186 research outputs found
Design of high frequency ultrasonic array transducers for medical imaging
No full textUltrasonic transducers have been widely used in the medical applications. High frequency array transducers have recently attracted many research interests, since it provides not only the electronic beamforming but also the very fine image resolution. The transducers are usually either annular or linear arrays. This study concentrates on the design of both types of array in high frequency applications.The annular array is firstly investigated, and an optimized design of array geometry is developed including the kerfs influence which is usually neglected in the design of high frequency arrays. The improved imaging performance is found by this optimized design. More interestingly, the conventional annular array with element having the same surface area has a relatively large sidelobe closest to the main lobe. Two methods are applied to suppress the sidelobe. The method of using high-impedance single matching to enlarge the element bandwidth only shows very limited lobe suppression, however, a novel matching approach is found. Another method of changing the array geometry from equal area elements to equal width ones successfully suppressed the sidelobe. The imaging results suggest that the novel equal width array shows a good improvement.The linear array is then analyzed. The kerfs influence again is found to be significant for the array especially for high frequency. It is essential to use a high attenuated kerfs material in the linear array design. More importantly, the limitation of current fabrication techniques forces the linear array to concede a high grating lobe in the imaging field if it operates in a relatively high frequency. A novel linear array is developed to suppress the grating lobe without using advanced fabrication techniques. The imaging results show that the novel linear array has a general reduction of -6dB for the lobe suppression. The novel design made the linear array operate in a very high frequency without strong grating lobe, and the array can be fabricated by current techniques
Raw Data for "On-demand cell-autonomous gene therapy for brain circuit disorders", Qiu et al. 2022 Science
No full textRaw Data for Qui et al. 2022 10.1126/science.abq6656
On-demand cell-autonomous gene therapy for brain circuit disorders
Yichen Qiu, Nathanael O’Neill, Benito Maffei, Clara Zourray, Amanda Almacellas Barbanoj, Jenna C. Carpenter,Steffan P. Jones, Marco Leite, Thomas J. Turner, Francisco C. Moreira, Albert Snowball, Tawfeeq Shekh-Ahmad, Vincent Magloire, Serena Barral, Manju A. Kurian, Matthew C. Walker, Stephanie Schorge, Dimitri M. Kullmann, Gabriele Lignani
Content:
EEG
MEA
Immuno
Patch Clamp Electrophysiology
All data are in a open source format. MEA files can be analysed using the MATLAB-based developed by Prof Michela Chiappalone and requests should be direct to:
Michela Chiappalone [email protected]
Ilaria Colombi [email protected]
EEG files are .zip with different transmitters. See EEG_Keys.xlxs for whcih virus was used in each animal.
MEA files are divided in 2 separate .zip: 1. Fig2 and Fig S3 and S7. 2. Fig S6.
Immuno: all the raw images are in the .zip file seprated by Figure #
Patch Clamp Electrophysiology: all the raw .abf files are in the .zip file separated by Figure #
For more info or to request materials please contact the corrsponding author Gabriele Lignani [email protected]
</p
What Is an Author's Role in the AI Era? Demystifying the Black Box of Human-AI Collaborative Creation Through an "Aesthetic Judgment" Study of the novel Solid Reference Frame Manuscript
No full textThis project repository establishes a permanent timestamp for a study that rethinks Roland Barthes' proclamation of the "death of the author" for the AI era. It engages with Michel Foucault's concept of "author-function" to propose "Aesthetic Judgment" as a new theoretical framework for human-AI collaborative creation. This framework reconceptualizes AI as a "critical partner"—a source of provocation and challenge. The human author, in turn, exercises decisive curatorial power through four key operations: 1) The Right to Question, 2) The Right to Select, 3) The Right to Arbitrate, and 4) The Right to Integrate.
