (e.g. Schütte 1957, Horstmann 1984). Apart from many experimental studies on population dynamics of the moth (e.g. Hunter 1990, Du Merle 1999, Ivashov & al. 2002) so far little attention has been paid to the genetic variation within the species as an important aspect of the genetics of this host-parasite interaction. Simchuk & al. (1999) found changes in the heterozygosity level of different isozyme loci during outbreaks in T. viridana and molecular markers for T. viridana have been developed for analyses of genetic variation within and among populations (Schroeder & Scholz 2005). But, investigations of genetic variation within and among populations of forest pest species are important to predict future pest outbreaks. So far the processes outbreaks based on are not entirely clarified, however it is known that migration plays a major role. Using molecular markers investigations of the genetic variation are possible and offer the opportunity to analyse distribution events. In this paper first results are presented concerning the genetic variation of the green oak leaf roller at three geographic scales: (1) among trees within a population, (2) among populations at a small spatial scale of about 150 km and (3) among populations at a broader geographic scale up to 3000 km. Furthermore results of the genetic variation of oaks at the small spatial scale are represented.Populationen des grünen Eichenwicklers (Tortrix viridana L., Lepidoptera: Tortricidae) und der Stieleiche (Quercus robur L., Fagaceae) wurden auf genetische Differenzierungen mit Hilfe von Kern-DNA-Markern untersucht. Insgesamt wurden 14 Eichenbestände in Nordrhein-Westfalen (NRW) und 7 weitere in verschiedenen Regionen Europas in die Untersuchung einbezogen. Weder für die Eiche noch für den Eichenwickler sind genetische Differenzierungen der Populationen auf einer kleinen geographischen Skala (etwa 150 km) nachweisbar, jedoch zeigen die Eichenpopulationen eine zunehmende genetische Distanz mit zunehmender geographischer Distanz. Für den Eichenwickler konnten innerhalb von Populationen in einem Radius von etwa 40 m Familienstrukturen ermittelt werden und auf einer kontinentalen Skala lassen sich die Ergebnisse für den Eichenwickler mit einer „isolation by distance“ erklären
    Hochschulschriftenserver - Universität Frankfurt am Main

    E RB E DA AN P E RI L AKU S E KS UA L RE M AJA YA NG M E NGI KUT I DA N T I DA K M E NGI KUT I P USAT I NF ORM ASI DA N KO S E L I NG RE M AJA ( P I K R ) P AD A RE M AJA S M U DI KAB UP AT E N JE M B E R

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    M a s a r e m a j a m e r upa ka n m a s a pe r a li ha n da r i m a s a a n a k a n a k m e n u j u m a s a de wa s a de n ga n u s i a a n t a r a 10 24 t a h un . P e r t um b u h a n da n pe r ke m ba n g a n y a n g d i a l a mi r e m a j a d i pe n ga r u hi o l e h f a kt or bi o l o g i s , e m o s i o na l , ko gni t i f , da n s o s i a l . R e m a j a m e m pu ny a i m a s a l a h y a n g s a n ga t ko m p l e ks s e i r i ng de n ga n m a s a t r a n s i s i y a n g d i a l a m i r e m a j a . P e r uba h a n pe r ub a ha n y a n g t e r j a d i pa da r e m a j a m e n e m pa t ka n r e m a j a s e b a ga i ke l o m po k b e r e s i ko d i ke hi dup a nny a . F a kt o r y a n g m e m pe n ga r u hi p e r i l a ku s e ks ua l r