1,565 research outputs found
Challenges in Monte Carlo event generator software for high-luminosity LHC
No full textThis work received funding from the European
Union’s Horizon 2020 research and innovation programme as part of the Marie Skłodowska-Curie Innovative Training Network MCnetITN3
(grant agreement no. 722104).Valassi, A., Yazgan, E., McFayden, J., Amoroso, S., Bendavid, J., Buckley, A., Cacciari, M., Childers, T., Ciulli, V., Frederix, R., Frixione, S., Giuli, F., Grohsjean, A., Gütschow, C., Höche, S., Hopkins, W., Ilten, P., Konstantinov, D., Krauss, F., Li, Q., Lönnblad, L., Maltoni, F., Mangano, M., Marshall, Z., Mattelaer, O., Fernandez Menendez, J., Mrenna, S., Muralidharan, S., Neumann, T., Plätzer, S., Prestel, S., Roiser, S., Schönherr, M., Schulz, H., Schulz, M., Sexton-Kennedy, E., Siegert, F., Siódmok, A., Stewart, G.A., The HSF Physics Event Generator W
Increased lipid peroxidation in adult GH-deficient patients: effects of short-term GH administration
No full textAbstract: Objective: Adult GH deficiency (GHD) syndrome is characterized by increased risk of atherosclerosis and hence of cardio- and cerebrovascular mortality. Oxidative stress appears to play an important role in early atherogenesis. Oxidized LDL represents an important predictor of cardiovascular risk and is mainly responsible for oxidative damage of the endothelium. Its concentrations are increased in GHD, but the association between this abnormality and oxidative stress is still unclear, due to the discordant results yielded by the few available studies. Design and methods: In 13 GHD patients, plasma lipid peroxide concentrations were measured before and after a 4-month treatment with recombinant human GH (rhGH) and compared with those of 13 age- and sex-matched controls. In the same subjects, the so-called "lag-time", an index of anti-oxidant activity and thus of plasma oxidative balance, was also measured using a fluorescence kinetics method. Results: Before treatment, peroxide levels were significantly higher in patients than in controls (374.0 +/- 31.52 vs 268.0 +/- 8.51 U.C., p < 0.01), whereas the lag-time was significantly lower (113.0 +/- 10.70 vs 168.0 +/- 7.80 min, p < 0.01). RhGH administration to patients resulted both in a significant decrease in lipid peroxide levels (from 374.0 +/- 31.52 to 336.0 +/- 33.17 U.C., p < 0.01) and a significant prolongation of lag-time (from 113.0 +/- 10.70 to 144.0 +/- 15.00 min, p < 0.01). After treatment, both parameters were no longer significantly different in patients and controls. Lag-time and peroxide levels at baseline did not show any correlation with IGF-I concentrations in GHD patients. After replacement therapy, however, lag-time was positively (r(2) = 0.62, p < 0.01), and peroxide levels negatively (r(2)=0.41, p < 0.05), correlated with IGF-I levels. Conclusions: These data support the view that adult GHD syndrome is characterized by an unbalance between pro- and anti-oxidant factors with marked preponderance of the former. This abnormality, likely contributing to the increased atherogenic risk of GHD patients, is corrected by short-term GH administration at a dose able to increase, although not to fully normalize, IGF-I levels