Employing a "Process-Tracing" methodology, the research analyzes the complete manuscript of the novel Solid Reference Frame to demystify the creative "black box." This empirical study aims to demonstrate how the human author's role is transformed from a solitary genius into a systemic architect of meaning, thereby asserting a new, viable author-function for the digital age
Tailored family adaptation to living in a zero-energy house: Occupant’s crises and conflicts with a heat pump-based system
No full textBackgroundThis project belongs to the IEBB project, which advocates for the renovation of ‘zero energy houses’ (ZEH) that synergize insulation and heat pump systems for energy conservation. The ZEH’s energy-saving efficiency depends on user behaviour. From a systems perspective, improper human interactions hinder energy saving, while occupants may find system responses that conflict with their preferences. This study delves into these conflicts and crises, highlighting the variance in post-occupancy adaptation influenced by individual perceptions and familial interplay. The project’s zenith aim is to tailor adaptation, ensuring co-performance between the heat pumpsystem and households. Key InsightIn researching residents’ responses to the ‘routine crisis’ introduced by a new system, I discovered that these ‘crises’ could be productive, stimulating household engagement and fostering harmonious interactions with ZEH systems. This insight gave rise to the concept of the ‘enacted interface’ - a distinctive bridge between residents and their automated homes that supports the adaptation process. Through analysis, I identified elements that amplify residents’ engagement with ‘crises’ and observed the influence of family diversity on individual perceptions and responses to them. The results are manifested in two interrelated frameworks: one describing the ubiquity of ‘crises’ and another characterising the classification and impact of different elements.DesignThis design aims to make households curious about ‘crises’ and guide them towards tailored adaptations to new tech. The ‘Clock’ thermostat provides a consistent interface for temperature adjustments, while the ‘Feeling Message Board’ suggests lifestyle tips based on the user’s emotional input and changing scenarios. Both reinforce the system’s ability to communicate contextual and real-time status, motivating users to actively engage with its functions. Additionally, the design stimulates family discussions about the indoor environment and promotes collaborative responses to ‘crises’. Through co-performance of the system’s dynamic feedback and the household’s proactive exploration, the aim is to facilitate tailored adaptation.IEBB projectIntegrated Product Desig
Modeling Dengue Virus-Hepatic Cell Interactions Using Human Pluripotent Stem Cell-Derived Hepatocyte-like Cells
No full textSummaryThe development of dengue antivirals and vaccine has been hampered by the incomplete understanding of molecular mechanisms of dengue virus (DENV) infection and pathology, partly due to the limited suitable cell culture or animal models that can capture the comprehensive cellular changes induced by DENV. In this study, we differentiated human pluripotent stem cells (hPSCs) into hepatocytes, one of the target cells of DENV, to investigate various aspects of DENV-hepatocyte interaction. hPSC-derived hepatocyte-like cells (HLCs) supported persistent and productive DENV infection. The activation of interferon pathways by DENV protected bystander cells from infection and protected the infected cells from massive apoptosis. Furthermore, DENV infection activated the NF-κB pathway, which led to production of proinflammatory cytokines and downregulated many liver-specific genes such as albumin and coagulation factor V. Our study demonstrates the utility of hPSC-derived hepatocytes as an in vitro model for DENV infection and reveals important aspects of DENV-host interactions
The Effectiveness and Issues of Using Feedback in Second Language Writing
No full textBased on the description of feedback in the literature and the classification of feedback by different scholars, this paper discusses the efficiency and possible issues of the teachers’ use of different feedback in the teaching of second language writing. Through interviews with experienced English majors, this paper further demonstrates the importance of teachers' use of feedback in second language writing teaching. At the end of the paper, the author also shows that the combination of different feedback according to specific situations in teaching can better promote the writing proficiency of second language learners
Author Correction: Transiting consolidated ice strongly influenced polynya area during a shrink event in Terra Nova Bay in 2013
No full textIn this article the author name Matthew Mazloff was incorrectly written as Matthew Mazloeff. The original article has been corrected
Thermomechanical Oriented Reliability Enhancement of Si MOSFET Panel-Level Packaging Fusing Ant Colony Optimization With Backpropagation Neural Network