e m a j a a da l a h m e ni ngka t ny a do r o n ga n s e ks u a l , pe n u n da a n us i a pe r ka w i na n , t a b u a t a u l a r a nga n , kur a n g ny a p e n ge t a h ua n ke s e h a t a n r e pr o duks i da n pe r ga u l a n s e m a k i n b e ba s ( S a r w o n o, 2011) . B e r da s a r ka n h a s il s ur v e i pe r i l a ku s e ks ua l y a n g be r e s i ko pa da r e m a j a o l e h K o m n a s P e r l i ndu n ga n An a k I n do ne s i a ( K P A I ) t a h un 2009 d i 33 pr o vi ns i m e ny e b ut ka n b a h wa 22, 6% r e m a j a pe r n a h m e l a k uka n h u b u n ga n s e ks da n 62, 7% r e m a j a S M A t i da k pe r a wa n . Ha s i l pe ne l i t i a n y a ng d i l a kuka n o l e h P r a s t i w i t a h u n 2009 t e r h a da p pe r i l a ku s e k s ua l r e m a j a d i J e m be r di da pa t ka n b a h wa , s e b a ny a k 76% a da l a h pe r i l a ku s e k s ua l pa s i f ( b e r c i u m a n , m e r a ba , pe tt i n g) , s e da n gka n pe r i l a ku s e ks u a l a kt i f ( int e r c ou r s e ) s e b a ny a k 24% . P e r m a s a l a ha n ke s e ha t a n r e pr o duks i k h u s us ny a pe r i l a ku s e k s ua l b e r e s i ko r e m a j a de n ga n pr o gr a m pr o m o s i ke s e h a t a n da pa t di l a kuka n m e l a l u i pe m be r i a n i n f o r m a s i t e n t a n g a s pe k bi o l o g i s da r i s e k s , nil a i b uda y a da n s o s i a l , s e r t a pe du li pa da s i ka p da n pe r a s a a n ( All e n d e r & S pa r d l e y , 2001) . P us a t I nf o r m a s i da n K o ns e li ng R e m a j a ( P I K R) a da l a h s u a t u wa da h ke g i a t a n pr o gr a m ke s e ha t a n r e pr o duks i r e m a j a ( K R R ) y a n g d i k e l o l a da r i , o l e h , da n u n t uk r e m a j a gu na m e m be r i ka n pe l a y a na n i n f o r m a s i da n ko n s e li ng t e n t a n g ke s e h a t a n r e pr o du ks i r e m a j a . T uj u a n pe ne l i t i a n i n i a da l a h m e n ga n a li s i s p e r b e da a n pe r i l a ku s e k s u a l r e m a j a y a n g m e n g i kut i da n t i da k m e ng i kut i pu s a t i n f o r m a s i da n ko ns e li ng r e m a ja ( P I K R ) pa da r e m a j a S M U d i Ka b upa t e n J e mb e r . De s a i n pe n e li t i a n a da l a h kua n t i t a t i f m e n ggu na ka n m e t o de o b s e r v a s i o na l a na l i t i k de n ga n pe n de ka t a n c r os s s e c ti onal . P o pul a s i pa da pe ne l i t i a n i n i s e b a ny a k 5 07 s i s wa S M U Ne g e r i “ X” d a n 742 s i s wa S M K Ne ge r i “ Y” J e m be r . S a m p e l y a n g d i a m b il da l a m pe n e li t i a n s e b a ny a k 168 o r a n g, y a n g t e r b a g i da l a m 2 ke l o m po k, y a i t u 84 r e s po n de n y a ng m e n g i kut i da n 84 r e s p o n de n y a ng t i da k m e n g i kt i P I K R. T e k ni k pe mi li ha n s a m pe l y a n g d i gu na ka n a d a l a h multi s tage r ando m s ampling . U ji v a li d i t a s da n r e l i a bil i t a s m e n g gu n a ka n P e ar s on P r oduc t M o me nt da n u ji A lpha C r onbac h . An a li s a da t a m e n ggu n a ka n c hi s quar e . Ha s il pe n e li t i a n m e n u nj ukka n ba h wa s e b a g i a n b e s a r r e m a j a y a n g m e n g i kut i PI K R t e r g o l o n g m e mi li k i pe r i l a ku s e ks ua l t i d a k be r e s i ko y a i t u s e b e s a r ( 69% ) da n s e b e s a r ( 31% ) t e r g o l o n g pe r i l a ku s e ks ua l