1,720,981 research outputs found
[Epithelial splenic cysts].
No full textThe authors describe a case of an epithelial cyst of the spleen treated successfully by splenectomy. Diagnostic techniques and the principles adopted in treatment this rare disease are discussed
Is the presence of laminin receptor an independent prognostic factor in breast cancer? Preliminary results.
No full text[Clinical and histopathological aspects of lobular capillary hemangioma (pyogenic granuloma) in the stomatognathic system].
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Tumor proliferative activity and response to first-line chemotherapy in advanced breast cancer.
No full textbcl-2 but not p53 expression is associated with resistance to chemotherapy in advanced breast cancer
No full textProgrammed cell death is an important determinant of the response to chemotherapy. Among the factors controlling this process, a significant role is played by bcl-2 and p53, the expression of which, together with estrogen receptor content and tumor proliferative activity, was investigated by means of immunohistochemistry in 55 advanced breast cancer patients (median age, 60 years ; range, 25-71 years). Analysis of bcl-2 expression identified two groups of patients with a significant difference in response rate. A total of 17 patients (31%) responded to chemotherapy (5 had a complete response and 12 had a partial response): 14 of 32 (44%) bcl-2-negative patients (=40% of stained cells; P = 0.019 by Fisher's exact test). The two groups were well balanced in terms of age, performance status, disease-free survival, menopausal status, and type of chemotherapy. bcl-2-negative tumors showed a tendency toward a higher p53 expression and proliferation rate, whereas an excess of bone as the dominant disease site was evident among the bcl-2-positive ones. However, the only variable to result significantly different between the two groups was estrogen receptor expression (P = 0.004). A multivariate logistic regression model showed that bcl-2 maintained its power of discriminating two groups with a different probability of responding to chemotherapy, although the greatest contribution was given by dominant disease site and type of chemotherapy. In conclusion, the results of this study suggest a possible role for bcl-2 in predicting resistance to chemotherapy
Prognostic significance of laminin, laminin receptor and bone marrow micrometastases in breast cancer patinets. Are these markers of aggressive behavior and metastatic potential?
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