1,721,071 research outputs found
Hydrogeological implications of the resistivity distribution inferred from electrical prospecting data from the Apulian carbonate platform
No full textInterpretation of shallow Schlumberger soundings in the western sector of Mt.Etna, Sicily
No full textInterpretation of shallow Schlumberger soundings in the western sector of Mt.Etna, Sicily
No full textInterpretation of shallow Schlumberger soundings in the western sector of Mt.Etna, Sicily
No full textSmall Extracellular Vesicles from Human Amniotic Fluid Samples as Promising Theranostics
No full textSince the first evidence that stem cells can provide pro-resolving effects via paracrine secretion of soluble factors, growing interest has been addressed to define the most ideal cell source for clinical translation. Leftover or clinical waste samples of human amniotic fluid obtained following prenatal screening, clinical intervention, or during scheduled caesarean section (C-section) delivery at term have been recently considered an appealing source of mesenchymal progenitors with peculiar regenerative capacity. Human amniotic fluid stem cells (hAFSC) have been demonstrated to support tissue recovery in several preclinical models of disease by exerting paracrine proliferative, anti-inflammatory and regenerative influence. Small extracellular vesicles (EVs) concentrated from the hAFSC secretome (the total soluble trophic factors secreted in the cell-conditioned medium, hAFSC-CM) recapitulate most of the beneficial cell effects. Independent studies in preclinical models of either adult disorders or severe diseases in newborns have suggested a regenerative role of hAFSC-EVs. EVs can be eventually concentrated from amniotic fluid (hAF) to offer useful prenatal information, as recently suggested. In this review, we focus on the most significant aspects of EVs obtained from either hAFSC and hAF and consider the current challenges for their clinical translation, including isolation, characterization and quantification methods
Integrated geophysical survey for the geological structural and hydrogeothermal study of the North-western Gargano promontory (Southern Italy)
No full textA multimethodological geophysical survey was performed in the north-western part of the Gargano promontory to study the geological structural setting and the underground fluid flow characteristics. The area has a complex tectonics with some magmatic outcrops and shallow low-enthalpy waters. Electrical, seismic reflection, gravimetric and magnetic surveys were carried out to reconstruct the geological structures; and in order to delineate the hydrogeothermal characteristics of the area, the self-potential survey was mainly used. Moreover magnetic and self-potential measurements were also performed in the Lesina lake. The joint three-dimensional interpretation of the geophysical data disclosed a large horst and graben structure covering a large part of the area. In the central part of the horst a large ramified volcanic body was modelled. The models show some intrusions rising from it to or near to the surface. The main structures are well deep-seated in the Crust and along them deep warm fluids rise as the SP data interpretation indicates
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