r e ma j a b e r e s i ko . S e da n gka n pa d a r e m a j a y a n g t i da k m e n g i kut i P I K R s e b a g i a n b e s a r t e r g o l o n g m e mi li k i pe r i l a ku s e ks ua l r e m a j a be r e s i ko s e b e s a r ( 52, 4% ) da n s e be s a r ( 47, 6% ) t e r g o l o n g pe r i l a ku s e ks ua l r e m a j a t i da k b e r e s i ko . P e r hi t un g a n u ji s t a t i s t i k c hi s quar e d i da pa t ka n p v alue 0, 008 da n OR 0, 408 y a n g b e r a r t i Ho di t o l a k. K e s im pu l a n da r i pe n e li t i a n i n i a da l a h a da pe r b e da a n pe r i l a ku s e k s ua l r e m a j a pa da r e m a j a y a ng m e n g i k ut i da n t i da k P I K R p a da r e m a ja S M U d i Ka b upa t e n J e m be r . T e r da pa t a s o s i a s i po s i t i f de n ga n k e c e n de r u n ga n r e m a j a y a n g m e n g i kut i P I K R m e mi li k i pe r i l a k u s e ks ua l t i da k be r e s i ko l e b ih b e s a r d i b a n d i ngka n de n ga n r e m a j a y a n g t i da k m e n g i kut i . S a r a n pe n e li t i a n a da l a h pe r l u a da ny a t i n da k l a nj ut da r i t e n a ga ke s e h a t a n s e t e m pa t t e r u t a m a p e r a wa t ko m u ni t a s m e l a l u i pus a t i nf o r m a s i d a n ko n s e li ng r e m a j a ( P I K R) de n ga n t i n da ka n pe n c e ga h a n be r upa pr e v e n s i pr i m e r , s e ku n de r , da n t e r s i e r de n g a n pe n de k a t a n ko n s e p at r is k t e r ka i t pe r m a s a l a h a n pe r i l a ku s e k s u a l b e r e s i ko pa da r e m a j a
    UNEJ Repository

    A J I A N F I S I O L O G I S P E M B E R I A N N I T R O G E N Y A N G B E R B E D A T E R H A D A P P E R T U M B U H A N T A N A M A N S U W E G ( A m o r p h o p h a l l u s c a m p a n u l a t u s )

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    S uwe g ( A mor phophall us c ampanulatus ) a da l a h u m bi pa li ng b e s a r d i duni a . K e l e bi ha n u m b i s uw e g a da l a h ka n du n g a n s e r a t pa n ga n , pr ot e i n da n ka r b o hi dr a t ny a y a n g c ukup t i n gg i de n ga n ka da r l e m a k y a n g r e n da h . D i I n do n e s ia kur a n g m e m a nf a a t ka n s uwe g s e b a g a i a l t e r n a t i f l a i n b a h a n pa n ga n s u m be r ka r b o hi dr a t . P e l ua n g pa s a r s u we g s a n ga t b e s a r , b a i k u n t uk pa s a r da l a m n e ge r i m a upu n pa s a r l ua r n e ge r i . S e l a m a i n i pa s o ka n h a ny a d i p e n u hi da r i pe da ga ng ke c i l y a n g m e n gu m pu l ka n u m bi y a n g t u m b u h l i a r d i hut a n a t a u d i s e k i t a r pe r ke b u n a n da n l a m a ke l a m a a n a ka n h a bi s ji ka t i d a k d i upa y a ka n pe n a n a m a nny a . P e n e li t i a n i n i b e r t uj ua n u n t uk m e n ge t a h u i l a j u p e r t um b u h a n , ka n du n g a n k l o r o f i l , pr o t e i n da n ka r b o hi dr a t pa da t a n a m a n s uwe g ( A mor phophall u s c ampanulatus ) pa da pe m be r i a n ni t r o ge n y a n g b e r b e da . M e t o de pe n e li t i a n y a ng d i gu n a ka n a da l a h R a n c a n ga n Ac a k L e n gka p de nga n f a kt o r pe m upuka n N y a ng t e r di r i a t a s t uj u h t a r a f . y a i t u 0 , 0. 5 , 1. 0 , 1 . 5, 2 . 0, 2. 5 da n 3. 