No full textConsiderable advancements in power semiconductor devices have resulted in such devices being increasingly adopted in applications of energy generation, conversion, and transmission. Hence, we proposed a fan-out panel-level packaging (FOPLP) design for 30-V Si-based metal-oxide-semiconductor field-effect transistor (MOSFET). To achieve superior reliability of packaging, we applied the nondominated sorting genetic algorithm with elitist strategy (NSGA-II) and ant colony optimization-backpropagation neural network (ACO-BPNN) to optimize the design of redistribution layer (RDL) in FOPLP. We first quantified the thermal resistance and thermomechanical coupling stress of the designed package under thermal cycling loading. Next, NSGA-II and ACO-BPNN were used to optimize the size of the RDL blind via. Finally, the effectiveness of the proposed reliability optimization methods was verified by performing thermal shock reliability aging tests on the prepared devices.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic Components, Technology and Material
"Yi tiao bian fa" de kai duan?: shi wu shi ji shang ban ye cai zheng gai ge de li lun yu xian shi = The beginning of “The single whip” reform? : theory and reality of the fiscal reform in fifteenth century China
No full textM.Phil.The so-called “Single-whip Reform” (Itiaobian fa) was a reform of tax collection in mid-Ming China. Though the detail of the reform remains obscure, historians consider that it contained two common features. Firstly, different kinds of labor services were combined into a single item of tax and levied on land. Secondly, the payment of the tax became silver.When it came to the origin of the Reform, historians always went back to the fifteenth century, thought the measures such as “Equalization of grain” (Pingmi Fa) or “Equalization of labor services” were the prelude of the Single-whip. Instead of using the beginning of the Single Whip Reform to identified the fifteenth century's fiscal reform, this dissertation gives a detailed description of how the Ming government handled its fiscal hardships in the beginning of the fifteenth century.The shift of the imperial capital from Nanjing to Beijing in 1421 disrupted the tax collection process in the early Ming. To deal with the high transportation cost from the lower Yangtze region to Beijing, the magistrates replaced civilian tax farmers to take charge of grain tax transport. And in order to deliver more revenue to Beijing, the Court decided to allow taxpayer pay part of their grain tax in silver or cloth.By documenting these changes and their influence, we will reconsideration the conception of the Single-Whip Reform at the end of the dissertation.十六世紀明代出現了官府將賦稅和徭役合併用銀兩計算，然後再將之編派到地畝和人丁數字之上的賦役變革。這一被稱為“一條鞭法”的改革，被學者們視為王朝財政體系的重大轉折，直接形塑了此後幾個世紀中國的財稅結構。在探究“一條鞭法”出現緣起時，以往的學者多以“由役入賦”和“銀納化”兩個特徵為切入點，將十五世紀上半葉稅役徵派方式的一系列變化視為“一條鞭法”的先聲。本文正是要探討為何這些轉折會集中出現在宣德（1426-1435）、正統（1436-1449）年間，以及它們究竟帶來了哪些改變。本文認為，永樂年間都城的北遷，導致原本圍繞南京佈置的稅收解運體系陷入危機，成為宣德、正統年間財稅體系大規模變動的直接原因。因為糧長無力擔保稅長途解運所產生的費用與風險，官府調整了原本以糧長委任為核心的稅糧徵解方法。徵收在介入稅糧遠運費用的管理中，蘇松地區以府縣衙門為核心的賦役派徵體系逐步建立起來。在稅糧高額逋欠的狀況緩解之後，運河運糧能力的瓶頸又凸顯出來，促動了朝廷以折徵部分稅糧的方式換取財政資源的北運。這一折徵令間接地令白銀成為合法的稅收形態，從而令官府以白銀為單位編修賦役文冊成為可能。劉怡辰.Parallel title from English abstract.Thesis M.Phil. Chinese University of Hong Kong 2017.Includes bibliographical references (leaves 90-100).Abstracts in English and Chinese.Title from PDF title page (viewed on February 18, 2020).Liu Yichen
Genetic Algorithm–Assisted Design of Redistribution Layer Vias for a Fan-Out Panel-Level SiC MOSFET Power Module Packaging
No full textA fan-out panel-level packaging (FOPLP) with an embedded redistribution layer (RDL) via interconnection reduces the size, thermal resistance, and parasitic inductance of power module packaging. In this study, the effect of the RDL via size on the reliability of a FOPLP SiC MOSFET power module was investigated. To improve the thermal management and thermal cycling reliability of the designed SiC module, genetic algorithm (GA)–assisted optimization methods were proposed to optimize the RDL via size. First, the heat dissipation and the plastic work density of the SiC MOSFET module with various via diameters and depths were simulated using finite element simulations. Next, both the ant colony optimization-backpropagation neural network (ACOBPNN) with finite element simulation and the nondominated sorting genetic algorithm (NSGA-II) with theoretical model were developed to optimize the RDL via size. The results revealed that: (1) smaller via depth and size reduce the heat dissipation and thermal cycling reliability of the RDL via; (2) through both the ACO-BPNN and NSGA-II, the same optimal heat dissipation and plastic work density can be achieved in the designed module. (3) ACO-BPNN with assist of finite element simulation can provide a more effective optimization in complex packaging structure.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic Components, Technology and Material
- …
