16 research outputs found
“Aracneidismo y ofidismo por bothrops: Una Revisión Bibliográfica”
No full textLos animales ponzoñosos son aquellos que tienen glándula productora de veneno y capacidad de inyectarlo. En esta revisión se abarca sobre arácnidos y serpientes de importancia epidemiológica, ambiental y médico, debido a las potenciales consecuencias que producen, por esto se busca dar a conocer una idea general de las manifestaciones clínicas y un tratamiento rápido y eficaz que pueda disminuir los riesgos que representan para la salud de las personas
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I see where you are going: Perception of persuasion goals in moral narratives influences character impressions
No full textImpressions of others’ moral character are key to our social lives, but we rarely directly witness immoral acts, and rather rely on the stories we hear. This creates significant opportunities for narrators to distort their stories in an effort to appear more moral. How does the detection of such persuasion goals affect readers' impressions of the authors' character? Participants read autobiographical stories written by other participants about morally questionable actions they did – written once with no goal, and then again with the goal of appearing morally good or bad. Readers were very accurate in detecting the authors’ goals, but these were nonetheless effective in modulating character impressions. Critically, this effect vanished when readers thought the author didn't care about communicating information accurately. This suggests that audiences sometimes fail to discount narrators' goals when evaluating their character, but only when goals don't come at the cost of communicating information accurately
Utility privatization and the needs of the poor in Latin America - Have we learned enough to get it right?
No full textEfforts to reform utilities can affect poor households in varied, often complex, ways, but it is by no means certain that such reform will hurt vulnerable households. Many myths have been perpetuated in discussions of utility reform - and in many cases poor households have benefited from reform. What is amazing is the extent to which governments, and their advisors - sometimes including multilateral organizations - fail to measure, anticipate, and monitor how the privatization of utilities actually affects the poor. Many questions must still be answered before good general guidelines can be drawn, but the authors offer many suggestions about how social, regulatory, and privatization policy, can increase the benefits of utility reform for poor households. The good news is that many measures can be taken to improve the chances that poor households will benefit from reform. Chief among these is promoting competition, where possible. Essentially what is needed is political commitment to doing the right thing. If policy is weak before privatization, it is going to be weak after privatization as well. Privatization is no substitute for responsible policy on redistribution.Environmental Economics&Policies,Trade Finance and Investment,Municipal Financial Management,Decentralization,Banks&Banking Reform,Environmental Economics&Policies,Banks&Banking Reform,Public Sector Economics&Finance,Town Water Supply and Sanitation,Municipal Financial Management
The lender of last resort function under a currency board : the case of Argentina
No full textWithin the current rules of the game, Argentina's central bank (BCRA) is charged with being the lender of last resort as well as providing full convertibility between pesos and U.S. dollars - two objectives with one instrument, namely, reserves. Within those rules, it may be well that the balance of responsibilities needs to shift. Complete dollarization can significantly reduce risks but not entirely eliminate them. If the BCRA can concentrate more on building up reserves and helping to ward off crises of confidence in the currency, perhaps the banking system can protect itself better from liquidity shocks. But this will require, among other things, consolidation of the sector (which could give it greater access to outside liquidity) and prudential strengthening of the system. Triage of weaker banks should continue and not await another crisis. More experience with the new liquidity policy is needed and so is reform of the settlement system, as it affects the functioning of the interbank market, which is essential for containing crises. Essentially, however, no grand solution seems to exist for the problems that seem inevitable in a system where the central bank is also the currency board. Argentina's strategy must therefore turn on actively strengthening its banking systems to reduce the risks of insolvency.Financial Intermediation,Payment Systems&Infrastructure,Banks&Banking Reform,Financial Crisis Management&Restructuring,Economic Theory&Research,Banks&Banking Reform,Financial Intermediation,Financial Crisis Management&Restructuring,Economic Theory&Research,Banking Law