0 g ur e a / t a n a m a n de n ga n m a s i ng m a s i ng 3 ka l i u l a n ga n . Ha s il p e n e li t i a n m e n u nj ukka n b a h wa u n t uk t a n a m a n s uwe g, pe m be r i a n N pa da m a s i ng m a s i ng p e r l a ku a n m e m be r i ka n p e n ga r u h be r b e d a t i da k ny a t a t e r h a da p s e l ur u h pa r a m e t e r pe n ga m a t a n . l a j u pe r t um b u h a n t i n gg i da n d i a m e t e r t a n a m a n s uwe g t e r t i n gg i t e r da pa t pa da pe r l a kua n N 0. 5 g/t a n a m a n y a i t u 3. 48 c m da n 0. 5 c m pe r mi nggu. K a n du n g a n k l o r o f il da n pr ot e i n t e r t i n gg i t e r da pa t pa da pe r l a kua n N 1. 5 g/t a n a m a n , y a i t u 0. 46% da n 1. 25% . S e da n gka n ka n du n ga n ka r b o hi dr a t t e r t i n gg i t e r da pa t pa da t a n a m a n s u w e g de n ga n p e r l a ku a n 1 g/t a n a m a n y a i t u 0. 318%
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    Measurements of K S 0 KS0 {K}_S^0 - K L 0 KL0 {K}_L^0 asymmetries in the decays Λ c + → p K L , S 0 Λc+→pKL,S0 {\Lambda}_c^{+}\to p{K}_{L,S}^0 , p K L , S 0 π + π − pKL,S0π+π− p{K}_{L,S}^0{\pi}^{+}{\pi}^{-} and p K L , S 0 π 0 pKL,S0π0 p{K}_{L,S}^0{\pi}^0

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    Abstract Using e + e − annihilation data sets corresponding to an integrated luminosity of 4.5 fb −1, collected with the BESIII detector at center-of-mass energies between 4.600 and 4.699 GeV, we report the first measurements of the absolute branching fractions B Λ c + → p K L 0 B(Λc+→pKL0) \mathcal{B}\left({\Lambda}_c^{+}\to p{K}_L^0\right) = (1.67 ± 0.06 ± 0.04)%, B Λ c + → p K L 0 π + π − B(Λc+→pKL0π+π−) \mathcal{B}\left({\Lambda}_c^{+}\to p{K}_L^0{\pi}^{+}{\pi}^{-}\right) = (1.69 ± 0.10 ± 0.05)%, and B Λ c + → p K L 0 π 0 B(Λc+→pKL0π0) \mathcal{B}\left({\Lambda}_c^{+}\to p{K}_L^0{\pi}^0\right) = (2.02 ± 0.13 ± 0.05)%, where the first uncertainties are statistical and the second systematic. Combining with the known branching fractions of Λ c + → p K S 0 Λc+→pKS0 {\Lambda}_c^{+}\to p{K}_S^0 , Λ c + → p K S 0 π + π − Λc+→pKS0π+π− {\Lambda}_c^{+}\to p{K}_S^0{\pi}^{+}{\pi}^{-} , and Λ c + → p K S 0 π 0 Λc+→pKS0π0 {\Lambda}_c^{+}\to p{K}_S^0{\pi}^0 , we present the first measurements of the K S 0 KS0 {K}_S^0 - K L 0 KL0 {K}_L^0 asymmetries R Λ c + K S , L 0 X = B Λ c + → K S 0 X − B Λ c + → K L 0 X B Λ c + → K S 0 X + B Λ c + → K L 0 X R(Λc+,KS,L0X)=B(Λc+→KS0X)−B(Λc+→KL0X)B(Λc+→KS0X)+B(Λc+→KL0X) R\left({\Lambda}_c^{+},{K}_{S,L}^0X\right)=\frac{\mathcal{B}\left({\Lambda}_c^{+}\to {K}_S^0X\right)-\mathcal{B}\left({\Lambda}_c^{+}\to {K}_L^0X\right)}{\mathcal{B}\left({\Lambda}_c^{+}\to {K}_S^0X\right)+\mathcal{B}\left({\Lambda}_c^{+}\to {K}_L^0X\right)} in charmed baryon decays: R Λ c + p K S , L 0 = − 0.025 ± 0.031 R(Λc+,pKS,L0)=−0.025±0.031 R\left({\Lambda}_c^{+},p{K}_{S,L}^0\right)=-0.025\pm 0.031 , R Λ c + p K S , L 0 π + π − = − 0.027 ± 0.048 R(Λc+,pKS,L0π+π−)=−0.027±0.048 R\left({\Lambda}_c^{+},p{K}_{S,L}^0{\pi}^{+}{\pi}^{-}\right)=-0.027\pm 0.048 and R Λ c + p K S , L 0 π 0 = − 0.015 ± 0.046 R(Λc+,pKS,L0π0)=−0.015±0.046 R\left({\Lambda}_c^{+},p{K}_{S,L}^0{\pi}^0\right)=-0.015\pm 0.046 . No significant asymmetries with statistical significance are observed
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    P E NGAR UH R E M E DI A L M A S S A GE KAKI T E RHAD AP GANGGUAN S I RKUL ASI DA RA H P E RI F E R P AD A KL I E N DI AB E T E S M E L L I T US T I P E 2 DI WI L AY AH KE RJA P USK E S M AS P AT RA NG KAB UP AT E N JE M B E R