The effect of sildenafil on sleep related erections in hypogonadal men with and without testosterone replacement therapy. Preliminary data of randomized controlled study
No full textPreliminary data of a randomized placebo-controlled, crossover study evaluating a synergic effect of sildenafil and testosterone on sleep-related erections in hypogonadal me
Human models of estrogen deficiency
No full textDescription of human models of estrogen deficiency plays a key role in understanding the effect of estogens in me
Estrogens and male sexual behavior: insights from the natural model of congenital estrogen deficiency
No full textSexual behavior was investigated by a sexological interview in a man with aromatase deficiency and hypogonadism, suggesting that in men estrogens could play a role in sexual activity, but are not responsible for the development of a male gender identity and male sexual orientation
BEFORE BIRTH: UNDERSTANDING PRENATAL SCREENING
No full textList of contributors -- Ch. 1. A European project on the development of prenatal screening / Elizabeth Ettorre -- Ch. 2. Prenatal diagnosis in the lay press and professional journals in Finland, Greece and The Netherlands / Michaela Lauren, Konstantinos Petrogiannis, Eleni Valassi-Adam and Tjeerd Tymstra -- Ch. 3. Review of policy, law and ethics / Konstantinos Petrogiannis, Tjeerd Tymstra, Piia Jallinoja and Elizabeth Ettorre -- Ch. 4. Experts' views on prenatal screening and diagnosis in Greece, The Netherlands, England and Finland / Elizabeth Ettorre -- Ch. 5. Physicians' opinions of genetic screening: comparisons in Finland and Greece / Eleni Valassi-Adam, Elina Hemminki, Hanna Toiviainen and Christos Maragos -- Ch. 6. Prenatal diagnosis and screening in Europe: attitudes, practices and opinions of midwives / Loes Kooij, Rachel Grellier, Fani Pechlivani and Hanna Toiviainen -- Ch. 7. Women's decision-making and experiences of prenatal Down's syndrome screening / Paivi Santalahti, Konstantinos Petrogiannis and Tjeerd Tymstra -- Ch. 8. Whose fault is it? Shame and guilt for the genetic defect / Thalia Dragonas -- Ch. 9. Prenatal genetic screening: the Finnish experience / Arja R. Aro and Piia Jallinoja -- Ch. 10. Living with a congenital condition: the views of adults who have cystic fibrosis, sickle cell anaemia, Down's syndrome, spina bifida or thalassaemia / Priscilla Alderson, Penny Scott and Neelam Thapar -- Ch. 11. It's like peeking into a Christmas gift and then deciding if you want it or not' / Michaela Lauren -- Ch. 12. Eugenics: what is in a word? / Eleni Valassi-Ada
Effects of Sildenafil on Sleep-Related Erection in Healthy Men
No full textThis randomized, placebo-controlled, crossover study demostrate that sildenafil is effective in improving and ameliorate sleep-related erection, that are just normal, in healthy me
Search for supersymmetry with a dominant R-parity violating LLĒ coupling in e+e- collisions at centre-of-mass energies of 130 GeV to 172 GeV
