238 research outputs found
Revolutionizing Plastic Waste Management: Fuel Production from Discarded Plastics
Get PDFThe startling acceleration in the amount of pollution caused by plastic rubbish has created a significant ecological issue on a scale that encompasses the entire planet. This study presents a comprehensive analysis of the process of reverse engineering, which is utilized in the conversion of unwanted plastic waste into beneficial fuel products. Pyrolysis and catalytic conversion are two examples of modern technologies for thermally degrading waste plastic, and both of these processes result in the production of fuels generated from hydrocarbons as well as other valuable byproducts. This study aims to increase the generation of fuel in terms of both quantity and quality. To accomplish this, it will investigate ways in which operational parameters, catalysts, and feedstock sources can be adjusted. In addition, the economic and environmental effects of the novel method are analyzed, with a particular focus on lowering the amount of pollution caused by plastic and increasing the production of renewable energy. The findings of the study emphasize the practicability and potential of changing plastic trash into viable fuels. This is a sustainable resolution to global energy and environmental challenges, and the findings also highlight the promise of this solution. We want to emphasize how important it is to conduct continual research and development in this field in order to support the extension of these processes for general acceptance and to contribute in the construction of a future that is environmentally conscientious and sustainable. To summarize, the findings of this study indicate the possibility of employing waste plastic in the production of valuable fuel commodities. This would both address environmental concerns and provide a solution that is both practical and effective to the problem of waste plastic. This is a great resource for policymakers, scientists, and businesses that are looking for long-term answers to the problems of managing plastic trash and producing energy
HOXA1-stimulated oncogenicity is mediated by selective upregulation of components of the p44/42 MAP kinase pathway in human mammary carcinoma cells
No full textExpression of homeobox A1 (HOXA1) results in oncogenic transformation of immortalized human mammary epithelial cells with aggressive tumor formation in vivo. However, the mechanisms by which HOXA1 mediates oncogenic transformation is not well defined. To identify molecules that could potentially be involved in HOXA1-mediated oncogenic transformation, microarray analysis was utilized to characterize and compare the gene expression pattern in response to forced expression or depletion of HOXA1 in human mammary carcinoma cells. Gene expression profiling identified that genes involved in the p44/42 mitogen-activated protein (MAP) kinase activation pathway (GRB2, MAP kinase kinase (MEK1) and SDFR1) or p44/42 MAP kinase-regulated genes (IER3, EPAS1, PCNA and catalase) are downstream expression targets of HOXA1. Forced expression of HOXA1 increased GRB2 and MEK1 mRNA and protein expression and increased p44/42 MAP kinase phosphorylation, activity and Elk-1-mediated transcription. Use of a MEK1 inhibitor demonstrated that increased p44/42 MAP kinase activity is required for the HOXA1-mediated increase in cell proliferation, survival, oncogenicity and oncogenic transformation. Thus, modulation of the p44/42 MAP kinase pathway is one mechanism by which HOXA1 mediates oncogenic transformation of the human mammary epithelial cell
HOXA1 is required for E-cadherin-dependent anchorage-independent survival of human mammary carcinoma cells
Get PDFForced expression of HOXA1 is sufficient to stimulate oncogenic transformation of immortalized human mammary epithelial cells and subsequent tumor formation. We report here that the expression and transcriptional activity of HOXA1 are increased in mammary carcinoma cells at full confluence. This confluence-dependent expression of HOXA1 was abrogated by incubation of cells with EGTA to produce loss of intercellular contact and rescued by extracellular addition of Ca2+. Increased HOXA1 expression at full confluence was prevented by an E-cadherin function-blocking antibody and attachment of non-confluent cells to a substrate by homophilic ligation of E-cadherin increased HOXA1 expression. E-cadherin-directed signaling increased HOXA1 expression through Rac1. Increased HOXA1 expression consequent to E-cadherin-activated signaling decreased apoptotic cell death and was required for E-cadherin-dependent anchorage-independent proliferation of human mammary carcinoma cells. HOXA1 is therefore a downstream effector of E-cadherin-directed signaling required for anchorage-independent proliferation of mammary carcinoma cells
The effects of aging and dual task performance on language production
Get PDFThis is an electronic version of an article published in Kemper, S., Schmalzried, R., Herman, R., Leedahl, S., & Mohankumar, D. (2009). The effects of aging and dual task performance on language production. Aging, Neuropsychology, and Cognition, 16, 241-259. PM#2674132. Aging, Neuropsychology, and Cognition
is available online at www.taylorandfrancis.comA digital pursuit rotor task was used to measure dual task costs of language production by young and older adults. After training on the pursuit rotor, participants were asked to track the moving target while providing a language sample. When simultaneously engaged, young adults experienced greater dual task costs to tracking, fluency, and grammatical complexity than older adults. Older adults were able to preserve their tracking performance by speaking more slowly. Individual differences in working memory, processing speed, and Stroop interference affected vulnerability to dual task costs. These results demonstrate the utility of using a digital pursuit rotor to study the effects of aging and dual task demands on language production and confirm prior findings that young and older adults use different strategies to accommodate to dual task demands
Microstructure and mechanical properties of nickel coated multi walled carbon nanotube reinforced stainless steel 316L matrix composites by laser sintering process
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An aqueous extract of Curcuma longa (turmeric) rhizomes stimulates insulin release and mimics insulin action on tissues involved in glucose homeostasis in vitro
No full textAnthocyanin modified triphenylamine based organic sensitizer for dye sensitized solar cells (DSSC) - A theoretical approach
No full textAge-based differences in care setting transitions over the last year of life
Get PDFContext. Little is known about the number and types of moves made in the last year of life to obtain healthcare and end-of-life support, with older adults more vulnerable to care setting transition issues. Research Objective. Compare care setting transitions across older (65+ years) and younger individuals. Design. Secondary analyses of provincial hospital and ambulatory database data. Every individual who lived in the province for one year prior to death from April 1, 2005 through March 31, 2007 was retained (N = 19, 397). Results. Transitions averaged 3.5, with 3.9 and 3.4 for younger and older persons, respectively. Older persons also had fewer ER and ambulatory visits, fewer procedures performed in the last year of life, but longer inpatient stays (42.7 days versus 36.2 for younger persons). Conclusion. Younger and older persons differ somewhat in the number and type of end-of-life care setting transitions, a matter for continuing research and healthcare policy
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