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    D i a b e t e s M e ll i t us t i pe 2 m e r upa ka n ga n ggua n s e k r e s i i ns u li n pr o gr e s i f y a ng da pa t b e r a k i ba t t i m bu l n y a r e s i s t e ns i t e r h a da p i ns u li n . P e r ub a ha n pa t o l o g i s u m u m n y a d i a l a mi k li e n D M t i pe 2 a da l a h pe r u b a h a n y a n g m e li ba t ka n s i s t e m pe m b u l u h da r a h d i be r b a g a i b a g i a n t ub u h . Ga n ggua n s i r ku l a s i t e r j a d i pa d a pe r e da r a n da r a h pe r i f e r t e r ut a m a d i ka k i d a n t un g ka i b a wa h . Ga n ggu a n s i r ku l a s i da r a h pe r if e r da pa t m e ny e ba b ka n k li e n D M t i pe 2 be r e s i ko m e n ga l a mi t r a u m a pa da ka k i . Ha s il s t ud i pe n d a h u l u a n y a n g t e l a h d i l a kuka n , s e ba ny a k 53 k li e n D M t i pe 2 d i w il a y a h ke r j a P us ke s m a s P a t r a n g be l u m m e n ge t a h u i s e c a r a j e l a s c a r a me l a kuka n pe r a wa t a n ka k i u n t uk m e n g a t a s i ke l u ha n da r i ge j a l a y a n g d i t im bu l k a n da r i ga n ggua n s i r ku l a s i da r a h p e r i f e r . S e b a ny a k 8 da r i 10 k l i e n DM t i pe 2 d i w i l a y a h k e r j a P us ke s m a s P a t r a n g m e n ga l a mi ke l u h a n t e r h a d a p ge j a l a da r i ga n ggua n s i r ku l a s i da r a h pe r i f e r s e pe r t i ny e r i s a a t b e r j a l a n , m a t i r a s a , ka k i m e n ga l a mi kr a m , ke s e m ut a n , ka k i m e n ga l a mi ny e r i s e pe r t i t e r b a ka r , da n hil a n g ny a n a d i pe d i s . Upa y a u n t uk m e n ga t a s i ga n ggua n s i r ku l a s i da r a h pa da ka k i y a ng d i a l a m i o l e h k li e n DM t i pe 2 d i w i l a y a h ke r j a P u s ke s m a s P a t r a n g a ga r da pa t di l a kuka n de n ga n c e pa t da n t e pa t , s e hi ngga pe m u li ha n ge ja l a da n pe nc e ga h a n ko m p li ka s i pe ny a k i t d a pa t s e ge r a d i a t a s i . S a l a h s a t u t i n d a ka n r e h a bi li t a t i f y a n g da pa t d i l a kuka n u n t uk m e n a n ga ni ga n gg u a n s i r ku l a s i d a r a h pe r i f e r pa d a ka k i d i a b e t e s a da l a h t i n d a ka n ma s s age d e n ga n t e kni k r e me di al mas s age . R e me dial ma s s ag e a da l a h s ua t u p i j a t a n y a ng d il a kuka n u n t uk m e m b a n t u m e m pe r c e p a t pr o s e s pe m u li ha n b e be r a pa m a c a m pe ny a k i t de n ga n m e n ggu n a ka n s e n t uh a n t a n g a n da n t a n pa m e m a s ukka n o b a t ke da l a m t ub u h . T u j ua n p e n e li t i a n i n i u n t uk m e n ga n a li s is http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ pe n ga r u h r e me dial mas s age ka k i t e r ha da p ga n gg ua n s i r ku l a s i d a r a h pe r i f e r pa d a k l i e n d i a b e t e s m e ll i t us t i pe 2 d i W il a y a h Ke r j a P us ke s m a s P a t r a n g Ka b upa t e n J e m be r . Ha s i l p e n e li t i a n i ni d i ha r a pk a n da pa t m e m be r i pe n ge t a h ua n b a r u t e n t a ng pe n a n g a n a n ga n ggu a n s i r ku l a s i da r a h pe r i f e r pa d a k l i e n DM s e hi ngga r e m e dial mas s age ka k i m a m pu d i a p li ka s i k a n da l a m p e m b e r i