No full textcomplete author list: Barate R.; Buskulic D.; Decamp D.; Ghez P.; Goy C.; Lees J.; Lucotte A.; Minard M.; Nief J.; Pietrzyk B.; Boix G.; Casado M.; Chmeissani M.; Crespo J.; Delfino M.; Fernandez E.; Fernandez-Bosman M.; Garrido L.; Grauges E.; Juste A.; Martinez M.; Merino G.; Miquel R.; Mir L.; Morawitz P.; Park I.; Pascual A.; Perlas J.; Riu I.; Sanchez F.; Colaleo A.; Creanza D.; de Palma M.; Gelao G.; Iaselli G.; Maggi G.; Maggi M.; Marinelli N.; Nuzzo S.; Ranieri A.; Raso G.; Ruggieri F.; Selvaggi G.; Silvestris L.; Tempesta P.; Tricomi A.; Zito G.; Huang X.; Lin J.; Ouyang Q.; Wang T.; Xie Y.; Xu R.; Xue S.; Zhang J.; Zhang L.; Zhao W.; Abbaneo D.; Alemany R.; Becker U.; Bright-Thomas P.; Casper D.; Cattaneo M.; Cerutti F.; Ciulli V.; Dissertori G.; Drevermann H.; Forty R.; Frank M.; Gianotti F.; Hagelberg R.; Hansen J.; Harvey J.; Janot P.; Jost B.; Lehraus I.; Mato P.; Minten A.; Moneta L.; Pacheco A.; Pusztaszeri J.; Ranjard F.; Rolandi L.; Rousseau D.; Schlatter D.; Schmitt M.; Schneider O.; Tejessy W.; Teubert F.; Tomalin I.; Vreeswijk M.; Wachsmuth H.; Wagner A.; Ajaltouni Z.; Badaud F.; Chazelle G.; Deschamps O.; Falvard A.; Ferdi C.; Gay P.; Guicheney C.; Henrard P.; Jousset J.; Michel B.; Monteil S.; Montret J.; Pallin D.; Perret P.; Podlyski F.; Proriol J.; Rosnet P.; Fearnley T.; Hansen J.; Hansen J.; Hansen P.; Nilsson B.; Rensch B.; Wäänänen A.; Daskalakis G.; Kyriakis A.; Markou C.; Simopoulou E.; Vayaki A.; Blondel A.; Brient J.; Machefert F.; Rouge A.; Rumpf M.; Valassi A.; Videau H.; Boccali T.; Focardi E.; Parrini G.; Zachariadou K.; Cavanaugh R.; Corden M.; Georgiopoulos C.; Huehn T.; Jaffe D.; Antonelli A.; Bencivenni G.; Bologna G.; Bossi F.; Campana P.; Capon G.; Chiarella V.; Felici G.; Laurelli P.; Mannocchi G.; Murtas F.; Murtas G.; Passalacqua L.; Pepe-Altarelli M.; Curtis L.; Dorris S.; Halley A.; Lynch J.; Negus P.; O'Shea V.; Raine C.; Scarr J.; Smith K.; Teixeira-Dias P.; Thompson A.; Thomson E.; Thomson F.; Ward J.; Buchmäller O.; Dhamotharan S.; Geweniger C.; Graefe G.; Hanke P.; Hansper G.; Hepp V.; Kluge E.; Putzer A.; Sommer J.; Tittel K.; Werner S.; Wunsch M.; Beuselinck R.; Binnie D.; Cameron W.; Dornan P.; Girone M.; Goodsir S.; Martin E.; Moutoussi A.; Nash J.; Sedgbeer J.; Spagnolo P.; Williams M.; Ghete V.; Girtler P.; Kneringer E.; Kuhn D.; Rudolph G.; Betteridge A.; Bowdery C.; Buck P.; Colrain P.; Crawford G.; Finch A.; Foster F.; Hughes G.; Jones R.; Whelan E.; Williams M.; Giehl I.; Hoffmann C.; Jakobs K.; Kleinknecht K.; Quast G.; Renk B.; Rohne E.; Sander H.; van Gemmeren P.; Zeitnitz C.; Aubert J.; Benchouk C.; Bonissent A.; Bujosa G.; Carr J.; Coyle P.; Diaconu C.; Ealet A.; Fouchez D.; Leroy O.; Motsch F.; Payre P.; Talby M.; Sadouki A.; Thulasidas M.; Tilquin A.; Trabelsi K.; Aleppo M.; Antonelli M.; Ragusa F.; Berlich R.; Blum W.; Büscher V.; Dietl H.; Ganis G.; Gotzhein C.; Kroha H.; Lutjens G.; Lutz G.; Mannert C.; Manner W.; Moser H.; Richter R.; Rosado-Schlosser A.; Schael S.; Settles R.; Seywerd H.; Stenzel H.; Wiedenmann W.; Wolf G.; Boucrot J.; Callot O.; Chen S.; Davier M.; Duflot L.; Grivaz J.; Heusse P.; Hücker A.; Jacholkowska A.; Kado M.; Kim D.; Le Diberder F.; Lefrancois J.; Lutz A.; Schune M.; Serin L.; Tournefier E.; Veillet J.; Videau I.; Zerwas D.; Azzurri P.; Bagliesi G.; Bettarini S.; Bozzi C.; Calderini G.; Dell'Orso