4,337 research outputs found
Decarboxylative Suzuki-Miyaura Coupling of (hetero)aromatic carboxylic acids using Iodine as the Terminal Oxidant
No full textA novel methodology for the decarboxylative Suzuki-Miyaura-type coupling has been established. This process uses iodine or a bromine source as both the decarboxylation mediator and the terminal oxidant, thus avoiding the need for stoichiometric amounts of transition metal salts previously required. Our new protocol allows for the construction of valuable biaryl architectures through the coupling of (hetero)aromatic carboxylic acids with arylboronic acids. The scope of this decarboxylative Suzuki reaction has been greatly diversified, allowing for previously inaccessible non-ortho-substituted aromatic acids to undergo this transformation. The procedure also benefits from low catalyst loadings and the absence of stoichiometric transition metal additives
The use of carboxylic acids as traceless directing groups for regioselective C-H bond functionalisation
No full textThe ability to selectively functionalise a specific C-H bond is a long-standing challenge due to the ubiquity of such bonds in organic molecules. One of the most common approaches to overcome this obstacle consists of installing directing groups into substrates to direct the functionalisation towards the desired C-H bond, leaving behind the directing group in the molecule. Alternatively, carboxylic acids have been employed as traceless directing groups that are easily removed after carboxylic acid-directed installation of the desired functionality. This review focuses on the development of this concept and its application to organic synthesis during the last decade.</p
Jacob of Sarug's Homily on Tamar (Gen 38)
No full textThis small volume contains an edition (from Vatican ms. 117) of Jacob of Sarug’s homily on Tamar (420 lines long). The full title is “On Tamar and on the Mystery of the Church.” The biblical narrative on which the poem is based (Gen 38) gives Jacob the opportunity to discuss various women in the early part of biblical history and in Jesus’ lineage, as well as the fact that a woman who is called a prostitute is in that lineage. Jacob explains how Scripture’s language is used in this regard
Jacob Wassermann.
No full textOne of several renderings of the German author Jacob Wassermann by the painter and illustrator Suzanne Carvallo-Schülein.Digital ImageArtwork
Jacob of Serugh's Homilies on the Spectacles of the Theatre
No full textThis fascinating volume contains excerpts from four otherwise unedited (and untranslated) homilies from Jacob of Sarug on the theatre. These homilies, extant only in a single manuscript (BM Add. 17158), which is unfortunately poorly preserved, are unique for the light they cast on the Greek theatre in the Byzantine period. In this article, originally published in Le Muséon 48 (1935), Moss gives a substantive introduction to the selections presented from these homilies, and then presents the texts in Syriac and in English translation. Scholars and readers interested in Syriac literature, and in Jacob of Sarug in particular, as well as students of the history of the theatre, will find this work of great interest.Translated into English from the Syriac text
Transition Metal-Free Decarboxylative Iodination:New Routes for Decarboxylative Oxidative Cross-Couplings
No full textConstructing products of high synthetic value from inexpensive and abundant starting materials is of great importance. Aryl iodides are essential building blocks for the synthesis of functional molecules and efficient methods for their synthesis from chemical feedstocks are highly sought after. Here we report a low-cost decarboxylative iodination that occurs simply from readily available benzoic acids and I2. The reaction is scalable and the scope and robustness of the reaction is thoroughly examined. Mechanistic studies suggest that this reaction does not proceed via a radical mechanism, which is in contrast to classical Hunsdiecker-type decarboxylative halogenations. In addition, DFT studies allow comparisons to be made between our procedure and current transition metal-catalyzed decarboxylations. The utility of this procedure is demonstrated in its application to oxidative cross-couplings of aromatics via decarboxylative/C–H or double decarboxylative activations that use I2 as the terminal oxidant. This strategy allows the preparation of biaryls previously inaccessible via decarboxylative methods and holds other advantages over existing decarboxylative oxidative couplings as stoichiometric transition metals are avoided
Transition-Metal-Free Decarboxylative Bromination of Aromatic Carboxylic Acids
No full textMethods for the conversion of aliphatic acids to alkyl halides have progressed significantly over the past century, however, the analogous decarboxylative bromination of aromatic acids has remained a longstanding challenge. The development of efficient methods for the synthesis of aryl bromides is of great importance as they are versatile reagents in synthesis and are present in many functional molecules. Herein we report a transition metal-free decarboxylative bromination of aromatic acids. The reaction is applicable to many electron-rich aromatic and heteroaromatic acids which have previously proved poor substrates for Hunsdiecker-type reactions. In addition, our preliminary mechanistic study suggests that radical intermediates are not involved in this reaction, which is in contrast to classical Hunsdiecker-type reactivity. Overall, the process demonstrates a useful method for producing valuable reagents from inexpensive and abundant starting materials
Jacob Viner’s Reminiscences from the New Deal (February 11, 1953)
No full textThis paper presents and reproduces an unpublished oral history interview given by Jacob Viner in 1953. The interview released by Viner for the Columbia Oral History Project gives us a valuable opportunity to throw light on his advisory activity during the New Deal Era. In our introduction we attempt to make a critical appraisal of Viner's reminiscences and to state the contribution they can provide to our general knowledge of the period. In addition, we also attempt to find out some biographical and interpretative elements useful to understand Viner’s own vision and his contribution to important economic policy processes during the New Deal.
Jacob of Serugh on the Eucharist: Homilies 22 and 95
No full textIn the two articles reprinted here, Dom Hugh Connolly offers an English translation of two homilies from Jacob of Serugh dealing with the Eucharist. Connolly used the Syriac text of Bedjan’s edition of Jacob’s homilies (also available from Gorgias Press), homilies 22 and 95 in that edition. A short selection from homily 53 is also translated because of its related subject matter. Connolly gives an introduction to each homily and includes some explanatory notes to the texts. These translations originally appeared in The Downside Review, nos. 27 (1908) and 29 (1910).Translated into English from the Syriac text of Bedjan’s edition of Jacob’s homilies.These translations originally appeared in The Downside Review, nos. 27 (1908) and 29 (1910)
Gebißbuch Oder Kurtzer und Gründlicher Bericht/ von Gebiß und Zeumung der Pferd : sampt deroselben unterschiedlichen Würckung/ auch wie dieselben nützlich und nach gelegenheit der Pferde zugebrauchen sein / Allen ... Standes Personen/ und dieser Kunst Liebhabern zu Ehren ... verfaßt/ und in offnen Druck gegeben/ Durch Christoff Jacob Lieb
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