Medición de actividad física en adolescentes, cuestionario Youth activity profile-spain durante el confinamiento, Chia 2020
No full textIntroducción: El Covid-19 ha traído periodos de confinamiento que han afectado los niveles de actividad física en adolescentes. Recientes estudios han determinado un descenso en la práctica de actividad física y un aumento en el comportamiento sedentario. Objetivo: Establecer los niveles de actividad física en adolescentes del municipio de Chía-Cundinamarca a través del cuestionario Youth Activity Profile-Spain durante el confinamiento del 2020. Materiales y métodos: Investigación con enfoque cuantitativo, a partir de un diseño no experimental y de tipo descriptivo a través del cuestionario autoadministrado YAP-S en formato virtual aplicado durante el periodo de confinamiento del 2020. 112 adolescentes de 12 a 17 años (56,25% femenino, 43,75% masculino) del municipio de Chía-Cundinamarca. Se registraron variables como: actividad física dentro y fuera de la jornada escolar, comportamiento sedentario, edad, peso, talla e índice de masa corporal. Se empleó el software R Studio y medidas de tendencia central para el análisis estadístico. Resultados: El 100% de los adolescentes reporta una actividad física mayor a 600 METs en una semana y un IMC normal. Se identificó una intensidad horaria en ambos géneros de más de 4 horas al día de uso de dispositivos electrónicos. Conclusiones: Los adolescentes de Chía-Cundinamarca presentan un nivel de actividad física moderado durante el confinamiento de 2020 cumpliendo con las recomendaciones de la OMS. A pesar del contexto en el cual se desarrolla este estudio, los adolescentes mantienen una práctica regular de actividad física.Introduction: Covid-19 has brought periods of confinement that have affected physical activity levels in adolescents. Recent studies have determined a decrease in the practice of physical activity and an increase in sedentary behavior. Objective: To establish physical activity levels in adolescents of the municipality of Chía-Cundinamarca through the Youth Activity Profile-Spain questionnaire during confinement of 2020. Materials and methods: Research with a quantitative approach, from a non-experimental and descriptive design through the YAP-S self-administered questionnaire in virtual format applied during the confinement period of 2020. 112 adolescents aged 12 to 17 years (56.25% female, 43.75% male) from the municipality of Chía-Cundinamarca. Variables such as: physical activity inside and outside the school day, sedentary behavior, age, weight, height and body mass index were recorded. The R Studio software and central tendency measures were used for statistical analysis. Results: 100% of adolescents report a physical activity greater than 600 METs in one week and a normal BMI. An hourly intensity in both genders of more than 4 hours a day of use of electronic devices was identified. Conclusions: Adolescents from Chía-Cundinamarca present a moderate level of physical activity during the 2020 confinement, complying with the WHO recommendations. Despite the context in which this study is developed, adolescents maintain a regular practice of physical activity.Incluye bibliografíaPregradoProfesional en Ciencias del DeporteCiencias del Deport
Defect evolution during annealing of deformed FeSi alloys studied by positron annihilation spectroscopy
No full textHigh silicon steel is widely used in electrical appliances. Alloying iron with silicon improves its magnetic performance. A silicon content up to 6.5 wt. % gives excellent magnetic properties such as high saturation magnetization, near zero magnetostriction and low iron loss in high frequencies. Their workability is greatly reduced by the appearance of ordered structures, namely B2 and D03, as soon as the Si content becomes higher than 3.5 wt. %. This limits the mass production by conventional rolling to this maximum percentage of Si. In this work a series of FeSi (7.5 wt. % Si) samples with different degrees of deformation are investigated with positron annihilation spectroscopy and optical microscopy (OM). The influence of annealing on the concentration of defects of different deformed FeSi alloys has been investigated by positron annihilation lifetime spectroscopy and Doppler broadening of the annihilation radiation. OM is used to investigate the microstructure of deformed samples before and after annealing. The values of the S parameter present a decrease for all studied FeSi alloys with the increase of the annealing temperature, being attributed to a decrease of the concentration of defects. A sudden increase of the S-parameter value at 600?°C was observed for all samples, which could be related to the change of the ordering of the FeSi alloys at that temperature. At 700 °C, the values of the S parameter decreased drastically and starting from 900?°C, they became constant. The microstructures of the alloys, investigated by OM, show that recrystallization is completed at 900?°C and the samples are mainly free of defects, which is in agreement with the positron annihilation lifetime data.Materials Science and EngineeringMechanical, Maritime and Materials Engineerin