R.; Fantechi R.; Ferrante I.; Giassi A.; Gregorio A.; Ligabue F.; Lusiani A.; Marrocchesi P.; Messineo A.; Palla F.; Rizzo G.; Sanguinetti G.; Sciabà A.; Sguazzoni G.; Steinberger J.; Tenchini R.; Vannini C.; Venturi A.; Verdini P.; Blair G.; Bryant L.; Chambers J.; Coles J.; Green M.; Medcalf T.; Perrodo P.; Strong J.; von Wimmersperg-Toeller J.; Botterill D.; Clifft R.; Edgecock T.; Haywood S.; Maley P.; Norton P.; Thompson J.; Wright A.; Bloch-Devaux B.; Colas P.; Fabbro B.; Faif G.; Lançon E.; Lemaire M.; Locci E.; Perez P.; Przysiezniak H.; Rander J.; Renardy J.; Rosowsky A.; Roussarie A.; Trabelsi A.; Vallage B.; Black S.; Dann J.; Kim H.; Konstantinidis N.; Litke A.; McNeil M.; Taylor G.; Booth C.; Brew C.; Cartwright S.; Combley F.; Kelly M.; Lehto M.; Reeve J.; Thompson L.; Affholderbach K.; Böhrer A.; Brandt S.; Cowan G.; Foss J.; Grupen C.; Smolik L.; Stephan F.; Apollonio M.; Bosisio L.; della Marina R.; Giannini G.; Gobbo B.; Musolino G.; Putz J.; Rothberg J.; Wasserbaech S.; Williams R.; Armstrong S.; Charles E.; Elmer P.; Ferguson D.; Gao Y.; Gonzalez S.; Greening T.; Hayes O.; Hu H.; Jin S.; McNamara P.; Nachtman J.; Nielsen J.; Orejudos W.; Pan Y.; Saadi Y.; Scott I.; Walsh J.; Sau Lan W.; Wu X.; Yamartino J.; Zobernig G.; Scott I.; Saadi Y.; Sau Lan W.; Walsh J.; Yamartino J.; Wu X.; Zobernig G.; Pan Y.; Barate R.</p
Search for supersymmetry with a dominant R-parity violating LQD̄ coupling in e+e- collisions at centre-of-mass energies of 130 GeV to 172 GeV
No full textcomplete author list: Barate R.; Buskulic D.; Decamp D.; Ghez P.; Goy C.; Jezequel S.; Lees J.; Lucotte A.; Martin F.; Merle E.; Minard M.; Nief J.; Perrodo P.; Pietrzyk B.; Alemany R.; Casado M.; Chmeissani M.; Crespo J.; Delfino M.; Fernandez E.; Fernandez-Bosman M.; Garrido L.; Graugès E.; Juste A.; Martinez M.; Merino G.; Miqnel R.; Mir L.; Morawitz P.; Pacheco A.; Park I.; Pascual A.; Riu I.; Sanchez F.; Colaleo A.; Creanza D.; De Palma M.; Gelao G.; Iaselli G.; Maggi G.; Maggi M.; Nuzzo S.; Ranieri A.; Raso G.; Ruggieri F.; Selvaggi G.; Silvestris L.; Tempesta P.; Tricomi A.; Zito G.; Huang X.; Lin J.; Quyang Q.; Wang T.; Xie Y.; Xu R.; Xue S.; Zhang J.; Zhang L.; Zhao W.; Abbaneo D.; Becker U.; Boix G.; Cattaneo M.; Cerutti F.; Ciulli V.; Dissertori G.; Drevermann H.; Forty R.; Frank M.; Gianotti F.; Hagelberg R.; Halley A.; Hansen J.; Harvey J.; Janot P.; Jost B.; Lehraus I.; Leroy O.; Loomis C.; Maley P.; Mato P.; Minten A.; Moneta L.; Moutoussi A.; Ranjard F.; Rolandi L.; Rousseau D.; Schlatter D.; Schmitt M.; Schneider O.; Tejessy W.; Teubert F.; Tomalin I.; Tournefier E.; Vreeswijk M.; Wachsmuth H.; Ajaltouni Z.; Badaud F.; Chazelle G.; Deschamps O.; Dessagne S.; Falvard A.; Ferdi C.; Gay P.; Guicheney C.; Henrard P.; Jousset J.; Michel B.; Monteil S.; Montret J.; Pallin D.; Perret P.; Podlyski F.; Hansen J.; Hansen J.; Hansen P.; Nilsson B.; Rensch B.; Wäänänen A.; Daskalakis G.; Kyriakis A.; Markou C.; Simopoulou E.; Vayaki A.; Blondel A.; Brient J.; Machefert F.; Rougé A.; Rumpf M.; Tanaka R.; Valassi A.; Videau H.; Focardi E.; Parrini G.; Zachariadou K.; Cavanaugh R.; Corden M.; Georgiopoulos C.; Huehn T.; Jaffe D.; Antonelli