57 research outputs found
Mimicking the 2-oxoglutaric acid signalling function using molecular probes: insights from structural and functional investigations
No full text2-Oxoglutaric acid (2-OG) has gained considerable attention because of its newly discovered signalling role in addition to its established metabolic functions. With the aim of further exploring the signalling function of 2-OG, here we present a structure-activity relationship study using 2-OG probes bearing different carbon chain lengths and terminal groups. Our results highlight the importance of the five-membered carbon molecular skeleton and of the two carboxylic terminals in maintaining the signalling functions of the parent molecule 2-OG. These findings provide valuable information for designing new, effective molecular probes able to dissect and discriminate the newly discovered, complex signalling role of 2-OG from its canonical activity in metabolism
4-Nitrophenyl N-phenylcarbamate
No full textThe title compound, C13H10N2O4, was synthesized as an intermediate for the preparation of ureas. The two aromatic rings are twisted about the central carbamate group with a C—C—N—C torsion angle of 139.6 (2)° and a C—C—O—C torsion angle of 95.9 (2)°. The molecules are linked into one-dimensional chains by N—H...O hydrogen bonds along the b axis. Weak interactions between O atoms of the nitro groups (O...O = 3.012 Å) connect two adjacent chains
4-Nitrophenyl methacrylate
No full textThe title compound, C10H9NO4, was obtained serendipitously during the preparation of benzyl cyclohexylcarbamate. The molecule consists of two approximately planar parts, the nitrophenyl ring and the rest of the non-H atoms, with a dihedral angle of 55.05 (6)° between the two segments. The crystal structure is stabilized by weak C—H...O interactions and π stacking [3.753 (1) Å] along the b axis
2-Chloro-4-iodoaniline
No full textThe title dihaloaniline, C6H5ClIN, shows no significant hydrogen bonds nor the commonly observed I...I interactions in the crystal structure, although an amino group and an I atom are available for such contacts. The crystal structure is stabilized by weak interactions involving the amine functionality as donor group and N or halogen atoms as acceptors
Choosing Healthy Food in Sydney's Inner City Neighborhoods
No full textAbstractDiet-related chronic diseases are a major health problem faced by developed and developing countries. Although individuals’ dietary patterns are often associated with varied psychological and socioeconomic factors, built environment factors can be important determinants of food choices. Whilst there is some evidence to suggest a link between access to food and food consumption, it remains unclear how a wider range of built environment factors influence residents’ food choices. A deeper understanding of these relationships could reveal under-researched aspects of a healthy built environment. This paper explores how residents in inner Sydney neighborhoods access food and investigates how characteristics of the built environment influence their food choices. Eighteen participants, representing a range of ethnic backgrounds and levels of income, were selected for in-depth interviews. Several urban barriers to healthy food consumption were identified through analysis. Distance, land use and urban form, in particular, shape the food choices of individuals in different ways. These findings have implications for urban planning and policy making for healthy cities
ChemInform Abstract: A Facile Method for the Synthesis of Hepta‐O‐acetyl‐β‐D‐lactosyl Substituted Benzoates.
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4-Fluoro-2,2′-bipyridine (fbpy) complexes of cobalt(II/III) and iron(II/III) and electron transfer in the Co(bpy)32+–Co(fbpy)33+ system
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