Author Correction: Safety and efficacy of anti-tau monoclonal antibody gosuranemab in progressive supranuclear palsy: a phase 2, randomized, placebo-controlled trial (Nature Medicine, (2021), 27, 8, (1451-1457), 10.1038/s41591-021-01455-x)
No full textCorrection to: Nature Medicine, published online 12 August 2021. In the version of this article initially published, members of the PASSPORT Study Group were listed in Supplementary information but not included in the main article. The contributors are listed below for inclusion in authorship. PASSPORT Study Group Ikuko Aiba1, Angelo Antonini2, Diana Apetauerova3, Jean-Philippe Azulay4, Ernest Balaguer Martinez5, Jee Bang6, Paolo Barone7, Matthew Barrett8, Danny Bega9, Daniela Berg10, Koldo Berganzo Corrales11, Yvette Bordelon12, Adam L. Boxer13, Moritz Brandt14, Norbert Brueggemann15, Giovanni Castelnovo16, Roberto Ceravolo17, Rosalind Chuang18, Sun Ju Chung19, Alistair Church20, Jean-Christophe Corvol21, Paola Cudia2, Marian Dale22, Luc Defebvre23, Sophie Drapier24, Erika D Driver-Dunckley25, Georg Ebersbach26, Karla M Eggert27, Aaron Ellenbogen28, Alexandre Eusebio4, Andrew H Evans29, Natalia Fedorova30, Elizabeth Finger31, Alexandra Foubert-Samier32, Boyd Ghosh33, Lawrence Golbe34, Francisco Grandas Perez35, Murray Grossman36, Deborah Hall37, Kyoko Hamada38, Kazuko Hasegawa39, Guenter Hoeglinger40, Lawrence Honig41, David Houghton42, Xuemei Huang43, Stuart Isaacson44, SeongBeom Koh45, Jaime Kulisevsky Bojarski46, Anthony E. Lang47, Peter Nigel Leigh48, Irene Litvan49, Juan Jose Lopez Lozano50, Jose Luis Lopez-Sendon Moreno51, Albert Christian Ludolph52, Ma Rosario Luquin Piudo53, Irene Martinez Torres54, Nikolaus McFarland55, Wassilios Meissner32, Tiago Mestre56, Pablo Mir Rivera57, Eric Molho58, Britt Mollenhauer59, Huw R Morris60, Miho Murata61, Tomokazu Obi62, Fabienne Ory Magne63, Padraig O’Suilleabhain64, Rajesh Pahwa65, Alexander Pantelyat6, Nicola Pavese66, Dmitry Pokhabov67, Johannes Prudlo68, Federico Rodriguez-Porcel22, James Rowe69, Joseph Savitt70, Alfons Schnitzler71, Joerg B Schulz72, Klaus Seppi73, Binit Shah8, Holly Shill74, David Shprecher75, Maria Stamelou76, Malcolm Steiger77, Yuji Takahashi61, Hiroshi Takigawa78, Carmela Tartaglia79, Lars Toenges80, Daniel Truong81, Winona Tse82, Paul Tuite83, Dieter Volc84, Anne-Marie A Wills85, Dirk Woitalla86, Tao Xie87, Tatsuhiko Yuasa88, Sarah Elizabeth Zauber89 and Theresa Zesiewicz901Department of Neurology, National Hospital Organization Higashinagoya National Hospital, Nagoya, Japan. 2San Camillo Hospital IRCCS, Venice Lido, Italy. 3Lahey Hospital and Medical Center, Burlington, MA, USA. 4Assistance Publique Hapitaux De Marseille, Marseille, France. 5Hospital General de Catalunya, Barcelona, Spain. 6The Johns Hopkins University, Baltimore, MD, USA. 7AOU San Giovanni di Dio e Ruggi d’Aragona University di Salerno, Salerno, Italy. 8University of Virginia Health System, Charlottesville, VA, USA. 9Northwestern University, Chicago, IL, USA. 10UKSH - Campus Kiel, Kiel, Germany. 11Hospital De Cruces, Barakaldo, Spain. 12University of California, Los Angeles, CA, USA. 13Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA. 14Universitatsklinikum Carl Gustav Carus Dresden, Dresden, Germany. 15University Hospital Schleswig-Holstein, Luebeck, Germany. 16Centre Hospitalier Universitaire de Nimes - Hopital Universitaire Caremeau, Nimes, France. 17University Hospital of Pisa, Pisa, Italy. 18Swedish Health Services, Seattle, WA, USA. 19Asan Medical Center, Seoul, Republic of Korea. 20Aneurin Bevan University Health BoardClinical Research and Innovation Centre - St Woolos Hospital, Newport, UK. 21Sorbonne Université, Assistance Publique Hôpitaux de Paris, INSERM, CNRS, Institut du Cerveau – Paris Brain Institute – ICM, Hôpital Pitié-Salpêtrière, Paris, France. 22Medical University of South Carolina, Charleston, SC, USA. 23Centre Hospitalier Regional Universitaire) de Lille - Hopital Roger Salengro, Lille, France. 24CHU de Rennes - Hopital de Pontchaillou, Rennes, France. 25Mayo Clinic Arizona - Scottsdale, Scottsdale, AZ, USA. 26Movement Disorders Clinic, Beelitz-Heilstatten, Germany. 27Philipps Universitat Marburg, Marburg, Germany. 28QUEST Research Institute, Farmington Hills, MI, USA. 29The Royal Melbourne Hospital (RMH)-Flemington Neurology - North Melbourne, North Melbourne, Australia. 30Russian Medical Academy of Postgraduate Education, Moscow, Russia. 31Parkwood Institute, London, Ontario, Canada. 32CHU De Bordeaux Parkinson Expert Centre, IMNC Hopital Pellegrin, Bordeaux, France. 