A.; Bencivenni G.; Bologna G.; Bossi F.; Campana P.; Capon G.; Chiarella V.; Laurelli P.; Mannocchi G.; Murtas F.; Murtas G.; Passalacqua L.; Pepe-Altarelli M.; Chalmers M.; Curtis L.; Lynch J.; Negus P.; O'Shea V.; Raine C.; Scarr J.; Teixeira-Dias P.; Thompson A.; Thomson E.; Ward J.; Buchmüller O.; Dhamotharan S.; Geweniger C.; Hanke P.; Hansper G.; Hepp V.; Kluge E.; Putzer A.; Sommer J.; Tittel K.; Werner S.; Wunsch M.; Beuselinck R.; Binnie D.; Cameron W.; Dornan P.; Girone M.; Goodsir S.; Marinelli N.; Martin E.; Nash J.; Sedgbeer J.; Spagnolo P.; Williams M.; Ghete V.; Girtler P.; Kneringer E.; Kuhn D.; Rudolph G.; Betteridge A.; Bowdery C.; Buck P.; Colrain P.; Crawford G.; Ellis G.; Finch A.; Foster F.; Hughes G.; Jones R.; Robertson N.; Williams M.; van Gemmeren P.; Giehl I.; Hoffmann C.; Jakobs K.; Kleinknecht K.; Kröcker M.; Nürnberger H.; Quast G.; Renk B.; Rohne E.; Sander H.; Schmeling S.; Zeitnitz C.; Ziegler T.; Aubert J.; Benchouk C.; Bonissent A.; Carr J.; Coyle P.; Ealet A.; Fouchez D.; Motsch F.; Payre P.; Talby M.; Thulasidas M.; Tilquin A.; Aleppo M.; Antonelli M.; Ragusa F.; Berlich R.; Büscher V.; Dietl H.; Ganis G.; Hüttmann K.; Lütjens G.; Mannert C.; Männer W.; Moser H.; Schael S.; Settles R.; Seywerd H.; Stenzel H.; Wiedenmann W.; Wolf G.; Boucrot J.; Callot O.; Chen S.; Davier M.; Duflot L.; Grivaz J.; Heusse P.; H¨ocker A.; Jacholkowska A.; Kado M.; Kim D.; Le Diberder F.; Lefrançois J.; Serin L.; Veillet J.; Videau I.; de Vivie de Régie J.; Zerwas D.; Azzurri P.; Bagliesi G.; Bettarini S.; Boccali T.; Bozzi C.; Calderini G.; Dell'Orso R.; Fantechi R.; Ferrante I.; Giassi A.; Gregorio A.; Ligabue F.; Lusiani A.; Marrocchesi P.; Messineo A.; Palla F.; Rizzo G.; Sanguinetti G.; Sciab`a A.; Sguazzoni G.; Tenchini R.; Vannini C.; Venturi A.; Verdini P.; Blair G.; Chambers J.; Coles J.; Cowan G.; Green M.; Medcalf T.; Strong J.; von Wimmersperg-Toeller J.; Botterill D.; Clifft R.; Edgecock T.; Norton P.; Thompson J.; Wright A.; Bloch-Devaux B.; Colas P.; Fabbro B.; Faif G.; Lançon E.; Lemaire M.; Locci E.; Perez P.; Przysiezniak H.; Rander J.; Renardy J.; Rosowsky A.; Trabelsi A.; Tuchming B.; Vallage B.; Black S.; Dann J.; Kim H.; Konstantinidis N.; Litke A.; McNeil M.; Taylor G.; Booth C.; Cartwright S.; Combley F.; Kelly M.; Lehto M.; Thompson L.; Affholderbach K.; Böohrer A.; Brandt S.; Foss J.; Grupen C.; Prange G.; Smolik L.; Stephan F.; Giannini G.; Gobbo B.; Putz J.; Rothberg J.; Wasserbaech S.; Williams R.; Armstrong S.; Charles E.; Elmer P.; Ferguson D.; Gao Y.; González S.; Greening T.; Hayes O.; Hu H.; Jin S.; McNamara P.; Nachtman J.; Nielsen J.; Orejudos W.; Pan Y.; Saadi Y.; Scott I.; Walsh J.; Wu S.; Wu X.; Zobernig G.; Barate R.; Buskulic D.; Zobernig G.; Pan Y.; Saadi Y.; Nielsen J.; Orejudos W.; Wu S.; Wu X.; Scott I.; Walsh J.; Hayes O.; Greening T.; González S.; Gao Y.; Nachtman J.; McNamara P.; Jin S.; Hu H.; Ferguson D.; Elmer P.; Charles E.; Barate R.</p
Overexpression of MtTdp2alpha (Tyrosyl-DNA phosphodiesterase 2alpha) gene in Medicago truncatula Gaertn. is associated with up-regulation of DNA repair and ROS scavenger genes and structural changes in nucleolar architecture
No full text- …