a n pe l a y a n a n k e s e h a t a n p a da k l i e n DM . P e n e li t i a n i ni m e n ggu n a ka n de s a i n pe ne l i t i a n qu as i e k s pe r im e ntal de n ga n r a n c a n ga n pr e tes t da n po s t tes t w it h c ont r ol gr o up de s ign . P e n ga m b il a n s a m p e l m e n ggu n a ka n t e kni k pr obabil it y s a mpling y a i t u s i mple r andom s ampling . S a m p e l da l a m pe n e li t i a n i n i s e j u ml a h 2 0 o r a n g y a n g t e r ba g i da l a m 2 ke l o m po k, y a i t u 1 0 o r a n g m e nj a d i ke l o m po k ko n t r o l da n 1 0 o r a n g l a i nn y a m e nj a d i ke l o m po k pe r l a kua n . Da t a di a n a li s i s m e n ggu n a ka n I nde pe nde nt T tes t un t uk m e n ge t a h u i pe n ga r u h r e me dial mas s age ka k i t e r h a da p ga n ggu a n s i r ku l a s i da r a h pe r i f e r . Ha s il pe n go l a h a n da t a de n g a n S P S S d i da pa t ka n I nde pe nde nt T tes t ga n ggua n s i r ku l a s i da r a h pe r i f e r pa da ke l o m po k pe r l a kua n d a n ke l o m po k ko n t r o l de n ga n ha s il I nde pe nde nt T tes t pa d a ge j a l a s u bj e kt i f ga n ggua n s i r ku l a s i da r a h pe r i f e r d i da pa t ka n nil a i t 6, 601 ( p = 0 , 000) pa da ka k i ka n a n d a n nil a i t 7, 942 ( p = 0, 000) pa da ka k i k i r i , s e da n gka n pa da ge j a l a o bj e kt i f ga n ggua n s i r ku l a s i da r a h pe r i f e r d i d a pa t ka n nil a i t 9, 733 ( p = 0, 000) pa da ka k i k a n a n da n ni l a i t 7, 800 ( p= 0, 000) pa da ka k i k i r i . N il a i p v alue < α ( α = 0. 05) y a n g b e r a r t i H d i t o l a k, s e hi ngga da pa t di t a r i k ke s i m pu l a n b a h wa a da pe n ga r u h r e me dial mas s age ka k i t e r h a da p ga n ggua n s i r ku l a s i da r a h pe r i f e r pa da k li e n D M t i p e 2 d i W il a y a h Ke r j a P us ke s m a s P a t r a n g K a b upa t e n J e m be r . S a r a n da r i pe n e li t i a n i ni a da l a h pe r a wa t http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ x http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ http://digilib.unej.ac.id/ 0 da pa t m e m be r i ka n r e me dial ma s s age ka k i u nt uk m e n ga t a s i ke l u h a n ge j a la ga n ggua n s i r ku l a s i d a r a h pe r i f e r p a da k li e n D M t i pe 2 da n da pa t m e nj a d i ka n r e me dial mas s ag e ka k i s e b a ga i s ua t u pr o gr a m pr o m o s i ke s e ha t a n da n upa ya pr e v e n t i f u n t uk m e ni ngka t ka n ke m a m pua n pe r a wa t a n ka k i k l i e n DM t i p e 2
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    Luminescence quenching measurements on zeolite L monolayers

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    The luminescence quenching of the oxygen sensitive Ru2+ complex (Ru-ph4-TMS) used as a stopcock and attached to a zeolite L monolayer has been investigated. The luminescence lifetime of the attached Ru-ph4-TMS was the same under N2 and under O2 atmosphere. This remarkable result is attributed to the shielding provided by the channels of the zeolite L crystals arranged as a monolayer. The emitting 3MLCT state of the Ru-ph4-TMS stopcock is localized on the ligand bearing the phenyl groups forming the tail of this complex, which deeply penetrates into the zeolite L channel
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