33University Hospital Southampton NHS Foundation Trust, Southampton UK. 34 Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA. 35Hospital General Universitario Gregorio Maranon, Madrid, Spain. 36Hospital of the University of Pennsylvania, Philadelphia, PA, USA. 37Rush University Medical Centre Chicago, IL USA. 38Shinsapporo Neurosurgical Hospital, Sapporo, Japan. 39National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan. 40Department of Neurology, Technische Universität München, Munich, Germany. 41Columbia University College of Physicians and Surgeons - Gertrude H. Sergievsky Center, New York, NY, USA. 42Ochsner Medical Center, New Orleans, LA, USA. 43Penn State University-Milton S. Hershey Medical Center, Hershey, PA USA. 44Parkinson’s Disease And Movement Disorder Center Of Boca Raton, Boca Raton, FL, USA. 45Korea University Guro Hospital, Seoul, Republic of Korea. 46Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. 47 Edmond J. Safra Program in Parkinson’s Disease and the Rossy PSP Centre, Toronto Western Hospital and the University of Toronto, Toronto, Ontario, Canada. 48Brighton and Sussex Medical School Trafford Centre for Biomedical Research, Brighton, UK. 49University of California, Parkinson and Other Movement Disorders Center, San Diego, CA, USA. 50Clinica Ruber Internacional, Madrid, Spain. 51Hospital Universitario Ramon y Cajal, Madrid, Spain. 52Universitats- und Rehabilitationskliniken Ulm, Ulm, Germany. 53Clinica Universidad De Navarra, Pamplona, Spain. 54Hospital la FE, Valencia, Spain. 55University of Florida Center For Movement Disorders and Neurorestoration, Gainesville, FL, USA. 56The Ottawa Hospital - Civic Campus, University of Ottawa, Ottawa, Canada. 57Hospital Universitario Virgen del Rocio, Sevilla, Spain. 58Albany Medical College, Albany, NY, USA. 59Paracelsus-Elena-Klinik Kassel, Kassel, Germany. 60National Hospital for Neurology and Neurosurgery, London, UK. 61Musashi Hospital, Kodaira-Shi, Japan. 62National Hospital Organization - Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan. 63Hopital Purpan - Batiment Pierre Paul Riquet, Toulouse, France. 64University of Texas Southwestern Medical Center - Clinical Center For Movement Disorders, Dallas, TX, USA. 65The University of Kansas Medical Center - Parkinson’s Disease and Movement Disorder Center, Kansas City, KS, USA. 66The Newcastle upon Tyne Hospitals NHS Foundation Trust - Campus for Ageing and Vitality, Newcastle upon Tyne, UK. 67Federal State Budgetary Institution, Federal Siberian Scientific Clinical Center of Federal Medical-Biological Agency, Krasnoyarsk, Russia. 68Universitaet Rostock - Universitaetsmedizin Rostock, Rostock, Germany. 69Cambridge University, Cambridge, UK. 70University of Maryland School of Medicine, Baltimore, MD, USA. 71Center for Movement Disorders and Neuromodulation-University Hospital Dusseldorf, Dusseldorf, Germany. 72Uniklinik RWTH Aachen Medizinische Klinik III, Aachen, Germany. 73Medizinische Universitaet Innsbruck, Innsbruck, Austria. 74St. Joseph’s Hospital and Medical Center/Barrow Neurology Clinics, Phoenix, AZ, USA. 75Banner Sun Health Research Institute, Sun City, AZ, USA. 76Hygeia Hospital, Marousi, Greece. 77The Walton Center - NHS Foundation Trust, Liverpool, UK. 78Tottori University Hospital, Yonago, Japan. 79Toronto Western Hospital, University Health Network Movement Disorders Centre, Toronto, Canada. 80St. Josef - Hospital Bochum, Kardiologische Studienambulanz, Bochum, Germany. 81The Parkinson’s and Movement Disorder Institute, Fountain Valley, CA, USA. 82Mount Sinai Movement Disorders Center, New York,NY, USA. 83University of Minnesota Medical Center - Fairview - Neurology Clinic, Minneapolis, MN, USA. 84Prosenex Ambulatoriumsbetriebs GmbH – Studienzentrum, Vienna, Austria. 85Massachusetts General Hospital Cancer Center, Boston, MA, USA. 86St. JosefKrankenhaus, Essen-Kupferdreh, Essen, Germany. 87The University of Chicago Medicine - Center for Parkinson’s Disease and Movement Disorders, Chicago, IL, USA. 88Kamagaya General Hospital, Kamagaya-City, Japan. 89Indiana University Health Physicians - Neurology – Indianapolis, Indianapolis, IN, USA. 90University of South Florida - Morsani College of Medicine, Tampa, FL, USA
"Disney is the Tiffany’s and I am the Woolworth's of the business": A critical re-analysis of the business philosophies, production values and studio practices of animator-producer Paul Houlton Terry
No full textThis thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Animator-producer Paul Houlton Terry has been portrayed as having little passion for the animation he produced and being more concerned with making a profit than producing entertaining cartoons with high production values. The purpose of the dissertation is to re-evaluate Terry‘s legacy to animated cartooning by analyzing his business philosophies, production values, and studio practices.
Application of four psychodynamic factors to the early life and career of Terry, 1887-1929, found that his economic decision making was characterized by: an external locus of control, risk-averse financial behaviour, extreme saving behaviour through precaution, and shrewd money management practices. Based on Terry‘s historical responses to twelve major economic, technological, or institutional forces of change for the period 1929-1955, the psychodynamic factors were found to provide accurate explanations for his studio practices and production decisions.
There was no evidence to support the conclusion that three early career disappointments undermined Terry‘s intrinsic motivation to create animated cartoons. Rather, Terry‘s lack of risk taking, external locus of control, tight studio production schedule, desire to compete with neighbour studio Fleischer, difficulty in separating financial rewards from creative processes in animation, and practice of undertaking surveillance measures on staff may have undermined his and his studio‘s creativity. Archival research found Terry to possess strong passions for and to have made significant creative contributions to the field of animation.
Biographical research found that Terry retained a stable nucleus of highly talented artists who dedicated a significant portion of their working careers to the studio. An analysis of the cel aesthetics of a random sample of animated cartoons produced during the years 1930-1955 found that Terry created animated cartoons with above average cel aesthetics when compared to the other studios thereby supporting an inference that Terry was motivated to producing quality crafted animation. Further research is suggested into the role psychodynamic factors and economic decision-making play in the film production process and a clarification of Terry‘s legacy to the field of animated cartoons
Why Worry About Climate Change? A Research Agenda
No full textEstimates of the marginal damage costs of carbon dioxide emissions suggest that, although climate change is a problem and some emission reduction is justified, very stringent abatement does not pass the cost-benefit test. However, current estimates of the economic impact of climate change are incomplete. Some of the missing impacts are likely to be positive and others negative, but overall the uncertainty seems to concentrate on the downside risks and current estimates of the damage costs may have a negative bias. The research effort on the economic impacts of climate change is minute, and should be strengthened, with a particular focus on the quantification of uncertainties; estimating missing impacts, interactions between impacts and higher-order effects; the valuation of biodiversity loss; the implications of extreme climate scenarios and violent conflict; and climate change in the very long term.Climate Change, Impacts, Valuation, Cost-benefit Analysis
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury
No full textAcute tubular necrosis mediates acute kidney injury (AKI) and nephron loss1, the hallmark of end-stage renal disease2-4. For decades, it has been known that female kidneys are less sensitive to AKI5,6. Acute tubular necrosis involves dynamic cell death propagation by ferroptosis along the tubular compartment7,8. Here we demonstrate abrogated ferroptotic cell death propagation in female kidney tubules. 17β-oestradiol establishes an anti-ferroptotic state through non-genomic and genomic mechanisms. These include the potent direct inhibition of ferroptosis by hydroxyoestradiol derivatives, which function as radical trapping antioxidants, are present at high concentrations in kidney tubules and, when exogenously applied, protect male mice from AKI. In cells, the oxidized hydroxyoestradiols are recycled by FSP19,10, but FSP1-deficient female mice were not sensitive to AKI. At the genomic level, female ESR1-deficient kidney tubules partially lose their anti-ferroptotic capacity, similar to ovariectomized mice. While ESR1 promotes the anti-ferroptotic hydropersulfide system, male tubules express pro-ferroptotic proteins of the ether lipid pathway which are suppressed by ESR1 in female tissues until menopause. In summary, we identified non-genomic and genomic mechanisms that collectively explain ferroptosis resistance in female tubules and may function as therapeutic targets for male and postmenopausal female individuals.
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